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TOM1L1 target of myb1 like 1 membrane trafficking protein [ Homo sapiens (human) ]

Gene ID: 10040, updated on 5-Aug-2018

Summary

Official Symbol
TOM1L1provided by HGNC
Official Full Name
target of myb1 like 1 membrane trafficking proteinprovided by HGNC
Primary source
HGNC:HGNC:11983
See related
Ensembl:ENSG00000141198 MIM:604701; Vega:OTTHUMG00000177816
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SRCASM
Expression
Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues See more
Orthologs

Genomic context

See TOM1L1 in Genome Data Viewer
Location:
17q22
Exon count:
17
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (54900691..54961967)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (52977880..53039328)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene RNA, 7SK small nuclear pseudogene 14 Neighboring gene protein GVQW1-like Neighboring gene cytochrome c oxidase copper chaperone COX11 Neighboring gene syntaxin binding protein 4 Neighboring gene uncharacterized LOC107985002 Neighboring gene VISTA enhancer hs2291 Neighboring gene HLF, PAR bZIP transcription factor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag The PTAP sequence (179-182) in the GAT domain and the PSAP sequence (310-313) in the C-terminal region of Tom1L1 are required for its interaction with the UEV domain (1-145) of Tsg101 and competes with HIV-1 Gag PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
clathrin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin binding TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
Golgi stack IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
lysosome TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
TOM1-like protein 1
Names
src-activating and signaling molecule protein
target of Myb-like protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321173.1NP_001308102.1  TOM1-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB065085, BC029396, BX110664, DC362418
    Consensus CDS
    CCDS82160.1
    UniProtKB/Swiss-Prot
    O75674
    UniProtKB/TrEMBL
    Q8NI65
    Related
    ENSP00000458918.1, OTTHUMP00000257707, ENST00000575333.5, OTTHUMT00000439063
    Conserved Domains (2) summary
    cd03565
    Location:14154
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14237
    Location:199290
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)
  2. NM_001321174.1NP_001308103.1  TOM1-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK315907, AW044673, CB241257, DC362418
    Consensus CDS
    CCDS82161.1
    UniProtKB/Swiss-Prot
    O75674
    Related
    ENSP00000443099.1, OTTHUMP00000257705, ENST00000536554.5, OTTHUMT00000439061
    Conserved Domains (2) summary
    cd14237
    Location:122213
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)
    cl02544
    Location:177
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  3. NM_001321175.1NP_001308104.1  TOM1-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007485, AC090824, AW044673, DC362418
    Consensus CDS
    CCDS82161.1
    UniProtKB/Swiss-Prot
    O75674
    Conserved Domains (2) summary
    cd14237
    Location:122213
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)
    cl02544
    Location:177
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  4. NM_001321176.1NP_001308105.1  TOM1-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC007485, AC090824, AW044673, DC362418
    Consensus CDS
    CCDS82161.1
    UniProtKB/Swiss-Prot
    O75674
    Conserved Domains (2) summary
    cd14237
    Location:122213
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)
    cl02544
    Location:177
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
  5. NM_005486.2NP_005477.2  TOM1-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_005477.2

    Status: VALIDATED

    Source sequence(s)
    AJ010071, AK223125, AK315039, AW044673, AW139144, CN284148
    Consensus CDS
    CCDS11582.1
    UniProtKB/Swiss-Prot
    O75674
    Related
    ENSP00000460823.1, OTTHUMP00000257689, ENST00000575882.5, OTTHUMT00000439029
    Conserved Domains (2) summary
    cd03565
    Location:14154
    VHS_Tom1; VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of ...
    cd14237
    Location:199290
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    54900691..54961967
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024002.1XP_016879491.1  TOM1-like protein 1 isoform X1

    UniProtKB/Swiss-Prot
    O75674
    Conserved Domains (2) summary
    cd14237
    Location:122213
    GAT_TM1L1; GAT domain found in target of Myb-like protein 1 (Tom1L1)
    cl02544
    Location:177
    VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...

RNA

  1. XR_243612.3 RNA Sequence

  2. XR_001752397.2 RNA Sequence

  3. XR_002957936.1 RNA Sequence

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