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SIRT1 sirtuin 1 [ Homo sapiens (human) ]

Gene ID: 23411, updated on 15-Dec-2018

Summary

Official Symbol
SIRT1provided by HGNC
Official Full Name
sirtuin 1provided by HGNC
Primary source
HGNC:HGNC:14929
See related
Ensembl:ENSG00000096717 MIM:604479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SIR2; SIR2L1; SIR2alpha
Summary
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]
Expression
Ubiquitous expression in adrenal (RPKM 17.4), testis (RPKM 16.6) and 25 other tissues See more
Orthologs

Genomic context

See SIRT1 in Genome Data Viewer
Location:
10q21.3
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (67884669..67918390)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (69644427..69678147)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 523, pseudogene Neighboring gene SIRT1 promoter region Neighboring gene ribosomal protein L12 pseudogene 8 Neighboring gene HECT and RLD domain containing E3 ubiquitin protein ligase 4 Neighboring gene ribosomal protein S3a pseudogene 38 Neighboring gene RNA, 7SL, cytoplasmic 220, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of SIRT1 by shRNA enhances HIV-1 transactivation in HIV latency condition, suggesting the direct involvement of SIRT1 to HIV latency PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of SIRT1 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed
tat HIV-1 Tat-induced inhibition of SIRT1 activity in TZM-bl cells is reversed by tanshinone II A (a main lipid-soluble monomer derivative from the root of Salvia miltiorrhiza) PubMed
tat HIV-1 Tat modulates SIRT1 expression in neuron cells PubMed
tat HIV-1 Tat upregulates miR-182 in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity by MiR-182 PubMed
tat HIV-1 Tat inhibits SIRT1 and increases acetylation of p53, which leads to activation of p21 and BAX in HeLa-CD4+ cells PubMed
tat HIV-1 Tat upregulates miR-34a in TZM-bl cells, which results in downregulation of SIRT1 protein expression and activity and induction of NFkappaB p65 acetylation by MiR-34a PubMed
tat HIV-1 Tat-induced expression of miR-217 downregulates SIRT1 and promotes HIV-1 LTR transactivation in MAGI cells PubMed
tat HIV-1 Tat is identified to have a physical interaction with sirtuin 1 (SIRT1) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
tat Tat causes NAD(+) depletion and inhibits Nicotinamide phosphoribosyltransferase (Nampt) mRNA and protein expression in cells. Nampt is critical in the regulation of Tat-induced inhibition of sirtuin 1 (SIRT1) activity and LTR transactivation PubMed
tat HIV-1 Tat binds the deacetylase domain (amino acids 341-512) of SIRT1 and inhibits SIRT1 deacetylase activity, which results in the induction of NF-kappaB hyperacetylation PubMed
tat Overexpression of SIRT1 attenuates Tat-induced HIV-1 transcription in MAGI cells PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat Deacetylation of HIV-1 Tat by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase, regulates Tat transactivation of the HIV-1 promoter PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Amphetamine addiction, organism-specific biosystem (from KEGG)
    Amphetamine addiction, organism-specific biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Amphetamine addiction, conserved biosystem (from KEGG)
    Amphetamine addiction, conserved biosystemAmphetamine is a psychostimulant drug that exerts persistent addictive effects. Most addictive drugs increase extracellular concentrations of dopamine (DA) in nucleus accumbens (NAc) and medial prefr...
  • Androgen receptor signaling pathway, organism-specific biosystem (from WikiPathways)
    Androgen receptor signaling pathway, organism-specific biosystemAndrogens, mainly testosterone and 5alpha-dihydrotestosterone (DHT) play significant role in the growth and development of the male reproductive organs. These steroid hormones bring about their biolo...
  • Cellular response to heat stress, organism-specific biosystem (from REACTOME)
    Cellular response to heat stress, organism-specific biosystemIn response to exposure to elevated temperature and certain other proteotoxic stimuli (e.g., hypoxia, free radicals) cells activate a number of cytoprotective mechanisms known collectively as "heat s...
  • Cellular responses to stress, organism-specific biosystem (from REACTOME)
    Cellular responses to stress, organism-specific biosystemCells are subject to external molecular and physical stresses such as foreign molecules that perturb metabolic or signaling processes, and changes in temperature or pH. The ability of cells and tissu...
  • Circadian Clock, organism-specific biosystem (from REACTOME)
    Circadian Clock, organism-specific biosystemAt the center of the mammalian circadian clock is a negative transcription/translation-based feedback loop: The BMAL1:CLOCK/NPAS2 (ARNTL:CLOCK/NPAS2) heterodimer transactivates CRY and PER genes by b...
  • Circadian rythm related genes, organism-specific biosystem (from WikiPathways)
    Circadian rythm related genes, organism-specific biosystemThis is currently not a pathway but a list of circadian rhythm related genes and proteins. The source for this information is the gene ontology. The genes and proteins were filtered for "circadian rh...
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • Epigenetic regulation of gene expression, organism-specific biosystem (from REACTOME)
    Epigenetic regulation of gene expression, organism-specific biosystemEpigenetic processes regulate gene expression by modulating the frequency, rate, or extent of gene expression in a mitotically or meiotically heritable way that does not entail a change in the DNA se...
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Glucagon signaling pathway, organism-specific biosystem (from KEGG)
    Glucagon signaling pathway, organism-specific biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • Glucagon signaling pathway, conserved biosystem (from KEGG)
    Glucagon signaling pathway, conserved biosystemGlucagon is conventionally regarded as a counterregulatory hormone for insulin and plays a critical anti-hypoglycemic role by maintaining glucose homeostasis in both animals and humans. To increase ...
  • HIF-2-alpha transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    HIF-2-alpha transcription factor network, organism-specific biosystem
    HIF-2-alpha transcription factor network
  • Integrated Breast Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Breast Cancer Pathway, organism-specific biosystemThis pathway incorporates the most important proteins for Breast Cancer. The Rp score from the Connectivity-Maps (C-Maps) webserver was used to determine the rank of the most important proteins in Br...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Longevity regulating pathway, organism-specific biosystem (from KEGG)
    Longevity regulating pathway, organism-specific biosystemRegulation of longevity depends on genetic and environmental factors. Caloric restriction (CR), that is limiting food intake, is recognized in mammals as the best characterized and most reproducible ...
  • Longevity regulating pathway - multiple species, organism-specific biosystem (from KEGG)
    Longevity regulating pathway - multiple species, organism-specific biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Longevity regulating pathway - multiple species, conserved biosystem (from KEGG)
    Longevity regulating pathway - multiple species, conserved biosystemAging is a complex process of accumulation of molecular, cellular, and organ damage, leading to loss of function and increased vulnerability to disease and death. Despite the complexity of aging, rec...
  • Melatonin metabolism and effects, organism-specific biosystem (from WikiPathways)
    Melatonin metabolism and effects, organism-specific biosystemMelatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptop...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • NAD metabolism, sirtuins and aging, organism-specific biosystem (from WikiPathways)
    NAD metabolism, sirtuins and aging, organism-specific biosystemA model for DNA damage, inflammation, NAD+, and aging. Two key events, the activation of PARP by DNA damage and the decreased NAMPT expression associated with inflammation, lead to decreased SIRT1 an...
  • NAD+ biosynthetic pathways, organism-specific biosystem (from WikiPathways)
    NAD+ biosynthetic pathways, organism-specific biosystemNAD+ biosynthetic pathways. NAD+ levels are maintained by three independent pathways. First, the Preiss-Handler pathway uses dietary nicotinic acid and the enzyme nicotinic acid phosphoribosyltransfe...
  • NAD+ metabolism, organism-specific biosystem (from WikiPathways)
    NAD+ metabolism, organism-specific biosystemNAD+ metabolism in different cellular compartments. The different precursors to intracellular NAD metabolism - tryptophan, nicotinic acid (NA), nicotinamide, NR, and NMN - are shown, along with their...
  • Negative epigenetic regulation of rRNA expression, organism-specific biosystem (from REACTOME)
    Negative epigenetic regulation of rRNA expression, organism-specific biosystemTranscription of rRNA genes is controlled by epigenetic activation and repression (reviewed in McStay and Grummt 2008, Goodfellow and Zomerdijk 2012, Grummt and Langst 2013). About half of the roughl...
  • RORA activates gene expression, organism-specific biosystem (from REACTOME)
    RORA activates gene expression, organism-specific biosystemAs inferred from mouse, RORA binds ROR elements (ROREs) in DNA and recruits the coactivators PPARGC1A (PGC-1alpha) and p300 (EP300, a histone acetylase) to activate transcription.
  • Regulation of Androgen receptor activity, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of Androgen receptor activity, organism-specific biosystem
    Regulation of Androgen receptor activity
  • Regulation of HSF1-mediated heat shock response, organism-specific biosystem (from REACTOME)
    Regulation of HSF1-mediated heat shock response, organism-specific biosystemThe ability of HSF1 to respond to cellular stresses is under negative regulation by chaperones, modulation of nucleocytoplasmic shuttling, post-translational modifications and transition from monomer...
  • Regulation of retinoblastoma protein, organism-specific biosystem (from Pathway Interaction Database)
    Regulation of retinoblastoma protein, organism-specific biosystem
    Regulation of retinoblastoma protein
  • SIRT1 negatively regulates rRNA Expression, organism-specific biosystem (from REACTOME)
    SIRT1 negatively regulates rRNA Expression, organism-specific biosystemExpression of rRNA genes is coupled to the overall metabolism of the cell by the NAD-dependent histone deacetylase SIRT1, a component of the Energy-dependent Nucleolar Silencing Complex (eNoSC) (Mura...
  • SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystem (from WikiPathways)
    SREBF and miR33 in cholesterol and lipid homeostasis, organism-specific biosystemThis pathway describes transcription factor-microRNA circuits governing cholesterol and lipid homeostasis. It is based on a seminar by Dr. Anders Näär.
  • Signaling events mediated by HDAC Class I, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class I, organism-specific biosystem
    Signaling events mediated by HDAC Class I
  • Signaling events mediated by HDAC Class III, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by HDAC Class III, organism-specific biosystem
    Signaling events mediated by HDAC Class III
  • Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystem (from WikiPathways)
    Simplified Interaction Map Between LOXL4 and Oxidative Stress Pathway, organism-specific biosystemThis pathway Involved in chemo-resistance of cells in bladder cancer begins with LOXL2 activation of CDC37 and COL2A1. COL2A1 activates the complex NRF1/2 and two other complexes that trigger RTK/MAP...
  • Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystem (from WikiPathways)
    Sterol Regulatory Element-Binding Proteins (SREBP) signalling, organism-specific biosystemSterol regulatory element-binding proteins (SREBPs) are membrane-bound proteins that act as transcription factors. They regulate lipid, especially cholesterol, biosynthesis and uptake at a transcript...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
HLH domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
PubMed 
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) ISS
Inferred from Sequence or Structural Similarity
more info
 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
NAD-dependent protein deacetylase activity TAS
Traceable Author Statement
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
bHLH transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bHLH transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase activity EXP
Inferred from Experiment
more info
PubMed 
histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
keratin filament binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA synthesis involved in DNA repair ISS
Inferred from Sequence or Structural Similarity
more info
 
UV-damage excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
behavioral response to starvation IEA
Inferred from Electronic Annotation
more info
 
cell aging TAS
Traceable Author Statement
more info
PubMed 
cellular glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to hypoxia IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to ionizing radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to leukemia inhibitory factor IEA
Inferred from Electronic Annotation
more info
 
cellular response to starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to tumor necrosis factor IDA
Inferred from Direct Assay
more info
PubMed 
cellular triglyceride homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
cholesterol homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
chromatin organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
chromatin silencing at rDNA IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing at rDNA TAS
Traceable Author Statement
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
establishment of chromatin silencing IDA
Inferred from Direct Assay
more info
PubMed 
fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
histone H3 deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone H3 deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3-K9 deacetylation IEA
Inferred from Electronic Annotation
more info
 
histone H3-K9 modification IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
leptin-mediated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage cytokine production ISS
Inferred from Sequence or Structural Similarity
more info
 
macrophage differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
maintenance of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
methylation-dependent chromatin silencing TAS
Traceable Author Statement
more info
PubMed 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of I-kappaB kinase/NF-kappaB signaling IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of androgen receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular response to testosterone stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cellular senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of helicase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of histone H3-K14 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H3-K9 trimethylation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of histone H4-K16 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
negative regulation of neuron death IEA
Inferred from Electronic Annotation
more info
 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-lysine acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of prostaglandin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of protein acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transforming growth factor beta receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
ovulation from ovarian follicle IEA
Inferred from Electronic Annotation
more info
 
peptidyl-lysine acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of MHC class II biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of adaptive immune response IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of adipose tissue development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of angiogenesis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of blood vessel endothelial cell migration IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cellular senescence IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cholesterol efflux ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endothelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of histone H3-K9 methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macrophage apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of smooth muscle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
proteasome-mediated ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT protein ADP-ribosylation TAS
Traceable Author Statement
more info
PubMed 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation TAS
Traceable Author Statement
more info
PubMed 
protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyrimidine dimer repair by nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of bile acid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of brown fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
regulation of endodeoxyribonuclease activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of lipid storage ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
regulation of peroxisome proliferator activated receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein import into nucleus, translocation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein serine/threonine kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of smooth muscle cell apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hydrogen peroxide IDA
Inferred from Direct Assay
more info
PubMed 
response to insulin ISS
Inferred from Sequence or Structural Similarity
more info
 
response to leptin ISS
Inferred from Sequence or Structural Similarity
more info
 
response to oxidative stress IDA
Inferred from Direct Assay
more info
PubMed 
single strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
stress-induced premature senescence IMP
Inferred from Mutant Phenotype
more info
PubMed 
transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
triglyceride mobilization ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
white fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex IDA
Inferred from Direct Assay
more info
PubMed 
PML body IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
NOT cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nuclear chromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rDNA heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-1
Names
SIR2-like protein 1
regulatory protein SIR2 homolog 1
sirtuin type 1
NP_001135970.1
NP_001300978.1
NP_036370.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_050664.1 RefSeqGene

    Range
    5008..38729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142498.1NP_001135970.1  NAD-dependent protein deacetylase sirtuin-1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AA452304, AK289743, BC012499, DB162635
    Consensus CDS
    CCDS44412.1
    UniProtKB/Swiss-Prot
    Q96EB6
    UniProtKB/TrEMBL
    A8K128, E9PC49
    Related
    ENSP00000409208.1, ENST00000432464.5
    Conserved Domains (1) summary
    cl00195
    Location:1194
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  2. NM_001314049.1NP_001300978.1  NAD-dependent protein deacetylase sirtuin-1 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and uses an alternate translation start site compared to variant 1. The encoded isoform (c) is shorter and has a distinct N-terminus compared to isoform a.
    Source sequence(s)
    AF235040, AK074805, BC012499, DB162635
    Consensus CDS
    CCDS81469.1
    UniProtKB/Swiss-Prot
    Q96EB6
    UniProtKB/TrEMBL
    B0QZ35
    Related
    ENSP00000384508.1, ENST00000406900.5
    Conserved Domains (1) summary
    cl00195
    Location:12186
    SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...
  3. NM_012238.5NP_036370.2  NAD-dependent protein deacetylase sirtuin-1 isoform a

    See identical proteins and their annotated locations for NP_036370.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AL133551
    Consensus CDS
    CCDS7273.1
    UniProtKB/Swiss-Prot
    Q96EB6
    UniProtKB/TrEMBL
    A0A024QZQ1
    Related
    ENSP00000212015.6, ENST00000212015.10
    Conserved Domains (1) summary
    cd01408
    Location:254489
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    67884669..67918390
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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