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PCBP1 poly(rC) binding protein 1 [ Sus scrofa (pig) ]

Gene ID: 100511501, updated on 8-Mar-2024

Summary

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Gene symbol
PCBP1
Gene description
poly(rC) binding protein 1
Gene type
protein coding
RefSeq status
MODEL
Organism
Sus scrofa
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 3
Exon count:
1
Annotation release Status Assembly Chr Location
106 current Sscrofa11.1 (GCF_000003025.6) 3 NC_010445.4 (72378643..72380364, complement)
105 previous assembly Sscrofa10.2 (GCF_000003025.5) 3 NC_010445.3 (75813906..75815624, complement)

Chromosome 3 - NC_010445.4Genomic Context describing neighboring genes Neighboring gene TIA1 cytotoxic granule associated RNA binding protein Neighboring gene chromosome 3 C2orf42 homolog Neighboring gene aspartic peptidase retroviral like 1 Neighboring gene MAX dimerization protein 1 Neighboring gene small nuclear ribonucleoprotein U4/U6.U5 subunit 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Poly(C)-binding protein 1, a novel N(pro)-interacting protein involved in classical swine fever virus growth. Li D, et al. J Virol, 2013 Feb. PMID 23221550, Free PMC Article
  2. Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication. Beura LK, et al. J Virol, 2011 Dec. PMID 21976648, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Using a yeast two-hybrid screen, authors identified poly(C)-binding protein 1 (PCBP1) as a novel interacting partner of the classical swine fever virus N(pro) protein.
    Title: Poly(C)-binding protein 1, a novel N(pro)-interacting protein involved in classical swine fever virus growth.
  2. Overall, the results presented here point toward an important role for PCBP1 and PCBP2 in regulating porcine reproductive and respiratory syndrome virus RNA synthesis via binding to viral nonstructural protein 1beta.
    Title: Cellular poly(c) binding proteins 1 and 2 interact with porcine reproductive and respiratory syndrome virus nonstructural protein 1β and support viral replication.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables mRNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
poly(rC)-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

  1. NC_010445.4 Reference Sscrofa11.1 Primary Assembly

    Range
    72378643..72380364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003125057.4 → XP_003125105.1  poly(rC)-binding protein 1

    UniProtKB/TrEMBL
    A0A4X1W9X7, A0A8D1RAQ4, A0A8W4FAT6
    Conserved Domains (2) summary
    cd00105
    Location:281 → 343
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd02396
    Location:99 → 163
    PCBP_like_KH; K homology RNA-binding domain, PCBP_like. Members of this group possess KH domains in a tandem arrangement. Most members, similar to the poly(C) binding proteins (PCBPs) and Nova, containing three KH domains, with the first and second domains, which are ...
Nucleotide Protein
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