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PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 [ Homo sapiens (human) ]

Gene ID: 5562, updated on 10-Jan-2021

Summary

Official Symbol
PRKAA1provided by HGNC
Official Full Name
protein kinase AMP-activated catalytic subunit alpha 1provided by HGNC
Primary source
HGNC:HGNC:9376
See related
Ensembl:ENSG00000132356 MIM:602739
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AMPK; AMPKa1
Summary
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in gall bladder (RPKM 18.4), thyroid (RPKM 16.3) and 25 other tissues See more
Orthologs
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Genomic context

See PRKAA1 in Genome Data Viewer
Location:
5p13.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (40759379..40798195, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40759481..40798297, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374737 Neighboring gene prostaglandin E receptor 4 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene CRISPRi-validated cis-regulatory element chr5.1161 Neighboring gene small nucleolar RNA, C/D box 72 Neighboring gene ribosomal protein L37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of protein kinase, AMP-activated, alpha 1 catalytic subunit (PRKAA1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat-induced LTR transactivation is reversed by tanshinone II A through the AMPK-Nampt pathway PubMed
tat MiR-217 regulates HIV-1 Tat-induced activation of NF-kappaB and inactivation of AMPK in MAGI cells PubMed
tat Knockdown of SIRT1 by its inhibitor or siRNA results in Tat-mediated reduction of phosphorylation of AMP-activated protein kinase (AMPK) and downstream acetyl-CoA carboxylase (ACC) PubMed
tat Knockdown of PRKAA1 by siRNAs inhibits HIV LTR-beta-gal activation in the Tat transactivation assay PubMed
Vif vif Protein kinase A (PKA) binds and phosphorylates A3G at Thr32 in vitro and in vivo. This phosphorylation event reduces the binding of A3G to Vif and its subsequent ubiquitination and degradation PubMed
Vpr vpr HIV-1 Vpr directly interacts with PKA and is phosphorylated at position Ser79 by PKA. PKA activity is necessary for virion-delivered Vpr cell cycle arrest PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC33776, MGC57364

Gene Ontology Provided by GOA

Function Evidence Code Pubs
AMP-activated protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
AMP-activated protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
AMP-activated protein kinase activity TAS
Traceable Author Statement
more info
PubMed 
ATP binding IEA
Inferred from Electronic Annotation
more info
 
[acetyl-CoA carboxylase] kinase activity IEA
Inferred from Electronic Annotation
more info
 
[hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity IEA
Inferred from Electronic Annotation
more info
 
cAMP-dependent protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
histone serine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
tau protein binding NAS
Non-traceable Author Statement
more info
PubMed 
tau-protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
CAMKK-AMPK signaling cascade IC
Inferred by Curator
more info
PubMed 
CAMKK-AMPK signaling cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
CAMKK-AMPK signaling cascade TAS
Traceable Author Statement
more info
PubMed 
Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
 
activation of MAPK activity NAS
Non-traceable Author Statement
more info
PubMed 
bile acid and bile salt transport IEA
Inferred from Electronic Annotation
more info
 
bile acid signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest TAS
Traceable Author Statement
more info
 
cellular response to calcium ion ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
cellular response to ethanol IEA
Inferred from Electronic Annotation
more info
 
cellular response to glucose starvation ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to hydrogen peroxide IEA
Inferred from Electronic Annotation
more info
 
cellular response to hypoxia IEA
Inferred from Electronic Annotation
more info
 
cellular response to nutrient levels ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
cellular response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to prostaglandin E stimulus IEA
Inferred from Electronic Annotation
more info
 
cholesterol biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
cold acclimation IEA
Inferred from Electronic Annotation
more info
 
energy homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
energy homeostasis TAS
Traceable Author Statement
more info
PubMed 
fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
fatty acid oxidation IEA
Inferred from Electronic Annotation
more info
 
glucose homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
glucose metabolic process IEA
Inferred from Electronic Annotation
more info
 
histone-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
macroautophagy TAS
Traceable Author Statement
more info
 
motor behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of gene expression ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of glucosylceramide biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of insulin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
negative regulation of lipid catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron cellular homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of autophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of autophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cellular protein localization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cholesterol biosynthetic process NAS
Non-traceable Author Statement
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glycolytic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of mitochondrial transcription IEA
Inferred from Electronic Annotation
more info
 
positive regulation of peptidyl-lysine acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein targeting to mitochondrion IEA
Inferred from Electronic Annotation
more info
 
positive regulation of skeletal muscle tissue development IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of bile acid secretion IEA
Inferred from Electronic Annotation
more info
 
regulation of circadian rhythm ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of macroautophagy TAS
Traceable Author Statement
more info
 
regulation of microtubule cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of peptidyl-serine phosphorylation IEA
Inferred from Electronic Annotation
more info
 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
regulation of stress granule assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
 
response to 17alpha-ethynylestradiol IEA
Inferred from Electronic Annotation
more info
 
response to UV IEA
Inferred from Electronic Annotation
more info
 
response to activity IEA
Inferred from Electronic Annotation
more info
 
response to caffeine IEA
Inferred from Electronic Annotation
more info
 
response to camptothecin IEA
Inferred from Electronic Annotation
more info
 
response to gamma radiation ISS
Inferred from Sequence or Structural Similarity
more info
 
response to hypoxia NAS
Non-traceable Author Statement
more info
PubMed 
rhythmic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
axon ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleotide-activated protein kinase complex ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleotide-activated protein kinase complex TAS
Traceable Author Statement
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
5'-AMP-activated protein kinase catalytic subunit alpha-1
Names
5'-AMP-activated protein kinase, catalytic alpha-1 chain
ACACA kinase
AMP -activate kinase alpha 1 subunit
AMP-activated protein kinase, catalytic, alpha-1
AMPK alpha 1
AMPK subunit alpha-1
HMGCR kinase
acetyl-CoA carboxylase kinase
hydroxymethylglutaryl-CoA reductase kinase
protein kinase, AMP-activated, alpha 1 catalytic subunit
tau-protein kinase PRKAA1
NP_001341957.1
NP_001341958.1
NP_001341963.1
NP_001341964.1
NP_001341965.1
NP_001341966.1
NP_006242.5
NP_996790.3
XP_016865113.1
XP_016865114.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355028.2NP_001341957.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC008810
    Conserved Domains (3) summary
    cd12199
    Location:378531
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:270334
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:17253
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
  2. NM_001355029.2NP_001341958.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC008810
    Conserved Domains (3) summary
    cd12199
    Location:260413
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:152216
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:1135
    PKc_like; Protein Kinases, catalytic domain
  3. NM_001355034.1NP_001341963.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC008810, BC012622
    Related
    ENSP00000296800.4, ENST00000296800.4
    Conserved Domains (1) summary
    cl21453
    Location:24199
    PKc_like; Protein Kinases, catalytic domain
  4. NM_001355035.2NP_001341964.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform 6.
    Source sequence(s)
    AC008810
    Conserved Domains (3) summary
    cd12199
    Location:146299
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:38102
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:121
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001355036.2NP_001341965.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform 6.
    Source sequence(s)
    AC008810
    Conserved Domains (3) summary
    cd12199
    Location:146299
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:38102
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:121
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001355037.2NP_001341966.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform 6.
    Source sequence(s)
    AC008810
    Conserved Domains (3) summary
    cd12199
    Location:146299
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:38102
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cl21453
    Location:121
    PKc_like; Protein Kinases, catalytic domain
  7. NM_006251.5NP_006242.5  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 1

    See identical proteins and their annotated locations for NP_006242.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an in-frame coding exon compared to variant 2. The resulting isoform (1) lacks an internal segment, as compared to isoform 2.
    Source sequence(s)
    AC008810, BC048980, DB236105
    Consensus CDS
    CCDS3932.2
    UniProtKB/Swiss-Prot
    Q13131
    Related
    ENSP00000380317.2, ENST00000397128.6
    Conserved Domains (3) summary
    cd12199
    Location:404557
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:296360
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:24279
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
  8. NM_206907.3NP_996790.3  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform 2

    See identical proteins and their annotated locations for NP_996790.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) encodes the longest isoform (2).
    Source sequence(s)
    AC008810, BC048980, DB236105
    Consensus CDS
    CCDS3933.2
    UniProtKB/Swiss-Prot
    Q13131
    Related
    ENSP00000346148.3, ENST00000354209.7
    Conserved Domains (3) summary
    cd12199
    Location:419572
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:311375
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:24294
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    40759379..40798195 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017009625.2XP_016865114.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X2

    Conserved Domains (3) summary
    cd12199
    Location:378531
    AMPKA1_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha 1 catalytic subunit
    cd14403
    Location:270334
    UBA_AID_AAPK1; UBA-like autoinhibitory domain (AID) found in vertebrate 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPKalpha-1)
    cd14079
    Location:17253
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
  2. XM_017009624.1XP_016865113.1  5'-AMP-activated protein kinase catalytic subunit alpha-1 isoform X1

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