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YAP1 Yes1 associated transcriptional regulator [ Bos taurus (domestic cattle) ]

Gene ID: 100336629, updated on 17-Aug-2024

Summary

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Official Symbol
YAP1provided by VGNC
Official Full Name
Yes1 associated transcriptional regulatorprovided by VGNC
Primary source
VGNC:VGNC:57367
See related
Ensembl:ENSBTAG00000039307
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 15
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 15 NC_037342.1 (6499364..6634778, complement)

Chromosome 15 - NC_037342.1Genomic Context describing neighboring genes Neighboring gene small ribosomal subunit protein eS17-like Neighboring gene uncharacterized LOC100848148 Neighboring gene proline-rich nuclear receptor coactivator 2-like Neighboring gene cilia and flagella associated protein 300 Neighboring gene small nucleolar RNA SNORA57

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037342.1 Chromosome 15 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells. Yamamura S, et al. Dev Biol, 2020 Dec 1. PMID 32946790
  2. Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway. Yu B, et al. Int J Mol Sci, 2021 May 31. PMID 34072880, Free PMC Article
  3. A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses. Kusama K, et al. Domest Anim Endocrinol, 2016 Oct. PMID 27315596

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway.
    Title: Lysophosphatidic Acid Accelerates Bovine In Vitro-Produced Blastocyst Formation through the Hippo/YAP Pathway.
  2. Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells.
    Title: Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells.
  3. The data suggest that TEAD relocation and/or YAP degradation following its phosphorylation down-regulates IFNT gene transcription after conceptus attachment to the uterine endometrium.
    Title: A transcriptional cofactor YAP regulates IFNT expression via transcription factor TEAD in bovine conceptuses.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transcription corepressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hippo signaling IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
transcriptional coactivator YAP1
Names
Yes associated protein 1
Yes-associated protein 1, 65kDa
yorkie homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037342.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    6499364..6634778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024975715.2 → XP_024831483.1  transcriptional coactivator YAP1 isoform X12

    Conserved Domains (1) summary
    smart00456
    Location:171 → 202
    WW; Domain with 2 conserved Trp (W) residues

  2. XM_024975713.2 → XP_024831481.1  transcriptional coactivator YAP1 isoform X10

    Conserved Domains (1) summary
    smart00456
    Location:171 → 202
    WW; Domain with 2 conserved Trp (W) residues

  3. XM_024975714.2 → XP_024831482.1  transcriptional coactivator YAP1 isoform X11

    Conserved Domains (1) summary
    cd00201
    Location:173 → 202
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  4. XM_024975712.2 → XP_024831480.1  transcriptional coactivator YAP1 isoform X9

    UniProtKB/TrEMBL
    A0AAA9SB49
    Related
    ENSBTAP00000079410.1, ENSBTAT00000088398.1
    Conserved Domains (1) summary
    smart00456
    Location:171 → 202
    WW; Domain with 2 conserved Trp (W) residues

  5. XM_024975711.2 → XP_024831479.1  transcriptional coactivator YAP1 isoform X8

    Conserved Domains (2) summary
    smart00456
    Location:230 → 262
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:173 → 202
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  6. XM_024975709.2 → XP_024831477.1  transcriptional coactivator YAP1 isoform X4

    Conserved Domains (2) summary
    smart00456
    Location:230 → 262
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:173 → 202
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  7. XM_024975710.2 → XP_024831478.1  transcriptional coactivator YAP1 isoform X6

    Conserved Domains (2) summary
    smart00456
    Location:230 → 262
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:173 → 202
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  8. XM_024975708.2 → XP_024831476.1  transcriptional coactivator YAP1 isoform X2

    Conserved Domains (2) summary
    smart00456
    Location:230 → 262
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:173 → 202
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

  9. XM_059875063.1 → XP_059731046.1  transcriptional coactivator YAP1 isoform X7

  10. XM_059875060.1 → XP_059731043.1  transcriptional coactivator YAP1 isoform X3

  11. XM_059875062.1 → XP_059731045.1  transcriptional coactivator YAP1 isoform X5

    UniProtKB/TrEMBL
    A0AAA9T554
    Related
    ENSBTAP00000091666.1, ENSBTAT00000116182.1

  12. XM_059875059.1 → XP_059731042.1  transcriptional coactivator YAP1 isoform X1

    UniProtKB/TrEMBL
    F1MK73
    Related
    ENSBTAP00000006112.7, ENSBTAT00000006112.7
Nucleotide Protein
Heading Accession and Version

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