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TSTD1 thiosulfate sulfurtransferase like domain containing 1 [ Homo sapiens (human) ]

Gene ID: 100131187, updated on 25-Nov-2021

Summary

Official Symbol
TSTD1provided by HGNC
Official Full Name
thiosulfate sulfurtransferase like domain containing 1provided by HGNC
Primary source
HGNC:HGNC:35410
See related
Ensembl:ENSG00000215845 MIM:616041
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAT; TST
Expression
Ubiquitous expression in prostate (RPKM 33.0), kidney (RPKM 26.4) and 25 other tissues See more
Orthologs
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Genomic context

See TSTD1 in Genome Data Viewer
Location:
1q23.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (161037631..161038964, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161007421..161008754, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 578 Neighboring gene F11 receptor Neighboring gene upstream transcription factor 1 Neighboring gene Rho GTPase activating protein 30

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables thiosulfate-thiol sulfurtransferase activity TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic ribonucleoprotein granule IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thiosulfate:glutathione sulfurtransferase
Names
putative thiosulfate sulfurtransferase KAT
thiosulfate sulfurtransferase (rhodanese)-like domain containing 1
thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 1
NP_001106676.1
NP_001106677.1
NP_001106678.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001113205.2NP_001106676.1  thiosulfate:glutathione sulfurtransferase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 3' coding region that results in a frameshift and premature stop codon, compared to variant 1. The encoded protein (isoform 3) has a shorter, distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AV688621, BC001699
    Consensus CDS
    CCDS44258.1
    UniProtKB/Swiss-Prot
    Q8NFU3
    Related
    ENSP00000325518.10, ENST00000318289.14
    Conserved Domains (1) summary
    cl00125
    Location:7101
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  2. NM_001113206.2NP_001106677.1  thiosulfate:glutathione sulfurtransferase isoform 2

    See identical proteins and their annotated locations for NP_001106677.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1, that results a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AV688621, CD675389
    Consensus CDS
    CCDS44257.1
    UniProtKB/Swiss-Prot
    Q8NFU3
    Related
    ENSP00000357003.1, ENST00000368024.5
    Conserved Domains (1) summary
    cl00125
    Location:471
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...
  3. NM_001113207.2NP_001106678.1  thiosulfate:glutathione sulfurtransferase isoform 1

    See identical proteins and their annotated locations for NP_001106678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    CD675389
    Consensus CDS
    CCDS53400.1
    UniProtKB/Swiss-Prot
    Q8NFU3
    Related
    ENSP00000388293.2, ENST00000423014.3
    Conserved Domains (1) summary
    cl00125
    Location:7112
    RHOD; Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    161037631..161038964 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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