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ERN2 endoplasmic reticulum to nucleus signaling 2 [ Equus caballus (horse) ]

Gene ID: 100069133, updated on 8-Mar-2024

Summary

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Official Symbol
ERN2provided by VGNC
Official Full Name
endoplasmic reticulum to nucleus signaling 2provided by VGNC
Primary source
VGNC:VGNC:112272
See related
Ensembl:ENSECAG00000017742
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 13
Exon count:
22
Annotation release Status Assembly Chr Location
103 current EquCab3.0 (GCF_002863925.1) 13 NC_009156.3 (24844041..24862887)
102 previous assembly EquCab2.0 (GCF_000002305.2) 13 NC_009156.2 (23753353..23772335)

Chromosome 13 - NC_009156.3Genomic Context describing neighboring genes Neighboring gene protein kinase C beta Neighboring gene cAMP-dependent protein kinase inhibitor gamma pseudogene Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene polo like kinase 1 Neighboring gene dynactin subunit 5 Neighboring gene partner and localizer of BRCA2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRE1-mediated unfolded protein response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of IRE1-TRAF2-ASK1 complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Equus caballus Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009156.3 Reference EquCab3.0 Primary Assembly

    Range
    24844041..24862887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023616112.1 → XP_023471880.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    UniProtKB/TrEMBL
    A0A9L0R1F9, A0A9L0RBA3
    Related
    ENSECAP00000055484.1, ENSECAT00000143978.1
    Conserved Domains (3) summary
    cd09769
    Location:39 → 367
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:785 → 910
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:517 → 782
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  2. XM_023616113.1 → XP_023471881.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X2

    UniProtKB/TrEMBL
    A0A5F5PJN0, A0A9L0RBA3
    Related
    ENSECAP00000048516.2, ENSECAT00000065784.2
    Conserved Domains (3) summary
    cd09769
    Location:39 → 367
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:784 → 909
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:516 → 781
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

  3. XM_023616114.1 → XP_023471882.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X3

    UniProtKB/TrEMBL
    F6QER4
    Related
    ENSECAP00000015293.4, ENSECAT00000018731.4
    Conserved Domains (3) summary
    cd10422
    Location:712 → 837
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:444 → 709
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:9 → 294
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  4. XM_023616115.1 → XP_023471883.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X4

    UniProtKB/TrEMBL
    F6QER4
    Conserved Domains (3) summary
    cd10422
    Location:683 → 808
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:415 → 680
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:1 → 265
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins

  5. XM_023616116.1 → XP_023471884.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X5

    UniProtKB/TrEMBL
    F6QER4
    Conserved Domains (3) summary
    cd10422
    Location:621 → 746
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    cd13982
    Location:353 → 618
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:34 → 203
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
Nucleotide Protein
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