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Sirt1 sirtuin 1 [ Mus musculus (house mouse) ]

Gene ID: 93759, updated on 1-Mar-2024

Summary

Official Symbol
Sirt1provided by MGI
Official Full Name
sirtuin 1provided by MGI
Primary source
MGI:MGI:2135607
See related
Ensembl:ENSMUSG00000020063 AllianceGenome:MGI:2135607
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2; Sir2a; SIR2L1; Sir2alpha
Summary
This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 26 other tissues See more
Orthologs
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Genomic context

See Sirt1 in Genome Data Viewer
Location:
10 B4; 10 32.57 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (63154784..63174814, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (63319005..63339035, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700120B22 gene Neighboring gene hect domain and RLD 4 Neighboring gene predicted gene, 51767 Neighboring gene Sirt1 promoter region Neighboring gene STARR-seq mESC enhancer starr_26931 Neighboring gene STARR-seq mESC enhancer starr_26932 Neighboring gene STARR-positive B cell enhancer ABC_E5142 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene calcyclin binding protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC150273

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables HLH domain binding ISO
Inferred from Sequence Orthology
more info
 
enables NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD+ binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD-dependent histone H3K14 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone H3K9 deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone H3K9 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone H4K16 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables NAD-dependent histone decrotonylase activity ISO
Inferred from Sequence Orthology
more info
 
enables NAD-dependent protein deacetylase activity EXP
Inferred from Experiment
more info
PubMed 
enables NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone H3K deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone H4K12 deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables histone binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables keratin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables nuclear receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables promoter-specific chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
enables protein lysine deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein lysine deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein lysine deacetylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables protein-propionyllysine depropionylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA repair-dependent chromatin remodeling ISO
Inferred from Sequence Orthology
more info
 
involved_in DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in cellular response to resveratrol ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chromatin organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chromatin remodeling ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heterochromatin formation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in intracellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of nucleus location ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of attachment of mitotic spindle microtubules to kinetochore ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of triglyceride biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
involved_in neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within ovulation from ovarian follicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of double-strand break repair ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gluconeogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of skeletal muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of thyroid-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein depropionylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in pyrimidine dimer repair by nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pyrimidine dimer repair by nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
involved_in rDNA heterochromatin formation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of bile acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of centrosome duplication ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by glucose ISO
Inferred from Sequence Orthology
more info
 
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
 
involved_in response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
involved_in response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to leptin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
involved_in single strand break repair ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
involved_in transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in vasodilation ISO
Inferred from Sequence Orthology
more info
 
involved_in white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of eNoSc complex ISO
Inferred from Sequence Orthology
more info
 
part_of euchromatin ISO
Inferred from Sequence Orthology
more info
 
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
part_of heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
part_of heterochromatin ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-1
Names
NAD-dependent protein deacylase sirtuin-1
SIR2-like protein 1
regulatory protein SIR2 homolog 1
sirtuin 1 ((silent mating type information regulation 2, homolog) 1
NP_001153061.1
NP_062786.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159589.2NP_001153061.1  NAD-dependent protein deacetylase sirtuin-1 isoform 2

    See identical proteins and their annotated locations for NP_001153061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
    Consensus CDS
    CCDS48585.1
    UniProtKB/TrEMBL
    A7MCT8, Q3UNI1
    Related
    ENSMUSP00000101082.3, ENSMUST00000105442.3
    Conserved Domains (1) summary
    cd01408
    Location:207442
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_019812.3NP_062786.1  NAD-dependent protein deacetylase sirtuin-1 isoform 1

    See identical proteins and their annotated locations for NP_062786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
    Consensus CDS
    CCDS23898.1
    UniProtKB/Swiss-Prot
    Q923E4, Q9QXG8
    UniProtKB/TrEMBL
    Q53Z05
    Related
    ENSMUSP00000020257.7, ENSMUST00000020257.13
    Conserved Domains (1) summary
    cd01408
    Location:246481
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    63154784..63174814 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001159590.1: Suppressed sequence

    Description
    NM_001159590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.