ZNF263 zinc finger protein 263 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZNF263provided by HGNC
Official Full Name: zinc finger protein 263provided by HGNC
Primary source: HGNC:HGNC:13056
See related: Ensembl:ENSG00000006194 MIM:604191; AllianceGenome:HGNC:13056
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: FPM315; ZSCAN44; ZKSCAN12
Summary: Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and transcription cis-regulatory region binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary (RPKM 7.9), testis (RPKM 7.1) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (3283491..3301401)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (3290853..3328457)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (3333491..3351401)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance.
Title: Zinc finger protein 263 promotes colorectal cancer cell progression by activating STAT3 and enhancing chemoradiotherapy resistance.
Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer.
Title: Zinc finger protein 263 upregulates interleukin 33 and suppresses autophagy to accelerate the malignant progression of non-small cell lung cancer.
Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.
Title: Transcription factor ZNF263 enhances EGFR-targeted therapeutic response and reduces residual disease in lung adenocarcinoma.
Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
Title: Chromatin-associated OGT promotes the malignant progression of hepatocellular carcinoma by activating ZNF263.
Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.
Title: Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
Title: The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
Title: ZNF263 is a transcriptional regulator of heparin and heparan sulfate biosynthesis.
Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263.
Title: Genomic targets of the KRAB and SCAN domain-containing zinc finger protein 263.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ZNF263_9047 (e-PCR)
- UniSTS:468815

D16S2676 (e-PCR)
- UniSTS:152425

G19656 (e-PCR)
- UniSTS:39552

A001U12 (e-PCR)
- UniSTS:39553

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables transcription cis-regulatory region binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 263

Names: zinc finger protein FPM315; zinc finger protein with KRAB and SCAN domains 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411015.1 → NP_001397944.1 zinc finger protein 263 isoform 2

Status: VALIDATED

Source sequence(s)

AC004232

Consensus CDS

CCDS92094.1

UniProtKB/TrEMBL

D3DUC1, I3L4C4, I3L538

Related

ENSP00000461755.2, ENST00000574674.2
NM_005741.5 → NP_005732.2 zinc finger protein 263 isoform 1

See identical proteins and their annotated locations for NP_005732.2

Status: VALIDATED

Source sequence(s)

AK312421, BC008805

Consensus CDS

CCDS10499.1

UniProtKB/Swiss-Prot

B2R634, O14978, O43387, Q96H95

Related

ENSP00000219069.5, ENST00000219069.6

Conserved Domains (6) summary

smart00431
Location:38 → 149

SCAN; leucine rich region

smart00349
Location:218 → 277

KRAB; krueppel associated box

COG5048
Location:434 → 649

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:436 → 456

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:380 → 400

zf-C2H2; Zinc finger, C2H2 type

pfam15498
Location:128 → 347

Dendrin; Nephrin and CD2AP-binding protein, Dendrin