Format

Send to:

Choose Destination

BCL2L11 BCL2 like 11 [ Homo sapiens (human) ]

Gene ID: 10018, updated on 26-Aug-2018

Summary

Official Symbol
BCL2L11provided by HGNC
Official Full Name
BCL2 like 11provided by HGNC
Primary source
HGNC:HGNC:994
See related
Ensembl:ENSG00000153094 MIM:603827; Vega:OTTHUMG00000131256
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BAM; BIM; BOD
Summary
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013]
Expression
Ubiquitous expression in lymph node (RPKM 7.9), thyroid (RPKM 7.1) and 25 other tissues See more
Orthologs

Genomic context

See BCL2L11 in Genome Data Viewer
Location:
2q13
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (111120914..111168445)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (111878491..111926022)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene acyl-CoA oxidase like Neighboring gene ribosomal protein L5 pseudogene 9 Neighboring gene ACOXL antisense RNA 1 Neighboring gene MIR4435-2 host gene Neighboring gene uncharacterized LOC101927283 Neighboring gene ribosomal protein S14 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2018-06-21)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2018-06-21)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
A genome-wide association study identifies six susceptibility loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
NHGRI GWA Catalog
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.
NHGRI GWA Catalog
Genome-wide association study identifies multiple risk loci for chronic lymphocytic leukemia.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates BIM expression in Tat-infected Jurkat T cells PubMed
tat HIV-1 Tat acetylation at position K28 stimulates its activity to induce the translocation of Bim, a pro-apoptotic protein of the Bcl-2 family, from microtubules to mitochondria PubMed
tat HIV-1 Tat (amino acids 36-39) binds tubulin alpha/beta dimers and polymerized microtubules leading to the alteration of microtubule dynamics and activation of a mitochondria-dependent apoptotic pathway that is facilitated by the Bcl-2 relative Bim PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
    Activation of BH3-only proteins, organism-specific biosystemThe BH3-only members act as sentinels that selectively trigger apoptosis in response to developmental cues or stress-signals like DNA damages. Widely expressed mammalian BH3-only proteins are thought...
  • Activation of BIM and translocation to mitochondria, organism-specific biosystem (from REACTOME)
    Activation of BIM and translocation to mitochondria, organism-specific biosystemBIM acts as a sentinel to check the integrity of the cytoskeleton. It exists as two variant proteins: BIM-EL and BIM-L. In healthy cells, these two isoforms are sequestered to the dynein motor comple...
  • Apoptosis, organism-specific biosystem (from KEGG)
    Apoptosis, organism-specific biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, conserved biosystem (from KEGG)
    Apoptosis, conserved biosystemApoptosis is a genetically programmed process for the elimination of damaged or redundant cells by activation of caspases (aspartate-specific cysteine proteases). The onset of apoptosis is controlled...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis - multiple species, organism-specific biosystem (from KEGG)
    Apoptosis - multiple species, organism-specific biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis - multiple species, conserved biosystem (from KEGG)
    Apoptosis - multiple species, conserved biosystemApoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The ma...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem (from REACTOME)
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members, organism-specific biosystem
    BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
  • BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystem (from WikiPathways)
    BMP2-WNT4-FOXO1 Pathway in Human Primary Endometrial Stromal Cell Differentiation, organism-specific biosystemThis pathway is based on figure 6 from Li et al. BMP2 is activated by cAMP which promotes WNT4 expression in Human Primary Endometrial Stromal Cells (HPESCs) through SMAD1/5/8. WNT4 then induces FOXO...
  • Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystem (from WikiPathways)
    Brain-Derived Neurotrophic Factor (BDNF) signaling pathway, organism-specific biosystemBrain-derived neurotrophic factor (BDNF) is a neurotrophin essential for growth, differentiation, plasticity, and survival of neurons. BDNF is also required for processes such as energy metabolism, b...
  • Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystem (from REACTOME)
    Cell death signalling via NRAGE, NRIF and NADE, organism-specific biosystemp75NTR is a key regulator of neuronal apoptosis, both during development and after injury. Apoptosis is triggered by binding of either mature neurotrophin or proneurotrophin (proNGF, proBDNF). ProNG...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, organism-specific biosystem (from REACTOME)
    Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models, organism-specific biosystemPost-mitotic neurons do not have an active cell cycle. However, deregulation of Cyclin Dependent Kinase-5 (CDK5) activity in these neurons can aberrantly activate various components of cell cycle lea...
  • Disease, organism-specific biosystem (from REACTOME)
    Disease, organism-specific biosystemBiological processes are captured in Reactome by identifying the molecules (DNA, RNA, protein, small molecules) involved in them and describing the details of their interactions. From this molecular ...
  • Diseases of signal transduction, organism-specific biosystem (from REACTOME)
    Diseases of signal transduction, organism-specific biosystemSignaling processes are central to human physiology (e.g., Pires-da Silva & Sommer 2003), and their disruption by either germ-line and somatic mutation can lead to serious disease. Here, the molecula...
  • EGFR tyrosine kinase inhibitor resistance, organism-specific biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, organism-specific biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • EGFR tyrosine kinase inhibitor resistance, conserved biosystem (from KEGG)
    EGFR tyrosine kinase inhibitor resistance, conserved biosystemEGFR is a tyrosine kinase that participates in the regulation of cellular homeostasis. EGFR also serves as a stimulus for cancer growth. EGFR gene mutations and protein overexpression, both of which ...
  • ErbB Signaling Pathway, organism-specific biosystem (from WikiPathways)
    ErbB Signaling Pathway, organism-specific biosystemThe ErbB protein family or epidermal growth factor receptor (EGFR) family is a family of four structurally related receptor tyrosine kinases. Insufficient ErbB signaling in humans is associated with ...
  • FoxO family signaling, organism-specific biosystem (from Pathway Interaction Database)
    FoxO family signaling, organism-specific biosystem
    FoxO family signaling
  • FoxO signaling pathway, organism-specific biosystem (from KEGG)
    FoxO signaling pathway, organism-specific biosystemThe forkhead box O (FOXO) family of transcription factors regulates the expression of genes in cellular physiological events including apoptosis, cell-cycle control, glucose metabolism, oxidative str...
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
  • MicroRNAs in cancer, organism-specific biosystem (from KEGG)
    MicroRNAs in cancer, organism-specific biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • MicroRNAs in cancer, conserved biosystem (from KEGG)
    MicroRNAs in cancer, conserved biosystemMicroRNA (miRNA) is a cluster of small non-encoding RNA molecules of 21 - 23 nucleotides in length, which controls gene expression post-transcriptionally either via the degradation of target mRNAs or...
  • NRAGE signals death through JNK, organism-specific biosystem (from REACTOME)
    NRAGE signals death through JNK, organism-specific biosystemOnce bound by either NGF or proNGF, p75NTR interacts with NRAGE, thus leading to phosphorylation and activation of JUN Kinase (JNK). JNK controls apoptosis in two ways: it induces transcription of pr...
  • Neurodegenerative Diseases, organism-specific biosystem (from REACTOME)
    Neurodegenerative Diseases, organism-specific biosystemNeurodegenerative diseases manifest as the progressive dysfunction and loss of neurons, which is frequently accompanied by formation of misfolded protein deposits in the brain. Classification of neur...
  • Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), organism-specific biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Non-alcoholic fatty liver disease (NAFLD), conserved biosystem (from KEGG)
    Non-alcoholic fatty liver disease (NAFLD), conserved biosystemNon-alcoholic fatty liver disease (NAFLD) represents a spectrum ranging from simple steatosis to more severe steatohepatitis with hepatic inflammation and fibrosis, known as nonalcoholic steatohepati...
  • Oncogenic MAPK signaling, organism-specific biosystem (from REACTOME)
    Oncogenic MAPK signaling, organism-specific biosystemThe importance of the RAS/RAF/MAPK cascade in regulating cellular proliferation, differentiation and survival is highlighted by the fact that components of the pathway are mutated with high frequency...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced AP-1 survival signaling., organism-specific biosystemPhotodynamic therapy may induce an acute stress response mediated by mitogen-activated protein kinase kinase kinase 5 (MAP3K5), its downstream MAPKs that target c-Jun N-terminal kinase (JNK, MAPK8) a...
  • Photodynamic therapy-induced unfolded protein response, organism-specific biosystem (from WikiPathways)
    Photodynamic therapy-induced unfolded protein response, organism-specific biosystemPhotodynamic therapy may induce a proteotoxic stress response mediated by transcription factors heat shock factor 1 (HSF1), X-box binding protein 1 (XBP1), activating transcription factor (ATF) 6, an...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by BRAF and RAF fusions, organism-specific biosystem (from REACTOME)
    Signaling by BRAF and RAF fusions, organism-specific biosystemIn addition to the more prevalent point mutations, BRAF and RAF1 are also subject to activation as a result of translocation events that yield truncated or fusion products (Jones et al, 2008; Cin et ...
  • Signalling by NGF, organism-specific biosystem (from REACTOME)
    Signalling by NGF, organism-specific biosystemNeurotrophins (NGF, BDNF, NT-3, NT-4/5) play pivotal roles in survival, differentiation, and plasticity of neurons in the peripheral and central nervous system. They are produced, and secreted in mi...
  • p75 NTR receptor-mediated signalling, organism-specific biosystem (from REACTOME)
    p75 NTR receptor-mediated signalling, organism-specific biosystemBesides signalling through the tyrosine kinase receptors TRK A, B, and C, the mature neurotrophins NGF, BDNF, and NT3/4 signal through their common receptor p75NTR. NGF binding to p75NTR activates a ...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
dynein complex binding IEA
Inferred from Electronic Annotation
more info
 
microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
 
protein kinase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
B cell apoptotic process IEA
Inferred from Electronic Annotation
more info
 
B cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
T cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
apoptotic process TAS
Traceable Author Statement
more info
PubMed 
apoptotic process involved in embryonic digit morphogenesis IEA
Inferred from Electronic Annotation
more info
 
brain development IEA
Inferred from Electronic Annotation
more info
 
cell-matrix adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular process regulating host cell cycle in response to virus IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucocorticoid stimulus TAS
Traceable Author Statement
more info
PubMed 
developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
ear development IEA
Inferred from Electronic Annotation
more info
 
extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
intrinsic apoptotic signaling pathway in response to DNA damage IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
male gonad development IEA
Inferred from Electronic Annotation
more info
 
mammary gland development IEA
Inferred from Electronic Annotation
more info
 
myeloid cell homeostasis IEA
Inferred from Electronic Annotation
more info
 
odontogenesis of dentin-containing tooth IEA
Inferred from Electronic Annotation
more info
 
positive regulation of IRE1-mediated unfolded protein response TAS
Traceable Author Statement
more info
PubMed 
positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of apoptotic process by virus IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of intrinsic apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein homooligomerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of release of cytochrome c from mitochondria IMP
Inferred from Mutant Phenotype
more info
PubMed 
post-embryonic animal organ morphogenesis IEA
Inferred from Electronic Annotation
more info
 
protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
PubMed 
regulation of developmental pigmentation IEA
Inferred from Electronic Annotation
more info
 
regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
spleen development IEA
Inferred from Electronic Annotation
more info
 
thymocyte apoptotic process IEA
Inferred from Electronic Annotation
more info
 
thymus development IEA
Inferred from Electronic Annotation
more info
 
tube formation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Bcl-2 family protein complex IEA
Inferred from Electronic Annotation
more info
 
cytosol TAS
Traceable Author Statement
more info
 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
extrinsic component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
bcl-2-like protein 11
Names
BCL2-like 11 (apoptosis facilitator)
bcl-2 interacting mediator of cell death
bcl-2 interacting protein Bim
bcl-2-related ovarian death agonist

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029006.1 RefSeqGene

    Range
    5001..52532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_620

mRNA and Protein(s)

  1. NM_001204106.1NP_001191035.1  bcl-2-like protein 11 isoform 11

    See identical proteins and their annotated locations for NP_001191035.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11, also known as BimS) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting isoform (11) is shorter, compared to isoform 1.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY305714
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4273
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. NM_001204107.1NP_001191036.1  bcl-2-like protein 11 isoform 12

    See identical proteins and their annotated locations for NP_001191036.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) uses an alternate in-frame splice site in the 5' coding region, contains two alternate internal exons, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (12) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY423442
    Consensus CDS
    CCDS56132.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481423.1, ENST00000615946.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4673
    Bclx_interact; Bcl-x interacting, BH3 domain
  3. NM_001204108.1NP_001191037.1  bcl-2-like protein 11 isoform 13

    See identical proteins and their annotated locations for NP_001191037.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (13) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY423443
    Consensus CDS
    CCDS56135.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000482175.1, ENST00000622509.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  4. NM_001204109.1NP_001191038.1  bcl-2-like protein 11 isoform 14

    See identical proteins and their annotated locations for NP_001191038.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) lacks an internal exon, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (14) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY428962
    Consensus CDS
    CCDS56136.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481030.1, ENST00000610735.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  5. NM_001204110.1NP_001191039.1  bcl-2-like protein 11 isoform 15

    See identical proteins and their annotated locations for NP_001191039.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) uses an alternate in-frame splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (15) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849200
    Consensus CDS
    CCDS56133.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000391292.1, OTTHUMP00000204253, ENST00000452231.5, OTTHUMT00000314295
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4673
    Bclx_interact; Bcl-x interacting, BH3 domain
  6. NM_001204111.1NP_001191040.1  bcl-2-like protein 11 isoform 16

    See identical proteins and their annotated locations for NP_001191040.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) lacks an in-frame segment in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (16) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849201
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  7. NM_001204112.1NP_001191041.1  bcl-2-like protein 11 isoform 17

    See identical proteins and their annotated locations for NP_001191041.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) lacks an alternate in-frame segment in the 5' coding region, lacks an internal exon, and contains an alternate internal exon, compared to variant 1. The resulting isoform (17) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, DQ849202
    Consensus CDS
    CCDS56131.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000393781.1, OTTHUMP00000204250, ENST00000415458.5, OTTHUMT00000314292
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  8. NM_001204113.1NP_001191042.1  bcl-2-like protein 11 isoform 18

    See identical proteins and their annotated locations for NP_001191042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) lacks an alternate in-frame segment and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (18) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC096670, AK290377, AW629314
    Consensus CDS
    CCDS74559.1
    UniProtKB/Swiss-Prot
    O43521
    UniProtKB/TrEMBL
    A0A0A0MRE7
    Related
    ENSP00000350398.3, ENST00000357757.6
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  9. NM_006538.4NP_006529.1  bcl-2-like protein 11 isoform 6

    See identical proteins and their annotated locations for NP_006529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6, also known as BimL) lacks an in-frame segment in the 5' coding coding region, compared to variant 1. The resulting isoform (6) is shorter, compared to isoform 1.
    Source sequence(s)
    AC096670, AF032458, AI268146, AK290377, BC033694
    Consensus CDS
    CCDS42731.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000309226.8, OTTHUMP00000204243, ENST00000308659.12, OTTHUMT00000331936
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:72103
    Bclx_interact; Bcl-x interacting, BH3 domain
  10. NM_138621.4NP_619527.1  bcl-2-like protein 11 isoform 1

    See identical proteins and their annotated locations for NP_619527.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as BimEL) encodes the longest isoform (1).
    Source sequence(s)
    AC096670, AI268146, BC033694
    Consensus CDS
    CCDS2089.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000376943.2, OTTHUMP00000161927, ENST00000393256.7, OTTHUMT00000254022
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  11. NM_138622.3NP_619528.1  bcl-2-like protein 11 isoform 2

    See identical proteins and their annotated locations for NP_619528.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as Bim-alpha1) contains an alternate internal exon and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (2) contains a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071195, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS74560.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000481652.1, ENST00000621302.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  12. NM_138623.3NP_619529.1  bcl-2-like protein 11 isoform 3

    See identical proteins and their annotated locations for NP_619529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, also known as Bim-ACD and Bim-alpha2) lacks a 5' segment, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071196, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000478133.1, ENST00000620862.4
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:76103
    Bclx_interact; Bcl-x interacting, BH3 domain
  13. NM_138624.3NP_619530.1  bcl-2-like protein 11 isoform 4

    See identical proteins and their annotated locations for NP_619530.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4, also known as Bim-beta1) contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (4) has a shorter and distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071197, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS56134.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000479714.1, ENST00000619294.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  14. NM_138625.3NP_619531.1  bcl-2-like protein 11 isoform 5

    See identical proteins and their annotated locations for NP_619531.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5, also known as Bim-beta3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (5) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AB071199, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    UniProtKB/TrEMBL
    A0A0C4DH20
    Related
    ENSP00000354879.6, OTTHUMP00000204246, ENST00000361493.10, OTTHUMT00000331939
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  15. NM_138626.3NP_619532.1  bcl-2-like protein 11 isoform 7

    See identical proteins and their annotated locations for NP_619532.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7, also known as Bim-ABC and Bim-beta2) lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (7) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB071198, AC096670, AI268146, AK290377
    Consensus CDS
    CCDS74561.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000484360.1, ENST00000622612.4
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  16. NM_138627.3NP_619533.1  bcl-2-like protein 11 isoform 8

    See identical proteins and their annotated locations for NP_619533.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8, also known as Bim-A and Bim-beta4) uses an alternate splice site in the 5' coding region, and lacks an exon in the 3' coding region which results in a frameshift, compared to variant 1. The resulting isoform (8) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AB071200, AC096670, AI268146, AK290377
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  17. NM_207002.3NP_996885.1  bcl-2-like protein 11 isoform 9

    See identical proteins and their annotated locations for NP_996885.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9, also known as Bim-gamma) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. The resulting isoform (9) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AA890664, AC096670, AK290377, AY352518
    Consensus CDS
    CCDS2092.1
    UniProtKB/Swiss-Prot
    O43521
    Related
    ENSP00000338374.5, ENST00000337565.9
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  18. NM_207003.2NP_996886.1  bcl-2-like protein 11 isoform 10

    See identical proteins and their annotated locations for NP_996886.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10, also known as Bim-alpha3) uses an alternate splice site in the 5' coding region, contains an alternate internal exon, and differs in the 3' coding region and UTR, compared to variant 1. The resulting isoform (10) is shorter and has a distinct C-terminus, compared to isoform 1. This record was created to support clinical studies, but the encoded isoform currently lacks experimental evidence.
    Source sequence(s)
    AC096670, AI268146, AK290377, AY305715
    UniProtKB/Swiss-Prot
    O43521
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4273
    Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    111120914..111168445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263556.3XP_005263613.1  bcl-2-like protein 11 isoform X8

    See identical proteins and their annotated locations for XP_005263613.1

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. XM_005263561.3XP_005263618.1  bcl-2-like protein 11 isoform X12

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:72103
    Bclx_interact; Bcl-x interacting, BH3 domain
  3. XM_017003102.1XP_016858591.1  bcl-2-like protein 11 isoform X13

  4. XM_005263551.3XP_005263608.1  bcl-2-like protein 11 isoform X2

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:226257
    Bclx_interact; Bcl-x interacting, BH3 domain
  5. XM_005263554.3XP_005263611.1  bcl-2-like protein 11 isoform X6

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  6. XM_005263553.3XP_005263610.1  bcl-2-like protein 11 isoform X5

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:166197
    Bclx_interact; Bcl-x interacting, BH3 domain
  7. XM_017003101.2XP_016858590.1  bcl-2-like protein 11 isoform X11

  8. XM_005263559.3XP_005263616.1  bcl-2-like protein 11 isoform X10

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:136167
    Bclx_interact; Bcl-x interacting, BH3 domain
  9. XM_005263550.4XP_005263607.1  bcl-2-like protein 11 isoform X1

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:226257
    Bclx_interact; Bcl-x interacting, BH3 domain
  10. XM_005263552.4XP_005263609.1  bcl-2-like protein 11 isoform X4

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:166197
    Bclx_interact; Bcl-x interacting, BH3 domain
  11. XM_005263555.4XP_005263612.1  bcl-2-like protein 11 isoform X7

    Conserved Domains (2) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:136167
    Bclx_interact; Bcl-x interacting, BH3 domain
  12. XM_011510461.3XP_011508763.1  bcl-2-like protein 11 isoform X3

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  13. XM_011510464.3XP_011508766.1  bcl-2-like protein 11 isoform X9

    Conserved Domains (1) summary
    pfam06773
    Location:98134
    Bim_N; Bim protein N-terminus
  14. XM_005263557.4XP_005263614.1  bcl-2-like protein 11 isoform X8

    See identical proteins and their annotated locations for XP_005263614.1

    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:132163
    Bclx_interact; Bcl-x interacting, BH3 domain

RNA

  1. XR_244801.3 RNA Sequence

  2. XR_001738580.2 RNA Sequence

  3. XR_001738579.2 RNA Sequence

  4. XR_922829.3 RNA Sequence

  5. XR_922828.3 RNA Sequence

  6. XR_002958776.1 RNA Sequence

Support Center