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Yap1 yes-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 22601, updated on 7-Feb-2023

Summary

Official Symbol
Yap1provided by MGI
Official Full Name
yes-associated protein 1provided by MGI
Primary source
MGI:MGI:103262
See related
Ensembl:ENSMUSG00000053110 AllianceGenome:MGI:103262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Yap; Yki; Yap65; Yorkie
Summary
This gene encodes a protein which binds to the SH3 domain of the Yes proto-oncogene product, a tyrosine kinase. This protein contains a WW domain, consisting of four conserved aromatic amino acids including two tryptophan residues. This conserved WW domain is found in various structural, regulatory and signaling molecules in various species, and may play a role in protein-protein interaction. Following cellular damage, phosphorylation of this encoded protein may suppress apoptosis. This protein may be involved in malignant transformation in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]
Expression
Ubiquitous expression in limb E14.5 (RPKM 25.3), bladder adult (RPKM 22.8) and 28 other tissues See more
Orthologs
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Genomic context

See Yap1 in Genome Data Viewer
Location:
9; 9 A1
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (7932000..8004890, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (7931999..8004638, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene baculoviral IAP repeat-containing 2 Neighboring gene baculoviral IAP repeat-containing 3 Neighboring gene cilia and flagella associated protein 300 Neighboring gene centrosomal protein 126

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular function inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables proline-rich region binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of blastocyst development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within bud elongation involved in lung branching IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cardiac muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to DNA damage stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to gamma radiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to retinoic acid IDA
Inferred from Direct Assay
more info
PubMed 
involved_in contact inhibition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within embryonic heart tube morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of enterocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of glandular epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heart process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within hippo signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in hippo signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in interleukin-6-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in intestinal epithelial cell development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in intestinal epithelial cell development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of intestinal epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within keratinocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lung epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of epithelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of epithelial cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of extrinsic apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of stem cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within notochord development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cardiac muscle cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cell growth ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intracellular estrogen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of organ growth IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in progesterone receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of cell population proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of keratinocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of metanephric nephron tubule epithelial cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in response to progesterone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within somatic stem cell population maintenance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of trophectodermal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of TEAD-YAP complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of TEAD-YAP complex ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of transcription regulator complex IGI
Inferred from Genetic Interaction
more info
PubMed 

General protein information

Preferred Names
transcriptional coactivator YAP1
Names
65 kDa Yes-associated protein
Yes-associated protein isoform a474
Yes-associated protein isoform a475
Yes-associated protein isoform a476
Yes-associated protein isoform b309
Yes-associated protein isoform b313
Yes-associated protein isoform b325
protein yorkie homolog
yes-associated protein YAP65 homolog
yes-associated protein, 65 kDa
yorkie homolog

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171147.1NP_001164618.1  transcriptional coactivator YAP1 isoform 1

    See identical proteins and their annotated locations for NP_001164618.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC139885, BC094313, CT030639
    Consensus CDS
    CCDS52718.1
    UniProtKB/Swiss-Prot
    P46938, Q91WL1
    Related
    ENSMUSP00000069554.7, ENSMUST00000065353.13
    Conserved Domains (2) summary
    smart00456
    Location:216248
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
  2. NM_009534.3NP_033560.1  transcriptional coactivator YAP1 isoform 2

    See identical proteins and their annotated locations for NP_033560.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded protein (isoform 2) is shorter, compared to isoform 1.
    Source sequence(s)
    AC139885, BC094313, CT030639
    Consensus CDS
    CCDS40533.1
    UniProtKB/Swiss-Prot
    P46938
    Related
    ENSMUSP00000083772.6, ENSMUST00000086580.12
    Conserved Domains (2) summary
    smart00456
    Location:216248
    WW; Domain with 2 conserved Trp (W) residues
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    7932000..8004890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509856.5XP_006509919.1  transcriptional coactivator YAP1 isoform X5

    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181
  2. XM_006509853.5XP_006509916.1  transcriptional coactivator YAP1 isoform X2

    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181
  3. XM_006509857.5XP_006509920.1  transcriptional coactivator YAP1 isoform X6

    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181
  4. XM_006509854.5XP_006509917.1  transcriptional coactivator YAP1 isoform X3

    Related
    ENSMUSP00000134250.2, ENSMUST00000174604.8
    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181
  5. XM_006509855.5XP_006509918.1  transcriptional coactivator YAP1 isoform X4

    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181
  6. XM_006509852.4XP_006509915.1  transcriptional coactivator YAP1 isoform X1

    Conserved Domains (3) summary
    cd00201
    Location:159188
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:217246
    WW; WW domain
    pfam15238
    Location:61141
    FAM181