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F11R F11 receptor [ Homo sapiens (human) ]

Gene ID: 50848, updated on 13-Mar-2020

Summary

Official Symbol
F11Rprovided by HGNC
Official Full Name
F11 receptorprovided by HGNC
Primary source
HGNC:HGNC:14685
See related
Ensembl:ENSG00000158769 MIM:605721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
JAM; KAT; JAM1; JAMA; JCAM; CD321; PAM-1
Summary
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is an important regulator of tight junction assembly in epithelia. In addition, the encoded protein can act as (1) a receptor for reovirus, (2) a ligand for the integrin LFA1, involved in leukocyte transmigration, and (3) a platelet receptor. Multiple 5' alternatively spliced variants, encoding the same protein, have been identified but their biological validity has not been established. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lung (RPKM 46.3), small intestine (RPKM 31.8) and 24 other tissues See more
Orthologs

Genomic context

See F11R in Genome Data Viewer
Location:
1q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (160995211..161021152, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (160965001..160991133, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene spermine synthase pseudogene Neighboring gene uncharacterized LOC101928372 Neighboring gene intelectin 2 Neighboring gene thiosulfate sulfurtransferase like domain containing 1 Neighboring gene upstream transcription factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of F11R PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Cannabinoid inhibits HIV-1 gp120-induced tight junction protein down-regulation of ZO-1, claudin-5, and JAM-1 in human brain micro vascular endothelial cells (HBMEC) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TSTD1

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
PDZ domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
cadherin binding HDA PubMed 
integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
virus receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
bicellular tight junction assembly TAS
Traceable Author Statement
more info
 
cell-cell adhesion IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to mechanical stimulus IDA
Inferred from Direct Assay
more info
PubMed 
establishment of endothelial intestinal barrier IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
establishment of endothelial intestinal barrier IGI
Inferred from Genetic Interaction
more info
PubMed 
establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
extracellular matrix organization TAS
Traceable Author Statement
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
intestinal absorption IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intestinal absorption IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
memory T cell extravasation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of stress fiber assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Rho protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of blood pressure IEA
Inferred from Electronic Annotation
more info
 
positive regulation of establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of platelet aggregation IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to bicellular tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of bicellular tight junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of cell shape IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytokine production IEA
Inferred from Electronic Annotation
more info
 
regulation of cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of membrane permeability IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of membrane permeability IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to radiation IEA
Inferred from Electronic Annotation
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
viral entry into host cell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction TAS
Traceable Author Statement
more info
 
cell-cell junction TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 
slit diaphragm IEA
Inferred from Electronic Annotation
more info
 
tight junction IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
junctional adhesion molecule A
Names
junctional adhesion molecule 1
platelet F11 receptor
platelet adhesion molecule 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348091.2NP_001335020.1  junctional adhesion molecule A isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AK304412, AL591806
    Consensus CDS
    CCDS86026.1
    UniProtKB/Swiss-Prot
    Q9Y624
    Related
    ENSP00000440812.1, ENST00000537746.1
    Conserved Domains (1) summary
    pfam13927
    Location:78167
    Ig_3; Immunoglobulin domain
  2. NM_016946.6NP_058642.1  junctional adhesion molecule A isoform 1 precursor

    See identical proteins and their annotated locations for NP_058642.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF172398, AL591806, DA907460
    Consensus CDS
    CCDS1213.1
    UniProtKB/Swiss-Prot
    Q9Y624
    UniProtKB/TrEMBL
    Q6FIB4
    Related
    ENSP00000357005.5, ENST00000368026.11
    Conserved Domains (2) summary
    smart00410
    Location:36125
    IG_like; Immunoglobulin like
    pfam13927
    Location:134216
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    160995211..161021152 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_144501.1: Suppressed sequence

    Description
    NM_144501.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NM_144502.1: Suppressed sequence

    Description
    NM_144502.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
  3. NM_144503.1: Suppressed sequence

    Description
    NM_144503.1: This RefSeq was permanently suppressed because it is now thought that it represents a rare read-through transcript.
  4. NM_144504.1: Suppressed sequence

    Description
    NM_144504.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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