1ELK


Conserved Protein Domain Family
VHS_Tom1
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cd03565: VHS_Tom1 (this model, PSSM-Id:239623 is obsolete and has been replaced by 340768)
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VHS domain family, Tom1 subfamily; The VHS domain is an essential part of Tom1 (Target of myb1 - retroviral oncogene) protein. The VHS domain has a superhelical structure similar to the structure of the ARM repeats and is present at the very N-termini of proteins. It is a right-handed superhelix of eight alpha helices. The VHS domain has been found in a number of proteins, some of which have been implicated in intracellular trafficking and sorting. The VHS domain of the Tom1 protein is essential for the negative regulation of Interleukin-1 and Tumor Necrosis Factor-induced signaling pathways.
Links
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Statistics
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PSSM-Id: 239623
Aligned: 10 rows
Threshold Bit Score: 254.269
Created: 2-Mar-2006
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
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putativeputative
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:putative intraprotein/interprotein binding site
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                         ##  #   #                                          ##        
1ELK_A      16 PVGQRIEKATDGS-LQSEDWALNMEICDIINETEEGPKDALRAVKKRI--VGNKNFHEVMLALTVLETCVKNCGHRFHVL 92   human
NP_648315   17 PVGQRIEAATDAN-LASENWAANMEICDMINESSDTARDAMRAIRKRLsqNAGKNNQVVMYTLTVLETCVKNCGKAFHVL 95   fruit fly
7495586     38 PVGRKIELATDANlLATENWGLNMEICDFINGTEDGPRDAVRALKKRLhnAMSKNNAVVMYTLTVLETAVKNCNHHFHVL 117  Caenorhabditis e...
XP_783741   12 PVGQRIERATNES-QASEDWGLIMEITDIINETEEGAKDAVKALKKRL--FGNKKWKEVIFSLTILETCVKNCQHRFHVP 88   purple urchin
XP_414813  477 TAFLHVEKATDGS-LQSEDWTLNMEICDIINETEEGPKDAIRALKKRL--NGNKNYREVMLALTVLETCVKNCGHRFHVL 553  chicken
XP_688819   12 PVGHCIERATDGS-LQSEDWTLNMEICDIINETEDGPKDAMRAVKKRL--NGNKNYREVMLTLTVLETCVKNCGYRFHML 88   zebrafish
XP_415646  172 AVGSLVERATFGS-LQTEEWGQFMHICDVINATEEGPKDAVKALKKKL--SKNCNHKEIRLTLSLLDMCMQNCGPRFQSL 248  chicken
BAD96845    14 SVGHLIEKATFAG-VQTEDWGQFMHICDIINTTQDGPKDAVKALKKRI--SKNYNHKEIQLTLSLIDMCVQNCGPSFQSL 90   human
AAH42344    14 PVGHLIDIHTVGT-LQKEEWGQFMNICDAINSTADGPKDAVKAFKKRI--CRNYNQKEVKFSLSLLEMCMQNCVPNFQSL 90   African clawed frog
AAH79756    12 PVGQCIEKATDGS-LQSEDWTLNMEICDIINETEEGPKDAMRALKKRL--NGNRNYREVMLALTVLETCVKNCGHRFHVQ 88   African clawed frog

Feature 1                                                                      
1ELK_A      93 VASQDFVESvLVRTILPKNNPPTIVHDKVLNLIQSWADAFRSspDLTGVVTIYEDLRRKGLEFP 156  human
NP_648315   96 VAQKDFINE-LVKLIGPKNDPPAAMQEKVLSLIQIWADAFKNqpDLNGVTQMYMELKNKGIEFP 158  fruit fly
7495586    118 VCNKDFVQD-LIKLIGPKFDAPQIIQERVLSLIQAWADAFRGdpTLAGVVQSYDDLKSKGVEFP 180  Caenorhabditis elegans
XP_783741   89 ICKQEFCKE-LVKVIQPNLNPPTIVQEKILGLIQSWADAFKNdpTLQGVVKVYEELKSKSIEFP 151  purple urchin
XP_414813  554 VANRDFIDGvLVKIISPKNNPPTIVQDKVLALIQAWADAFRSspDLTGVVHIYEELKRKGIEFP 617  chicken
XP_688819   89 VTTRDFIDGvLVKIISPKNNPPAIVQDKVLALIQAWADAFRSspDLTGVVHVYEEMKRKGIEFP 152  zebrafish
XP_415646  249 VVKKDFCKDkLVKLLNPRYNLPIDLQEKILTFIMIWARGFQGmvDVTEVKEVYLELLKKGVEFP 312  chicken
BAD96845    91 IVKKEFVKEnLVKLLNPRYNLPLDIQNRILNFIKTWSQGFPGgvDVSEVKEVYLDLVKKGVQFP 154  human
AAH42344    91 VLKKDFSKDvLVKMLNPKYNLPVSLQNKILYLIMTWAHGLKGkvDAMEIREVYLELIKRGIKFP 154  African clawed frog
AAH79756    89 VTHRDFIDGiLVKIISPKNNPPTIVQDKVLALIQAWADAFRSspDLTGVVHIYEELKRKGIEFP 152  African clawed frog

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