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SCAMP2 secretory carrier membrane protein 2 [ Homo sapiens (human) ]

Gene ID: 10066, updated on 17-Jun-2019

Summary

Official Symbol
SCAMP2provided by HGNC
Official Full Name
secretory carrier membrane protein 2provided by HGNC
Primary source
HGNC:HGNC:10564
See related
Ensembl:ENSG00000140497 MIM:606912
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene product belongs to the SCAMP family of proteins which are secretory carrier membrane proteins. They function as carriers to the cell surface in post-golgi recycling pathways. Different family members are highly related products of distinct genes, and are usually expressed together. These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Expression
Ubiquitous expression in colon (RPKM 41.0), small intestine (RPKM 37.7) and 25 other tissues See more
Orthologs

Genomic context

See SCAMP2 in Genome Data Viewer
Location:
15q24.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (74843730..74873365, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (75137197..75165670, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370897 Neighboring gene complexin 3 Neighboring gene microRNA 6882 Neighboring gene unc-51 like kinase 3 Neighboring gene mannose phosphate isomerase Neighboring gene family with sequence similarity 219 member B Neighboring gene cytochrome c oxidase subunit 5A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
NHGRI GWA Catalog

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
post-Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
PubMed 
protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
recycling endosome membrane IDA
Inferred from Direct Assay
more info
PubMed 
trans-Golgi network membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 
transport vesicle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
secretory carrier-associated membrane protein 2
Names
testis secretory sperm-binding protein Li 219p

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320778.2NP_001307707.1  secretory carrier-associated membrane protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC091230, AK291884, CD300387, R59393
    UniProtKB/TrEMBL
    A8K769
    Conserved Domains (1) summary
    pfam04144
    Location:160336
    SCAMP; SCAMP family
  2. NM_005697.5NP_005688.2  secretory carrier-associated membrane protein 2 isoform 2

    See identical proteins and their annotated locations for NP_005688.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a exon in the central coding region compared to variant 1. The encoded isoform (2) is sorter than isoform 2.
    Source sequence(s)
    AC091230, BC004385, R59393
    Consensus CDS
    CCDS10271.1
    UniProtKB/Swiss-Prot
    O15127
    UniProtKB/TrEMBL
    A0A140VK92
    Related
    ENSP00000268099.9, ENST00000268099.13
    Conserved Domains (1) summary
    pfam04144
    Location:117293
    SCAMP; SCAMP family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    74843730..74873365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021856.1XP_016877345.1  secretory carrier-associated membrane protein 2 isoform X1

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