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Bcl2l11 BCL2 like 11 [ Mus musculus (house mouse) ]

Gene ID: 12125, updated on 21-Apr-2024

Summary

Official Symbol
Bcl2l11provided by MGI
Official Full Name
BCL2 like 11provided by MGI
Primary source
MGI:MGI:1197519
See related
Ensembl:ENSMUSG00000027381 AllianceGenome:MGI:1197519
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bim; Bod; bcl2-L-11; 1500006F24Rik
Summary
Enables dynein complex binding activity; microtubule binding activity; and protein kinase binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within several processes, including animal organ development; apoptotic signaling pathway; and lymphocyte homeostasis. Located in mitochondrion. Is extrinsic component of membrane. Part of Bcl-2 family protein complex. Is expressed in brain; hair outer root sheath; metanephros; spleen; and trunk unsegmented mesenchyme. Orthologous to human BCL2L11 (BCL2 like 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 7.8), lung adult (RPKM 4.3) and 28 other tissues See more
Orthologs
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Genomic context

Location:
2 F1; 2 62.23 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (127967958..128004467)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128126038..128162547)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E415 Neighboring gene STARR-seq mESC enhancer starr_05631 Neighboring gene BUB1, mitotic checkpoint serine/threonine kinase Neighboring gene acyl-Coenzyme A oxidase-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127753660-127754051 Neighboring gene STARR-positive B cell enhancer ABC_E7858 Neighboring gene STARR-positive B cell enhancer ABC_E9204 Neighboring gene STARR-positive B cell enhancer ABC_E10140 Neighboring gene STARR-seq mESC enhancer starr_05633 Neighboring gene STARR-positive B cell enhancer ABC_E10141 Neighboring gene STARR-positive B cell enhancer ABC_E4497 Neighboring gene STARR-positive B cell enhancer ABC_E9532 Neighboring gene STARR-positive B cell enhancer mm9_chr2:127953069-127953369 Neighboring gene predicted gene, 23101 Neighboring gene STARR-seq mESC enhancer starr_05636 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127978569-127978830 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:127981992-127982193 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:128029897-128030080 Neighboring gene predicted gene 14009 Neighboring gene STARR-seq mESC enhancer starr_05639 Neighboring gene STARR-seq mESC enhancer starr_05640 Neighboring gene STARR-seq mESC enhancer starr_05641 Neighboring gene STARR-positive B cell enhancer ABC_E5979 Neighboring gene STARR-seq mESC enhancer starr_05642 Neighboring gene STARR-positive B cell enhancer ABC_E7860 Neighboring gene myeloid RNA regulator of BCL2L11 induced cell death Neighboring gene STARR-positive B cell enhancer ABC_E11707 Neighboring gene STARR-positive B cell enhancer ABC_E10142 Neighboring gene STARR-positive B cell enhancer ABC_E11160 Neighboring gene STARR-positive B cell enhancer mm9_chr2:128221938-128222238 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:128238239-128238556 Neighboring gene predicted gene 14010

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables microtubule binding IDA
Inferred from Direct Assay
more info
PubMed 
contributes_to microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within B cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within T cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of cysteine-type endopeptidase activity involved in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within apoptotic process involved in embryonic digit morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within ear development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within in utero embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway in response to DNA damage ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within kidney development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within leukocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within leukocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within lymphocyte homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within mammary gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiosis I IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within myeloid cell homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of T cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy in response to ER overload ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of lymphocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of mitochondrial membrane permeability involved in apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of release of cytochrome c from mitochondria ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of developmental pigmentation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of organ growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to endoplasmic reticulum stress ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within spermatogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spleen development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within symbiont-mediated activation of host apoptosis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within thymocyte apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within thymus development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within tube formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of BIM-BCL-2 complex ISO
Inferred from Sequence Orthology
more info
 
part_of BIM-BCL-xl complex ISO
Inferred from Sequence Orthology
more info
 
part_of Bcl-2 family protein complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of Bcl-2 family protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
bcl-2-like protein 11
Names
BCL2-like 11 (apoptosis facilitator)
Bcl2 interacting mediator of cell death
bcl2-interacting mediator of cell death

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001284410.3NP_001271339.2  bcl-2-like protein 11 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL805950
    UniProtKB/TrEMBL
    Q6PEB3
  2. NM_001291016.1NP_001277945.1  bcl-2-like protein 11 isoform 4

    See identical proteins and their annotated locations for NP_001277945.1

    Status: VALIDATED

    Source sequence(s)
    AK037885, AK162975
    Consensus CDS
    CCDS71141.1
    UniProtKB/TrEMBL
    Q6PEB3
    Related
    ENSMUSP00000087062.6, ENSMUST00000089634.12
    Conserved Domains (1) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
  3. NM_001406057.1NP_001392986.1  bcl-2-like protein 11 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL805950
  4. NM_001406058.1NP_001392987.1  bcl-2-like protein 11 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL805950
    UniProtKB/TrEMBL
    Q3U7X3
  5. NM_001406059.1NP_001392988.1  bcl-2-like protein 11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL805950
  6. NM_001406060.1NP_001392989.1  bcl-2-like protein 11 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL805950
  7. NM_001406061.1NP_001392990.1  bcl-2-like protein 11 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL805950
  8. NM_009754.3NP_033884.1  bcl-2-like protein 11 isoform 3

    See identical proteins and their annotated locations for NP_033884.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1, resulting in an isoform (3) that is shorter than isoform 1.
    Source sequence(s)
    AA881651, AF032461, AK037885, AK082613, BE136124, CA321725, CB521709
    Consensus CDS
    CCDS16712.1
    UniProtKB/TrEMBL
    Q3U7X3
    Related
    ENSMUSP00000099500.2, ENSMUST00000103211.8
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:4276
    Bclx_interact; Bcl-x interacting, BH3 domain
  9. NM_207680.2NP_997563.1  bcl-2-like protein 11 isoform 1

    See identical proteins and their annotated locations for NP_997563.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA881651, AK037885, AK082613, BE136124, CA321725, CB521709
    Consensus CDS
    CCDS16713.1
    UniProtKB/Swiss-Prot
    A2ALQ6, O54918, O54919, O54920
    UniProtKB/TrEMBL
    Q542N5
    Related
    ENSMUSP00000105970.3, ENSMUST00000110341.9
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:128164
    Bclx_interact; Bcl-x interacting, BH3 domain
  10. NM_207681.2NP_997564.1  bcl-2-like protein 11 isoform 2

    See identical proteins and their annotated locations for NP_997564.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame segment in the central coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.
    Source sequence(s)
    AA881651, AK037885, AK050192, AK082613, BE136124, CA321725, CB521709
    Consensus CDS
    CCDS16714.1
    UniProtKB/Swiss-Prot
    O54918
    UniProtKB/TrEMBL
    Q542N5
    Related
    ENSMUSP00000099499.2, ENSMUST00000103210.2
    Conserved Domains (2) summary
    pfam06773
    Location:440
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:72106
    Bclx_interact; Bcl-x interacting, BH3 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    127967958..128004467
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006498614.4XP_006498677.1  bcl-2-like protein 11 isoform X1

    Conserved Domains (2) summary
    pfam06773
    Location:78114
    Bim_N; Bim protein N-terminus
    pfam08945
    Location:202236
    Bclx_interact; Bcl-x interacting, BH3 domain
  2. XM_006498615.4XP_006498678.1  bcl-2-like protein 11 isoform X2

    Conserved Domains (1) summary
    pfam06773
    Location:78114
    Bim_N; Bim protein N-terminus