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ZNF263 zinc finger protein 263 [ Homo sapiens (human) ]

Gene ID: 10127, updated on 10-Oct-2019

Summary

Official Symbol
ZNF263provided by HGNC
Official Full Name
zinc finger protein 263provided by HGNC
Primary source
HGNC:HGNC:13056
See related
Ensembl:ENSG00000006194 MIM:604191
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FPM315; ZSCAN44; ZKSCAN12
Expression
Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF263 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (3283183..3301649)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (3333380..3351401)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene MEFV innate immuity regulator, pyrin Neighboring gene long intergenic non-protein coding RNA 921 Neighboring gene tigger transposable element derived 7 Neighboring gene zinc finger protein 75a Neighboring gene ribosomal protein L7 like 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IC
Inferred by Curator
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of transcription, DNA-templated TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 263
Names
zinc finger protein FPM315
zinc finger protein with KRAB and SCAN domains 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005741.5NP_005732.2  zinc finger protein 263

    See identical proteins and their annotated locations for NP_005732.2

    Status: VALIDATED

    Source sequence(s)
    AK312421, BC008805
    Consensus CDS
    CCDS10499.1
    UniProtKB/Swiss-Prot
    O14978
    Related
    ENSP00000219069.5, ENST00000219069.6
    Conserved Domains (6) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:218277
    KRAB; krueppel associated box
    COG5048
    Location:434649
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:380400
    zf-C2H2; Zinc finger, C2H2 type
    pfam15498
    Location:128347
    Dendrin; Nephrin and CD2AP-binding protein, Dendrin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20190905

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    3283183..3301649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017022850.2XP_016878339.1  zinc finger protein 263 isoform X6

  2. XM_011522344.2XP_011520646.1  zinc finger protein 263 isoform X1

    See identical proteins and their annotated locations for XP_011520646.1

    UniProtKB/TrEMBL
    D3DUC1
    Conserved Domains (8) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:218277
    KRAB; krueppel associated box
    COG5048
    Location:434649
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:218256
    KRAB; KRAB box
    pfam02023
    Location:38125
    SCAN; SCAN domain
    pfam13465
    Location:504529
    zf-H2C2_2; Zinc-finger double domain
  3. XM_006720832.2XP_006720895.1  zinc finger protein 263 isoform X3

    Conserved Domains (8) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:218292
    KRAB; krueppel associated box
    COG5048
    Location:395610
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:397417
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:395417
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:218256
    KRAB; KRAB box
    pfam02023
    Location:38125
    SCAN; SCAN domain
    pfam13465
    Location:465490
    zf-H2C2_2; Zinc-finger double domain
  4. XM_006720831.2XP_006720894.1  zinc finger protein 263 isoform X2

    Conserved Domains (8) summary
    smart00431
    Location:38149
    SCAN; leucine rich region
    smart00349
    Location:205264
    KRAB; krueppel associated box
    COG5048
    Location:421636
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:423443
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:421443
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:205243
    KRAB; KRAB box
    pfam02023
    Location:38125
    SCAN; SCAN domain
    pfam13465
    Location:491516
    zf-H2C2_2; Zinc-finger double domain
  5. XM_006720833.2XP_006720896.1  zinc finger protein 263 isoform X4

    Conserved Domains (8) summary
    smart00431
    Location:38131
    SCAN; leucine rich region
    smart00349
    Location:133192
    KRAB; krueppel associated box
    COG5048
    Location:349564
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:351371
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:349371
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:133171
    KRAB; KRAB box
    pfam02023
    Location:38125
    SCAN; SCAN domain
    pfam13465
    Location:419444
    zf-H2C2_2; Zinc-finger double domain
  6. XM_006720834.4XP_006720897.1  zinc finger protein 263 isoform X5

    See identical proteins and their annotated locations for XP_006720897.1

    Conserved Domains (6) summary
    cd07765
    Location:1352
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:1473
    KRAB; krueppel associated box
    COG5048
    Location:256445
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:232252
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:230252
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:300325
    zf-H2C2_2; Zinc-finger double domain
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