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YAP1 Yes associated protein 1 [ Homo sapiens (human) ]

Gene ID: 10413, updated on 16-Sep-2018

Summary

Official Symbol
YAP1provided by HGNC
Official Full Name
Yes associated protein 1provided by HGNC
Primary source
HGNC:HGNC:16262
See related
Ensembl:ENSG00000137693 MIM:606608; Vega:OTTHUMG00000167322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YAP; YKI; COB1; YAP2; YAP65
Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in thyroid (RPKM 45.0), endometrium (RPKM 38.7) and 23 other tissues See more
Orthologs

Genomic context

See YAP1 in Genome Data Viewer
Location:
11q22.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (102109957..102233423)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (101981151..102104154)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene centrosomal protein 126 Neighboring gene proline rich 21 pseudogene Neighboring gene cilia and flagella associated protein 300 Neighboring gene RNA, 5S ribosomal pseudogene 535 Neighboring gene uncharacterized LOC105369460 Neighboring gene ribosomal protein S6 pseudogene 17

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Coloboma, ocular, with or without hearing impairment, cleft lip/palate, and/or mental retardation
MedGen: C1852750 OMIM: 120433 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2014-11-13)

ClinGen Genome Curation Page
Haploinsufficency

Little evidence for dosage pathogenicity (Last evaluated (2014-11-13)

ClinGen Genome Curation PagePubMed

NHGRI GWAS Catalog

Description
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
NHGRI GWA Catalog
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome.
NHGRI GWA Catalog
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.
NHGRI GWA Catalog
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
NHGRI GWA Catalog

Pathways from BioSystems

  • ErbB4 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    ErbB4 signaling events, organism-specific biosystem
    ErbB4 signaling events
  • Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystem (from REACTOME)
    Fatty acid, triacylglycerol, and ketone body metabolism, organism-specific biosystemThe reactions involved in the metabolism of fatty acids and of the triacylglycerols and ketone bodies derived from them form a closely interrelated, coordinately regulated module that plays a central...
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Hippo signaling, organism-specific biosystem (from KEGG)
    Hippo signaling, organism-specific biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling, conserved biosystem (from KEGG)
    Hippo signaling, conserved biosystemFunctional set; Cellular processes; Cell signaling
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway -multiple species, organism-specific biosystem (from KEGG)
    Hippo signaling pathway -multiple species, organism-specific biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Hippo signaling pathway -multiple species, conserved biosystem (from KEGG)
    Hippo signaling pathway -multiple species, conserved biosystemHippo signaling pathways control diverse aspects of cell proliferation, survival, and morphogenesis in eukaryotes. The core organization of these networks is conserved over a billion years of evoluti...
  • Mesodermal Commitment Pathway, organism-specific biosystem (from WikiPathways)
    Mesodermal Commitment Pathway, organism-specific biosystemModel depicting mesodermal specification based on the literature and highly enriched gene expression profiles via comparison across dozens of independent induced and embryonic pluripotent stem cell l...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Nuclear signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Nuclear signaling by ERBB4, organism-specific biosystemBesides signaling as a transmembrane receptor, ligand activated homodimers of ERBB4 JM-A isoforms (ERBB4 JM-A CYT1 and ERBB4 JM-A CYT2) undergo proteolytic cleavage by ADAM17 (TACE) in the juxtamembr...
  • PPARA activates gene expression, organism-specific biosystem (from REACTOME)
    PPARA activates gene expression, organism-specific biosystemThe set of genes regulated by PPAR-alpha is not fully known in humans, however many examples have been found in mice. Genes directly activated by PPAR-alpha contain peroxisome proliferator receptor e...
  • Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystem (from WikiPathways)
    Rac1/Pak1/p38/MMP-2 pathway, organism-specific biosystemRac1/p38 pathway from Ingenuity Pathway Analysis.
  • Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystem (from REACTOME)
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha), organism-specific biosystemPeroxisome proliferator-activated receptor alpha (PPAR-alpha) is the major regulator of fatty acid oxidation in the liver. PPARalpha is also the target of fibrate drugs used to treat abnormal plasma ...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by ERBB4, organism-specific biosystem (from REACTOME)
    Signaling by ERBB4, organism-specific biosystemERBB4, also known as HER4, belongs to the ERBB family of receptors, which also includes ERBB1 (EGFR i.e. HER1), ERBB2 (HER2 i.e. NEU) and ERBB3 (HER3). Similar to EGFR, ERBB4 has an extracellular lig...
  • Signaling by Hippo, organism-specific biosystem (from REACTOME)
    Signaling by Hippo, organism-specific biosystemHuman Hippo signaling is a network of reactions that regulates cell proliferation and apoptosis, centered on a three-step kinase cascade. The cascade was discovered by analysis of Drosophila mutation...
  • TGF-beta Signaling Pathway, organism-specific biosystem (from WikiPathways)
    TGF-beta Signaling Pathway, organism-specific biosystemThe signal transduction mechanisms underlying the pathophysiological activities of transforming growth factor-? (TGF-?) have been extensively studied since its discovery nearly 30 years ago. TGF-? li...
  • TGF-beta receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    TGF-beta receptor signaling, organism-specific biosystem
    TGF-beta receptor signaling
  • YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystem (from REACTOME)
    YAP1- and WWTR1 (TAZ)-stimulated gene expression, organism-specific biosystemYAP1 and WWTR1 (TAZ) are transcriptional co-activators, both homologues of the Drosophila Yorkie protein. They both interact with members of the TEAD family of transcription factors, and WWTR1 intera...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
activating transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
proline-rich region binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
bud elongation involved in lung branching IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle tissue regeneration IEA
Inferred from Electronic Annotation
more info
 
cell morphogenesis IEA
Inferred from Electronic Annotation
more info
 
cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to gamma radiation IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to retinoic acid IEA
Inferred from Electronic Annotation
more info
 
contact inhibition IDA
Inferred from Direct Assay
more info
PubMed 
embryonic heart tube morphogenesis IEA
Inferred from Electronic Annotation
more info
 
heart process IEA
Inferred from Electronic Annotation
more info
 
hippo signaling TAS
Traceable Author Statement
more info
PubMed 
keratinocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
lateral mesoderm development IEA
Inferred from Electronic Annotation
more info
 
lung epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of nucleic acid-templated transcription IEA
Inferred from Electronic Annotation
more info
 
negative regulation of stem cell differentiation IEA
Inferred from Electronic Annotation
more info
 
notochord development IEA
Inferred from Electronic Annotation
more info
 
paraxial mesoderm development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of canonical Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of intracellular estrogen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
progesterone receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of keratinocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
regulation of metanephric nephron tubule epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
regulation of neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
regulation of stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
response to progesterone IDA
Inferred from Direct Assay
more info
PubMed 
somatic stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
vasculogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
TEAD-1-YAP complex IDA
Inferred from Direct Assay
more info
PubMed 
TEAD-2-YAP complex IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
transcriptional coactivator YAP1
Names
65 kDa Yes-associated protein
protein yorkie homolog
yes-associated protein 1
yes-associated protein 2
yes-associated protein YAP65 homolog
yorkie homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029530.1 RefSeqGene

    Range
    5001..127963
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001130145.2NP_001123617.1  transcriptional coactivator YAP1 isoform 1

    See identical proteins and their annotated locations for NP_001123617.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 9. The encoded protein (isoform 1) represents the YAP1-2gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, BC038235
    Consensus CDS
    CCDS44716.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000282441.5, OTTHUMP00000235695, ENST00000282441.9, OTTHUMT00000394151
    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  2. NM_001195044.1NP_001181973.1  transcriptional coactivator YAP1 isoform 3

    See identical proteins and their annotated locations for NP_001181973.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site and lacks an alternate exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 3) represents the YAP1-2alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, AY316529
    Consensus CDS
    CCDS53699.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000431574.1, OTTHUMP00000235696, ENST00000531439.5, OTTHUMT00000394152
    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  3. NM_001195045.1NP_001181974.1  transcriptional coactivator YAP1 isoform 4

    See identical proteins and their annotated locations for NP_001181974.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple differences in the coding region, compared to variant 9. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (4), compared to isoform 9.
    Source sequence(s)
    AA854862, AI128142, AK316116, AL832620, AP000942, BC038235
    Consensus CDS
    CCDS53700.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000435602.1, OTTHUMP00000235697, ENST00000524575.5, OTTHUMT00000394153
    Conserved Domains (2) summary
    smart00456
    Location:5385
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:125
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  4. NM_001282097.1NP_001269026.1  transcriptional coactivator YAP1 isoform 6

    See identical proteins and their annotated locations for NP_001269026.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon and uses an alternate in-frame splice site in the coding region, compared to variant 9. The encoded protein (isoform 6) represents the YAP1-1gamma isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AB567720, AI128142, AL832620, AP000942, AP001527, BC026212
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Conserved Domains (1) summary
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  5. NM_001282098.1NP_001269027.1  transcriptional coactivator YAP1 isoform 5

    See identical proteins and their annotated locations for NP_001269027.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks two alternate in-frame exons in the coding region, compared to variant 9. The encoded protein (isoform 5) represents the YAP1-1beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864159
    Consensus CDS
    CCDS60945.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    A0A024R3E4, Q86T74
    Related
    ENSP00000487519.1, OTTHUMP00000278710, ENST00000629586.2, OTTHUMT00000482753
    Conserved Domains (1) summary
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  6. NM_001282099.1NP_001269028.1  transcriptional coactivator YAP1 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the coding region, compared to variant 9. The encoded protein (isoform 7) represents the YAP1-1delta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864161
    Consensus CDS
    CCDS73374.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000331023.4, ENST00000345877.6
    Conserved Domains (1) summary
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  7. NM_001282100.1NP_001269029.1  transcriptional coactivator YAP1 isoform 8

    See identical proteins and their annotated locations for NP_001269029.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate in-frame exon in the 3' coding region, compared to variant 9. The encoded protein (isoform 8) represents the YAP1-2beta isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AB567720, AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864162
    Consensus CDS
    CCDS60944.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000445635.1, ENST00000537274.5
    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  8. NM_001282101.1NP_001269030.1  transcriptional coactivator YAP1 isoform 9

    See identical proteins and their annotated locations for NP_001269030.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) represents the longest transcript and encodes the longest isoform (9). The encoded protein represents the YAP1-2delta isoform described in Figure 3 of PMID: 22939869.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, BC026212, BC038235, HE864163
    Consensus CDS
    CCDS73373.1
    UniProtKB/Swiss-Prot
    P46937
    UniProtKB/TrEMBL
    K0KVU2, Q86T74
    Related
    ENSP00000478927.1, ENST00000615667.4
    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  9. NM_006106.4NP_006097.2  transcriptional coactivator YAP1 isoform 2

    See identical proteins and their annotated locations for NP_006097.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site and lacks two alternate exons in the coding region, compared to variant 9. The encoded protein (isoform 2) represents the YAP1-1alpha isoform described in Figure 3 of PMID: 22939869. It is shorter, compared to isoform 9.
    Source sequence(s)
    AI128142, AL832620, AP000942, AP001527, AP002777
    Consensus CDS
    CCDS8314.2
    UniProtKB/TrEMBL
    Q86T74
    Related
    ENSP00000434134.1, OTTHUMP00000235694, ENST00000526343.5, OTTHUMT00000394150
    Conserved Domains (1) summary
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    102109957..102233423
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005271378.3XP_005271435.1  transcriptional coactivator YAP1 isoform X1

    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  2. XM_005271380.3XP_005271437.1  transcriptional coactivator YAP1 isoform X2

    See identical proteins and their annotated locations for XP_005271437.1

    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  3. XM_005271383.3XP_005271440.1  transcriptional coactivator YAP1 isoform X4

    See identical proteins and their annotated locations for XP_005271440.1

    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  4. XM_005271381.3XP_005271438.1  transcriptional coactivator YAP1 isoform X3

    Conserved Domains (2) summary
    smart00456
    Location:231263
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:174203
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  5. XM_011542556.2XP_011540858.1  transcriptional coactivator YAP1 isoform X6

    See identical proteins and their annotated locations for XP_011540858.1

    Conserved Domains (2) summary
    smart00456
    Location:5385
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:125
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  6. XM_017017093.1XP_016872582.1  transcriptional coactivator YAP1 isoform X7

    Conserved Domains (2) summary
    smart00456
    Location:5385
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:125
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  7. XM_011542555.2XP_011540857.1  transcriptional coactivator YAP1 isoform X5

    See identical proteins and their annotated locations for XP_011540857.1

    Conserved Domains (2) summary
    smart00456
    Location:5385
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:125
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
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