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ZBTB33 zinc finger and BTB domain containing 33 [ Homo sapiens (human) ]

Gene ID: 10009, updated on 3-Nov-2024

Summary

Official Symbol
ZBTB33provided by HGNC
Official Full Name
zinc finger and BTB domain containing 33provided by HGNC
Primary source
HGNC:HGNC:16682
See related
Ensembl:ENSG00000177485 MIM:300329; AllianceGenome:HGNC:16682
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF348; ZNF-kaiso
Summary
This gene encodes a transcriptional regulator with bimodal DNA-binding specificity, which binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. The protein contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. It may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. It also interacts directly with the nuclear import receptor Importin-α2 (also known as karyopherin alpha2 or RAG cohort 1), which may mediate nuclear import of this protein. Alternatively spliced transcript variants encoding the same protein have been identified.[provided by RefSeq, May 2010]
Expression
Ubiquitous expression in skin (RPKM 10.2), bone marrow (RPKM 8.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB33 in Genome Data Viewer
Location:
Xq24
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (120250812..120258398)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (118625869..118633458)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (119384667..119392253)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 30 Neighboring gene Sharpr-MPRA regulatory region 12959 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:119384374-119385212 Neighboring gene NFKB activating protein pseudogene 1 Neighboring gene transmembrane protein 255A Neighboring gene prefoldin subunit 4-like Neighboring gene NANOG hESC enhancer GRCh37_chrX:119408635-119409312 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29903 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chrX:119466056-119466798 Neighboring gene NANOG hESC enhancer GRCh37_chrX:119474477-119474999 Neighboring gene ATPase Na+/K+ transporting family member beta 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin ISA
Inferred from Sequence Alignment
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
transcriptional regulator Kaiso
Names
WUGSC:H_DJ525N14.1
kaiso transcription factor
zinc finger and BTB domain-containing protein 33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021334.1 RefSeqGene

    Range
    5061..12647
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001184742.2NP_001171671.1  transcriptional regulator Kaiso

    See identical proteins and their annotated locations for NP_001171671.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC002086, AK312321, BC042753, DB468333
    Consensus CDS
    CCDS14596.1
    UniProtKB/Swiss-Prot
    B2R5U6, O00319, Q7Z361, Q86T24, Q8IVP6, Q8N3P0
    Related
    ENSP00000450969.1, ENST00000557385.2
    Conserved Domains (4) summary
    smart00225
    Location:33116
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22116
    BTB; BTB/POZ domain
    pfam13465
    Location:508531
    zf-H2C2_2; Zinc-finger double domain
  2. NM_006777.4NP_006768.1  transcriptional regulator Kaiso

    See identical proteins and their annotated locations for NP_006768.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC002086, BC042753, BX538016
    Consensus CDS
    CCDS14596.1
    UniProtKB/Swiss-Prot
    B2R5U6, O00319, Q7Z361, Q86T24, Q8IVP6, Q8N3P0
    Related
    ENSP00000314153.2, ENST00000326624.2
    Conserved Domains (4) summary
    smart00225
    Location:33116
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:496516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00651
    Location:22116
    BTB; BTB/POZ domain
    pfam13465
    Location:508531
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    120250812..120258398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    118625869..118633458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)