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SIRT1 sirtuin 1 [ Pongo abelii (Sumatran orangutan) ]

Gene ID: 100443901, updated on 6-Jun-2024

Summary

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Gene symbol
SIRT1
Gene description
sirtuin 1
Locus tag
CR201_G0008434
See related
Ensembl:ENSPPYG00000002401
Gene type
protein coding
RefSeq status
MODEL
Organism
Pongo abelii
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 8
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 8 NC_071993.2 (76334617..76401004, complement)
RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 10 NC_071995.1 (72488504..72554881, complement)

Chromosome 8 - NC_071993.2Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene POU domain, class 5, transcription factor 1-like Neighboring gene large ribosomal subunit protein uL11-like Neighboring gene mitochondrial import inner membrane translocase subunit TIM14-like Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables NAD-dependent histone deacetylase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables p53 binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of rDNA heterochromatin IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
NAD-dependent protein deacetylase sirtuin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

  1. NC_071993.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Range
    76334617..76401004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054523398.2 → XP_054379373.1  NAD-dependent protein deacetylase sirtuin-1 isoform X2

    UniProtKB/TrEMBL
    A0A2J8WR64, A0A8I5U8I9

  2. XM_002820895.5 → XP_002820941.4  NAD-dependent protein deacetylase sirtuin-1 isoform X1

    UniProtKB/TrEMBL
    A0A2J8WR65, H2NAR9

  3. XM_024254165.3 → XP_024109933.2  NAD-dependent protein deacetylase sirtuin-1 isoform X3

    UniProtKB/TrEMBL
    A0A2J8WR62, A0A8I5U1P4
Nucleotide Protein
Heading Accession and Version

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