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TMED7-TICAM2 TMED7-TICAM2 readthrough [ Homo sapiens (human) ]

Gene ID: 100302736, updated on 4-Dec-2022

Summary

Official Symbol
TMED7-TICAM2provided by HGNC
Official Full Name
TMED7-TICAM2 readthroughprovided by HGNC
Primary source
HGNC:HGNC:33945
See related
Ensembl:ENSG00000251201 AllianceGenome:HGNC:33945
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIRP; TRAM; TICAM2; TIRAP3; MyD88-4; TICAM-2
Summary
This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]
Expression
Ubiquitous expression in endometrium (RPKM 26.4), prostate (RPKM 21.6) and 25 other tissues See more
Orthologs
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Genomic context

See TMED7-TICAM2 in Genome Data Viewer
Location:
5q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115578496..115626036, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116091278..116138818, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114914193..114961733, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene fem-1 homolog C Neighboring gene Sharpr-MPRA regulatory region 5951 Neighboring gene TIR domain containing adaptor molecule 2 Neighboring gene TICAM2 antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC102467217 Neighboring gene uncharacterized LOC124901048

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90737

General protein information

Preferred Names
TRAM adaptor with GOLD domain
Names
Putative NF-kappa-B-activating protein 502
TIR domain-containing adapter molecule 2
TMED7-TICAM2 read-through transcript
Toll-like receptor adaptor protein 3
Toll/interleukin-1 receptor domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164468.4NP_001157940.1  TRAM adaptor with GOLD domain isoform 1 precursor

    See identical proteins and their annotated locations for NP_001157940.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1), also known as TAG. This isoform shares sequence identity with the products of both the TMED7 and TICAM2 genes.
    Source sequence(s)
    AC010226, AY304584
    UniProtKB/Swiss-Prot
    Q86XR7
    Related
    ENSP00000282382.4, ENST00000282382.8
    Conserved Domains (2) summary
    pfam01105
    Location:36189
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
    cl23749
    Location:250341
    TIR_2; TIR domain
  2. NM_001164469.4NP_001157941.1  TRAM adaptor with GOLD domain isoform 2 precursor

    See identical proteins and their annotated locations for NP_001157941.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site that causes an early stop codon in the 3' coding region, compared to variant 1. The encoded isoform (2) has a shorter C-terminus and shares no sequence identity with the downstream TICAM2 gene product, compared to isoform 1.
    Source sequence(s)
    AC010226, AY304583
    UniProtKB/Swiss-Prot
    Q86XR7, Q9Y3B3
    UniProtKB/TrEMBL
    A0A0A6YYA0
    Related
    ENSP00000333650.3, ENST00000333314.3
    Conserved Domains (1) summary
    pfam01105
    Location:36188
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115578496..115626036 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116091278..116138818 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)