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Sirt1 sirtuin 1 [ Mus musculus (house mouse) ]

Gene ID: 93759, updated on 11-Nov-2018

Summary

Official Symbol
Sirt1provided by MGI
Official Full Name
sirtuin 1provided by MGI
Primary source
MGI:MGI:2135607
See related
Ensembl:ENSMUSG00000020063 Vega:OTTMUSG00000030914
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Sir2; Sir2a; SIR2L1; AA673258; Sir2alpha
Summary
This gene encodes a member of the sirtuin family of proteins, characterized by their deacetylase activity and proposed role in longevity. The encoded protein regulates gene expression in a wide range of cell and tissue types through its NAD+-dependent deacetylation of histones, transcription factors and transcriptional coactivators. Brain-specific overexpression of this gene has been shown to result in increased median lifespan. Viability of homozygous knockout mice for this gene varies with strain background. Homozygous knockout mice of strains that do not exhibit embryonic lethality are sterile and have a reduced lifespan. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 7.7), limb E14.5 (RPKM 5.8) and 26 other tissues See more
Orthologs

Genomic context

See Sirt1 in Genome Data Viewer
Location:
10; 10 B4
Exon count:
9
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 10 NC_000076.6 (63319005..63339035, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 10 NC_000076.5 (62781753..62801783, complement)

Chromosome 10 - NC_000076.6Genomic Context describing neighboring genes Neighboring gene myopalladin Neighboring gene hect domain and RLD 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member C12 Neighboring gene calcyclin binding protein pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC150273

Gene Ontology Provided by MGI

Function Evidence Code Pubs
HLH domain binding ISO
Inferred from Sequence Orthology
more info
 
NAD+ binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
NAD-dependent histone deacetylase activity (H3-K9 specific) IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity EXP
Inferred from Experiment
more info
PubMed 
NAD-dependent protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
NAD-dependent protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
RNA polymerase II distal enhancer sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
bHLH transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bHLH transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
enzyme binding ISO
Inferred from Sequence Orthology
more info
 
histone binding ISO
Inferred from Sequence Orthology
more info
 
histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
 
hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
identical protein binding ISO
Inferred from Sequence Orthology
more info
 
keratin filament binding ISO
Inferred from Sequence Orthology
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
mitogen-activated protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
nuclear hormone receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear hormone receptor binding ISO
Inferred from Sequence Orthology
more info
 
p53 binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
p53 binding ISO
Inferred from Sequence Orthology
more info
 
protein C-terminus binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein C-terminus binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
protein domain specific binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase B binding ISO
Inferred from Sequence Orthology
more info
 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
DNA synthesis involved in DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
UV-damage excision repair ISO
Inferred from Sequence Orthology
more info
 
angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
angiogenesis ISO
Inferred from Sequence Orthology
more info
 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
behavioral response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cellular glucose homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
cellular response to hypoxia ISO
Inferred from Sequence Orthology
more info
 
cellular response to ionizing radiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to tumor necrosis factor ISO
Inferred from Sequence Orthology
more info
 
cellular triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chromatin organization ISO
Inferred from Sequence Orthology
more info
 
chromatin silencing at rDNA ISO
Inferred from Sequence Orthology
more info
 
circadian regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
circadian rhythm IEP
Inferred from Expression Pattern
more info
PubMed 
energy homeostasis ISO
Inferred from Sequence Orthology
more info
 
establishment of chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
fatty acid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
histone H3 deacetylation ISO
Inferred from Sequence Orthology
more info
 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylation IGI
Inferred from Genetic Interaction
more info
PubMed 
histone deacetylation ISO
Inferred from Sequence Orthology
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
leptin-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage cytokine production IMP
Inferred from Mutant Phenotype
more info
PubMed 
macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
muscle organ development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA damage response, signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
negative regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of I-kappaB kinase/NF-kappaB signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of TOR signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of TOR signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cardiac muscle cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular response to testosterone stimulus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
negative regulation of fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
negative regulation of growth hormone secretion ISO
Inferred from Sequence Orthology
more info
 
negative regulation of helicase activity ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone H3-K14 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of histone H3-K9 trimethylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of histone H4-K16 acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of neuron death IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
negative regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of phosphorylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of prostaglandin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein acetylation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein kinase B signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein kinase B signaling ISO
Inferred from Sequence Orthology
more info
 
negative regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
 
negative regulation of reactive oxygen species biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
 
ovulation from ovarian follicle IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
 
peptidyl-lysine deacetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of DNA repair ISO
Inferred from Sequence Orthology
more info
 
positive regulation of MHC class II biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adaptive immune response ISO
Inferred from Sequence Orthology
more info
 
positive regulation of adipose tissue development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel diameter ISO
Inferred from Sequence Orthology
more info
 
positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cellular senescence ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cholesterol efflux IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of chromatin silencing ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of heart rate ISO
Inferred from Sequence Orthology
more info
 
positive regulation of histone H3-K9 methylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
positive regulation of macrophage apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of skeletal muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of thyroid-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
protein deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
protein deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deacetylation ISO
Inferred from Sequence Orthology
more info
 
protein destabilization IDA
Inferred from Direct Assay
more info
PubMed 
protein destabilization ISO
Inferred from Sequence Orthology
more info
 
protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
pyrimidine dimer repair by nucleotide-excision repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
pyrimidine dimer repair by nucleotide-excision repair ISO
Inferred from Sequence Orthology
more info
 
rRNA processing IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
regulation of bile acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of brown fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of endodeoxyribonuclease activity ISO
Inferred from Sequence Orthology
more info
 
regulation of glucose metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lipid storage IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
 
regulation of peroxisome proliferator activated receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein import into nucleus, translocation ISO
Inferred from Sequence Orthology
more info
 
regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
regulation of smooth muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
response to ethanol ISO
Inferred from Sequence Orthology
more info
 
response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
 
response to insulin IDA
Inferred from Direct Assay
more info
PubMed 
response to leptin IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
single strand break repair ISO
Inferred from Sequence Orthology
more info
 
spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
stress-induced premature senescence ISO
Inferred from Sequence Orthology
more info
 
transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
triglyceride mobilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
white fat cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with ESC/E(Z) complex ISO
Inferred from Sequence Orthology
more info
 
PML body ISO
Inferred from Sequence Orthology
more info
 
axon ISO
Inferred from Sequence Orthology
more info
 
chromatin IDA
Inferred from Direct Assay
more info
PubMed 
chromatin silencing complex ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol ISO
Inferred from Sequence Orthology
more info
 
growth cone ISO
Inferred from Sequence Orthology
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion ISO
Inferred from Sequence Orthology
more info
 
nuclear chromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear envelope ISO
Inferred from Sequence Orthology
more info
 
nuclear euchromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear euchromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
nuclear heterochromatin ISO
Inferred from Sequence Orthology
more info
 
nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear inner membrane ISO
Inferred from Sequence Orthology
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus ISO
Inferred from Sequence Orthology
more info
 
rDNA heterochromatin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rDNA heterochromatin ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
NAD-dependent protein deacetylase sirtuin-1
Names
SIR2-like protein 1
regulatory protein SIR2 homolog 1
sirtuin 1 ((silent mating type information regulation 2, homolog) 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159589.2NP_001153061.1  NAD-dependent protein deacetylase sirtuin-1 isoform 2

    See identical proteins and their annotated locations for NP_001153061.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
    Consensus CDS
    CCDS48585.1
    UniProtKB/TrEMBL
    Q3UNI1, Q3USJ2, Q3USY7
    Related
    ENSMUSP00000101082.2, OTTMUSP00000040278, ENSMUST00000105442.2, OTTMUST00000076494
    Conserved Domains (1) summary
    cd01408
    Location:207442
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
  2. NM_019812.3NP_062786.1  NAD-dependent protein deacetylase sirtuin-1 isoform 1

    See identical proteins and their annotated locations for NP_062786.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC153516, AK139946, AK140330, AK141245, BE989110, BX523319
    Consensus CDS
    CCDS23898.1
    UniProtKB/Swiss-Prot
    Q923E4
    UniProtKB/TrEMBL
    Q3USJ2, Q3USY7, Q53Z05
    Related
    ENSMUSP00000020257.6, ENSMUST00000020257.12
    Conserved Domains (1) summary
    cd01408
    Location:246481
    SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000076.6 Reference GRCm38.p4 C57BL/6J

    Range
    63319005..63339035 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001159590.1: Suppressed sequence

    Description
    NM_001159590.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center