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ZNF263 zinc finger protein 263 [ Homo sapiens (human) ]

Gene ID: 10127, updated on 4-Nov-2022

Summary

Official Symbol
ZNF263provided by HGNC
Official Full Name
zinc finger protein 263provided by HGNC
Primary source
HGNC:HGNC:13056
See related
Ensembl:ENSG00000006194 MIM:604191; AllianceGenome:HGNC:13056
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPM315; ZSCAN44; ZKSCAN12
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF263 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (3283491..3301401)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (3310540..3318509)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3333491..3341460)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MEFV innate immunity regulator, pyrin Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene tigger transposable element derived 7 Neighboring gene zinc finger protein 75a Neighboring gene ribosomal protein L7 like 1 pseudogene Neighboring gene olfactory receptor family 2 subfamily C member 1 Neighboring gene uncharacterized LOC105371059 Neighboring gene MT-CO2 pseudogene 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
zinc finger protein 263
Names
zinc finger protein FPM315
zinc finger protein with KRAB and SCAN domains 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411015.1NP_001397944.1  zinc finger protein 263 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC004232
    Consensus CDS
    CCDS92094.1
    UniProtKB/TrEMBL
    D3DUC1
  2. NM_005741.5NP_005732.2  zinc finger protein 263 isoform 1

    See identical proteins and their annotated locations for NP_005732.2

    Status: VALIDATED

    Source sequence(s)
    AK312421, BC008805
    Consensus CDS
    CCDS10499.1
    UniProtKB/Swiss-Prot
    O14978, Q96H95
    Related
    ENSP00000219069.5, ENST00000219069.6
    Conserved Domains (6) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:218277
    KRAB; krueppel associated box
    COG5048
    Location:434649
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:380400
    zf-C2H2; Zinc finger, C2H2 type
    pfam15498
    Location:128347
    Dendrin; Nephrin and CD2AP-binding protein, Dendrin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    3283491..3301401
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522344.3XP_011520646.1  zinc finger protein 263 isoform X1

    UniProtKB/TrEMBL
    D3DUC1
    Related
    ENSP00000461755.2, ENST00000574674.2
    Conserved Domains (8) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:218277
    KRAB; krueppel associated box
    COG5048
    Location:434649
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:218256
    KRAB; KRAB box
    pfam02023
    Location:38125
    SCAN; SCAN domain
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    3310540..3318509
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)