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Am J Physiol Cell Physiol. 2016 May 15;310(10):C836-40. doi: 10.1152/ajpcell.00053.2016. Epub 2016 Mar 30.

Endurance exercise increases skeletal muscle kynurenine aminotransferases and plasma kynurenic acid in humans.

Author information

1
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Sports Science and Innovation Institute, Lithuanian Sports University, Kaunas, Lithuania;
2
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden;
3
Sports Science and Innovation Institute, Lithuanian Sports University, Kaunas, Lithuania;
4
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden; Department of Medicine, Unit of Cardiology, Karolinska Institutet, Stockholm, Sweden; and Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden Daniel.C.Andersson@ki.se.

Abstract

Physical exercise has emerged as an alternative treatment for patients with depressive disorder. Recent animal studies show that exercise protects from depression by increased skeletal muscle kynurenine aminotransferase (KAT) expression which shifts the kynurenine metabolism away from the neurotoxic kynurenine (KYN) to the production of kynurenic acid (KYNA). In the present study, we investigated the effect of exercise on kynurenine metabolism in humans. KAT gene and protein expression was increased in the muscles of endurance-trained subjects compared with untrained subjects. Endurance exercise caused an increase in plasma KYNA within the first hour after exercise. In contrast, a bout of high-intensity eccentric exercise did not lead to increased plasma KYNA concentration. Our results show that regular endurance exercise causes adaptations in kynurenine metabolism which can have implications for exercise recommendations for patients with depressive disorder.

KEYWORDS:

endurance exercise; kynurenic acid; kynurenine aminotransferases; skeletal muscle

PMID:
27030575
DOI:
10.1152/ajpcell.00053.2016
[Indexed for MEDLINE]
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