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CGAS cyclic GMP-AMP synthase [ Loxodonta africana (African savanna elephant) ]

Gene ID: 100664322, updated on 11-Apr-2024

Summary

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Gene symbol
CGAS
Gene description
cyclic GMP-AMP synthase
See related
EnsemblRapid:ENSLAFG00000010167
Gene type
protein coding
RefSeq status
MODEL
Organism
Loxodonta africana
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Afrotheria; Proboscidea; Elephantidae; Loxodonta
Also known as
MB21D1
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_04 current mLoxAfr1.hap2 (GCF_030014295.1) 1 NC_087342.1 (134928228..134969488, complement)
102 previous assembly Loxafr3.0 (GCF_000001905.1) Unplaced Scaffold NW_003573420.1 (92456439..92478497)

Chromosome 1 - NC_087342.1Genomic Context describing neighboring genes Neighboring gene oocyte-expressed protein homolog Neighboring gene DEAD-box helicase 43 Neighboring gene mitochondrial tRNA translation optimization 1 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 Neighboring gene solute carrier family 17 member 5 Neighboring gene CD109 molecule

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cellular response to exogenous dsRNA IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in paracrine signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of defense response to virus by host IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of type I interferon production IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in site of double-strand break IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cyclic GMP-AMP synthase
Names
Mab-21 domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030014295.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mLoxAfr1.hap2

Genomic

  1. NC_087342.1 Reference mLoxAfr1.hap2

    Range
    134928228..134969488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_064288014.1 → XP_064144084.1  cyclic GMP-AMP synthase isoform X2

  2. XM_003404110.4 → XP_003404158.1  cyclic GMP-AMP synthase isoform X1

    UniProtKB/TrEMBL
    G3T540
    Related
    ENSLAFP00000036464.1, ENSLAFT00000053504.1
    Conserved Domains (2) summary
    pfam03281
    Location:212 → 510
    Mab-21; Mab-21 protein
    pfam15761
    Location:2 → 79
    IMUP; Immortalization up-regulated protein
Nucleotide Protein
Heading Accession and Version

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