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TSTD1 thiosulfate sulfurtransferase like domain containing 1 [ Homo sapiens (human) ]

Gene ID: 100131187, updated on 9-Jun-2025
Official Symbol
TSTD1provided by HGNC
Official Full Name
thiosulfate sulfurtransferase like domain containing 1provided by HGNC
Primary source
HGNC:HGNC:35410
See related
Ensembl:ENSG00000215845 MIM:616041; AllianceGenome:HGNC:35410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT; TST
Summary
Predicted to enable thiosulfate-thiol sulfurtransferase activity. Predicted to be involved in sulfide oxidation, using sulfide:quinone oxidoreductase. Located in cytoplasmic ribonucleoprotein granule and cytosol. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Ubiquitous expression in prostate (RPKM 33.0), kidney (RPKM 26.4) and 25 other tissues See more
Orthologs
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See TSTD1 in Genome Data Viewer
Location:
1q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161037631..161038964, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (160175138..160176471, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161007421..161008754, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene F11 receptor Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160975781-160976290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976291-160976800 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:160976801-160977309 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1965 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1966 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:160985695-160986292 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1967 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1969 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:160991075-160991672 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161002153-161003089 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161004943-161005449 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:161005450-161005955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1970 Neighboring gene GLR5 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1972 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:161015335-161016534 Neighboring gene upstream transcription factor 1 Neighboring gene Rho GTPase activating protein 30 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:161038974-161039520

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables thiosulfate-thiol sulfurtransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables thiosulfate-thiol sulfurtransferase activity TAS
Traceable Author Statement
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
thiosulfate:glutathione sulfurtransferase
Names
putative thiosulfate sulfurtransferase KAT
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
NP_001106676.1
NP_001106677.1
NP_001106678.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113205.2NP_001106676.1  thiosulfate:glutathione sulfurtransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frameshift and premature stop codon, compared to variant 1. The encoded protein (isoform 3) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AV688621, BC001699
    Consensus CDS
    CCDS44258.1
    UniProtKB/Swiss-Prot
    Q8NFU3
    Related
    ENSP00000325518.10, ENST00000318289.14
    Conserved Domains (1) summary
    cl00125
    Location:7101
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  2. NM_001113206.2NP_001106677.1  thiosulfate:glutathione sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001106677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, that results a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AV688621, CD675389
    Consensus CDS
    CCDS44257.1
    UniProtKB/TrEMBL
    R4GNF9
    Related
    ENSP00000357003.1, ENST00000368024.5
    Conserved Domains (1) summary
    cl00125
    Location:471
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  3. NM_001113207.2NP_001106678.1  thiosulfate:glutathione sulfurtransferase isoform 1

    See identical proteins and their annotated locations for NP_001106678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    CD675389
    Consensus CDS
    CCDS53400.1
    UniProtKB/Swiss-Prot
    Q5SY48, Q5SY49, Q5SY50, Q5SY51, Q8NFU2, Q8NFU3, Q9BV22
    Related
    ENSP00000388293.2, ENST00000423014.3
    Conserved Domains (1) summary
    cl00125
    Location:7112
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    161037631..161038964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    160175138..160176471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)