PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [Pongo abelii (Sumatran orangutan)] - Gene

Summary

Gene symbol: PRKAA1
Gene description: protein kinase AMP-activated catalytic subunit alpha 1
Locus tag: CR201_G0011967
See related: Ensembl:ENSPPYG00000015421
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Pongo abelii
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2)	4	NC_071989.2 (41018526..41060091, complement)
RS_2023_04	previous assembly	NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1)	5	NC_071990.1 (41018546..41060111, complement)

Chromosome 4 - NC_071989.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

STS-N23112 (e-PCR)
- UniSTS:79672

NM_006251 (e-PCR)
- UniSTS:497561

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 5'-AMP-activated protein kinase catalytic subunit alpha-1

Names: ACACA kinase; AMPK subunit alpha-1; HMGCR kinase; acetyl-CoA carboxylase kinase; hydroxymethylglutaryl-CoA reductase kinase; protein kinase, AMP-activated, alpha 1 catalytic subunit; tau-protein kinase PRKAA1

NP_001127249.1

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

XP_009238944.2

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

XP_024102548.2

EC 2.7.11.1

EC 2.7.11.26

EC 2.7.11.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001133777.1 → NP_001127249.1 5'-AMP-activated protein kinase catalytic subunit alpha-1

See identical proteins and their annotated locations for NP_001127249.1

Status: PROVISIONAL

Source sequence(s)

CR857935

UniProtKB/Swiss-Prot

Q5RDH5

Related

ENSPPYP00000017227.3, ENSPPYT00000017927.3

Conserved Domains (4) summary

cd12199
Location:395 → 548

AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit

smart00220
Location:18 → 270

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14403
Location:287 → 351

UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)

cd14079
Location:15 → 270

STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Genomic

NC_071989.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

Range

41018526..41060091 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009240669.3 → XP_009238944.2 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

UniProtKB/TrEMBL

A0A2J8WBH3, H2PFE9
XM_024246780.2 → XP_024102548.2 5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2