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TICAM2 TIR domain containing adaptor molecule 2 [ Homo sapiens (human) ]

Gene ID: 353376, updated on 21-Mar-2023

Summary

Official Symbol
TICAM2provided by HGNC
Official Full Name
TIR domain containing adaptor molecule 2provided by HGNC
Primary source
HGNC:HGNC:21354
See related
Ensembl:ENSG00000243414 MIM:608321; AllianceGenome:HGNC:21354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIRP; TRAM; TIRAP3; MyD88-4; TICAM-2
Summary
Predicted to enable phospholipid binding activity. Involved in several processes, including TRAM-dependent toll-like receptor 4 signaling pathway; regulation of chemokine (C-C motif) ligand 5 production; and regulation of toll-like receptor 4 signaling pathway. Located in endoplasmic reticulum; endosome; and phagocytic cup. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in appendix (RPKM 4.0), spleen (RPKM 3.2) and 25 other tissues See more
Orthologs
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Genomic context

See TICAM2 in Genome Data Viewer
Location:
5q22.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_03 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (115578496..115602479, complement)
RS_2023_03 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (116091278..116115262, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (114914193..114938176, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene chaperonin containing TCP1 subunit 5 pseudogene 1 Neighboring gene fem-1 homolog C Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:114880021-114880787 Neighboring gene TMED7-TICAM2 readthrough Neighboring gene TICAM2 antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 7 Neighboring gene uncharacterized LOC102467217

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Readthrough TMED7-TICAM2

Readthrough gene: TMED7-TICAM2, Included gene: TMED7

Homology

Clone Names

  • MGC129876, MGC129877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables molecular function activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in TRAM-dependent toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in TRIF-dependent toll-like receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in lipopolysaccharide-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling HMP PubMed 
involved_in positive regulation of I-kappaB kinase/NF-kappaB signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of NF-kappaB transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytokine production involved in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of interleukin-18-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of myeloid dendritic cell cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of natural killer cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of toll-like receptor 4 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
TIR domain-containing adapter molecule 2
Names
NF-kappa-B-activating protein 502
TRIF-related adaptor molecule
cytoplasmic adaptor
putative NF-kappa-B-activating protein 502
toll like receptor adaptor molecule 2
toll-like receptor adaptor protein 3
toll/interleukin-1 receptor (TIR) domain-containing adapter protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021649.7NP_067681.1  TIR domain-containing adapter molecule 2

    See identical proteins and their annotated locations for NP_067681.1

    Status: VALIDATED

    Source sequence(s)
    AB097022, AC010226, DA092564, DA992598
    Consensus CDS
    CCDS4119.1
    UniProtKB/Swiss-Prot
    Q6JUT2, Q86XR7
    Related
    ENSP00000415139.3, ENST00000427199.3
    Conserved Domains (1) summary
    cl23749
    Location:81172
    TIR_2; TIR domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_03

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    115578496..115602479 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    116091278..116115262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)