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ST20-MTHFS ST20-MTHFS readthrough [ Homo sapiens (human) ]

Gene ID: 100528021, updated on 10-Dec-2024

Summary

Official Symbol
ST20-MTHFSprovided by HGNC
Official Full Name
ST20-MTHFS readthroughprovided by HGNC
Primary source
HGNC:HGNC:44655
See related
Ensembl:ENSG00000259332 AllianceGenome:HGNC:44655
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MTHFS
Summary
This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010]
Expression
Broad expression in liver (RPKM 20.4), kidney (RPKM 11.5) and 23 other tissues See more
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Genomic context

See ST20-MTHFS in Genome Data Viewer
Location:
15q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (79843547..79923092, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (77706557..77786041, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (80135889..80215434, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 667, pseudogene Neighboring gene uncharacterized LOC124903536 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80146049-80146550 Neighboring gene methenyltetrahydrofolate synthetase Neighboring gene Sharpr-MPRA regulatory region 2833 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6724 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9934 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6725 Neighboring gene suppressor of tumorigenicity 20 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9936 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:80216673-80217333 Neighboring gene ST20 antisense RNA 1 Neighboring gene farnesyl diphosphate synthase pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9937 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr15:80262962-80264161 Neighboring gene BCL2 related protein A1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General protein information

Preferred Names
ST20-MTHFS protein
Names
5,10-methenyl-tetrahydrofolate synthetase
5-formyltetrahydrofolate cyclo-ligase
Methenyl-THF synthetase
NP_001186689.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001199760.2NP_001186689.1  ST20-MTHFS protein

    Status: VALIDATED

    Source sequence(s)
    AC021483, CK002935
    UniProtKB/TrEMBL
    A0A0A6YYL1, Q96EE9
    Related
    ENSP00000489525.1, ENST00000615374.5
    Conserved Domains (1) summary
    pfam01812
    Location:2174
    5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    79843547..79923092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    77706557..77786041 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)