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BCL2L11 BCL2 like 11 [ Homo sapiens (human) ]

Gene ID: 10018, updated on 11-Jun-2021

Summary

Official Symbol
BCL2L11provided by HGNC
Official Full Name
BCL2 like 11provided by HGNC
Primary source
HGNC:HGNC:994
See related
Ensembl:ENSG00000153094 MIM:603827
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM; BIM; BOD
Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues See more
Orthologs
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Genomic context

See BCL2L11 in Genome Data Viewer
Location:
2q13
Exon count:
14
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (111120914..111168445)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111878491..111926022)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase like Neighboring gene Sharpr-MPRA regulatory region 7769 Neighboring gene ACOXL antisense RNA 1 Neighboring gene MIR4435-2 host gene Neighboring gene uncharacterized LOC101927283 Neighboring gene ribosomal protein S14 pseudogene 4

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
GeneReviews: Not available
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
GeneReviews: Not available
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
GeneReviews: Not available
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
GeneReviews: Not available
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
GeneReviews: Not available

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated 2018-06-21)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated 2018-06-21)

ClinGen Genome Curation Page

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells PubMed
tat HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in apoptotic process involved in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in brain development IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to amyloid-beta IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to estradiol stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to glucocorticoid stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
involved_in developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
involved_in ear development IEA
Inferred from Electronic Annotation
more info
 
involved_in extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney development IEA
Inferred from Electronic Annotation
more info
 
involved_in male gonad development IEA
Inferred from Electronic Annotation
more info
 
involved_in mammary gland development IEA
Inferred from Electronic Annotation
more info
 
involved_in meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
involved_in odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process by virus IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of autophagy in response to ER overload IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in positive regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
involved_in positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in post-embryonic animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
involved_in regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in spleen development IEA
Inferred from Electronic Annotation
more info
 
involved_in thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in thymus development IEA
Inferred from Electronic Annotation
more info
 
involved_in tube formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Bcl-2 family protein complex IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
 
located_in extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bcl-2-like protein 11
Names
BCL2-like 11 (apoptosis facilitator)
bcl-2 interacting mediator of cell death
bcl-2 interacting protein Bim
bcl-2-related ovarian death agonist

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029006.1 RefSeqGene

    Range
    5001..52532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

mRNA and Protein(s)

  1. NM_001204106.2NP_001191035.1  bcl-2-like protein 11 isoform 11

    See identical proteins and their annotated locations for NP_001191035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY305714
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4676
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. NM_001204107.1NP_001191036.1  bcl-2-like protein 11 isoform 12

    See identical proteins and their annotated locations for NP_001191036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY423442
    Consensus CDS
    CCDS56132.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481423.1, ENST00000615946.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4673
    Bclx_interact; Bcl-x interacting, BH3 domain
  3. NM_001204108.1NP_001191037.1  bcl-2-like protein 11 isoform 13

    See identical proteins and their annotated locations for NP_001191037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY423443
    Consensus CDS
    CCDS56135.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000482175.1, ENST00000622509.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  4. NM_001204109.2NP_001191038.1  bcl-2-like protein 11 isoform 14

    See identical proteins and their annotated locations for NP_001191038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY428962
    Consensus CDS
    CCDS56136.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481030.1, ENST00000610735.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  5. NM_001204110.2NP_001191039.1  bcl-2-like protein 11 isoform 15

    See identical proteins and their annotated locations for NP_001191039.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849200
    Consensus CDS
    CCDS56133.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000391292.1, ENST00000452231.5
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4673
    Bclx_interact; Bcl-x interacting, BH3 domain
  6. NM_001204111.2NP_001191040.1  bcl-2-like protein 11 isoform 16

    See identical proteins and their annotated locations for NP_001191040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849201
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  7. NM_001204112.2NP_001191041.1  bcl-2-like protein 11 isoform 17

    See identical proteins and their annotated locations for NP_001191041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849202
    Consensus CDS
    CCDS56131.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000393781.1, ENST00000415458.5
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  8. NM_001204113.1NP_001191042.1  bcl-2-like protein 11 isoform 18

    See identical proteins and their annotated locations for NP_001191042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC096670, AK290377, AW629314
    Consensus CDS
    CCDS74559.1
    UniProtKB/Swiss-Prot
    O43521
    UniProtKB/TrEMBL
    A0A0A0MRE7
    Related
    ENSP00000350398.3, ENST00000357757.6
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  9. NM_006538.5NP_006529.1  bcl-2-like protein 11 isoform 6

    See identical proteins and their annotated locations for NP_006529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC096670, AF032458, AI268146, AK290377, BC033694
    Consensus CDS
    CCDS42731.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000309226.8, ENST00000308659.12
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:70106
    Bclx_interact; Bcl-x interacting, BH3 domain
  10. NM_138621.5NP_619527.1  bcl-2-like protein 11 isoform 1

    See identical proteins and their annotated locations for NP_619527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).
    Source sequence(s)
    AC096670, AI268146, BC033694
    Consensus CDS
    CCDS2089.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000376943.2, ENST00000393256.8
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:130166
    Bclx_interact; Bcl-x interacting, BH3 domain
  11. NM_138622.4NP_619528.1  bcl-2-like protein 11 isoform 2

    See identical proteins and their annotated locations for NP_619528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071195, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS74560.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481652.1, ENST00000621302.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  12. NM_138623.4NP_619529.1  bcl-2-like protein 11 isoform 3

    See identical proteins and their annotated locations for NP_619529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071196, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000478133.1, ENST00000620862.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:76103
    Bclx_interact; Bcl-x interacting, BH3 domain
  13. NM_138624.4NP_619530.1  bcl-2-like protein 11 isoform 4

    See identical proteins and their annotated locations for NP_619530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071197, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS56134.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000479714.1, ENST00000619294.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  14. NM_138625.4NP_619531.1  bcl-2-like protein 11 isoform 5

    See identical proteins and their annotated locations for NP_619531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071199, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    UniProtKB/TrEMBL
    A0A0C4DH20
    Related
    ENSP00000354879.6, ENST00000361493.10
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  15. NM_138626.4NP_619532.1  bcl-2-like protein 11 isoform 7

    See identical proteins and their annotated locations for NP_619532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB071198, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS74561.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000484360.1, ENST00000622612.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  16. NM_138627.4NP_619533.1  bcl-2-like protein 11 isoform 8

    See identical proteins and their annotated locations for NP_619533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB071200, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  17. NM_207002.3NP_996885.1  bcl-2-like protein 11 isoform 9

    See identical proteins and their annotated locations for NP_996885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA890664, AC096670, AK290377, AY352518
    Consensus CDS
    CCDS2092.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000338374.5, ENST00000337565.9
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  18. NM_207003.3NP_996886.1  bcl-2-like protein 11 isoform 10

    See identical proteins and their annotated locations for NP_996886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY305715
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4273
    Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    111120914..111168445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263556.3XP_005263613.1  bcl-2-like protein 11 isoform X8

    See identical proteins and their annotated locations for XP_005263613.1

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. XM_005263561.3XP_005263618.1  bcl-2-like protein 11 isoform X12

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:72103
    Bclx_interact; Bcl-x interacting, BH3 domain
  3. XM_017003102.1XP_016858591.1  bcl-2-like protein 11 isoform X13

  4. XM_005263551.3XP_005263608.1  bcl-2-like protein 11 isoform X2

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:226257
    Bclx_interact; Bcl-x interacting, BH3 domain
  5. XM_005263554.3XP_005263611.1  bcl-2-like protein 11 isoform X6

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  6. XM_005263553.3XP_005263610.1  bcl-2-like protein 11 isoform X5

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:166197
    Bclx_interact; Bcl-x interacting, BH3 domain
  7. XM_017003101.2XP_016858590.1  bcl-2-like protein 11 isoform X11

  8. XM_005263559.3XP_005263616.1  bcl-2-like protein 11 isoform X10

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:136167
    Bclx_interact; Bcl-x interacting, BH3 domain
  9. XM_005263550.4XP_005263607.1  bcl-2-like protein 11 isoform X1

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:226257
    Bclx_interact; Bcl-x interacting, BH3 domain
  10. XM_005263552.4XP_005263609.1  bcl-2-like protein 11 isoform X4

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:166197
    Bclx_interact; Bcl-x interacting, BH3 domain
  11. XM_005263555.4XP_005263612.1  bcl-2-like protein 11 isoform X7

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:136167
    Bclx_interact; Bcl-x interacting, BH3 domain
  12. XM_011510461.3XP_011508763.1  bcl-2-like protein 11 isoform X3

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  13. XM_011510464.3XP_011508766.1  bcl-2-like protein 11 isoform X9

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  14. XM_005263557.4XP_005263614.1  bcl-2-like protein 11 isoform X8

    See identical proteins and their annotated locations for XP_005263614.1

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain

RNA

  1. XR_244801.3 RNA Sequence

  2. XR_001738580.2 RNA Sequence

  3. XR_001738579.2 RNA Sequence

  4. XR_922829.3 RNA Sequence

  5. XR_922828.3 RNA Sequence

  6. XR_002958776.1 RNA Sequence

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