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ERN2 endoplasmic reticulum to nucleus signaling 2 [ Homo sapiens (human) ]

Gene ID: 10595, updated on 1-Jun-2020

Summary

Official Symbol
ERN2provided by HGNC
Official Full Name
endoplasmic reticulum to nucleus signaling 2provided by HGNC
Primary source
HGNC:HGNC:16942
See related
Ensembl:ENSG00000134398 MIM:604034
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IRE1b; IRE2p; hIRE2p; IRE1-BETA
Expression
Biased expression in stomach (RPKM 26.7), colon (RPKM 17.0) and 5 other tissues See more
Orthologs

Genomic context

See ERN2 in Genome Data Viewer
Location:
16p12.2
Exon count:
24
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (23690310..23713248, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (23701625..23724821, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene partner and localizer of BRCA2 Neighboring gene dynactin subunit 5 Neighboring gene polo like kinase 1 Neighboring gene calcineurin like EF-hand protein 2 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1865

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of endoplasmic reticulum to nucleus signaling 2 (ERN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
endonuclease activity IDA
Inferred from Direct Assay
more info
PubMed 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
magnesium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
IRE1-mediated unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
activation of JUN kinase activity IEA
Inferred from Electronic Annotation
more info
 
apoptotic chromosome condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA processing IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
rRNA catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
response to endoplasmic reticulum stress TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
IRE1-TRAF2-ASK1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
IRE1-TRAF2-ASK1 complex ISS
Inferred from Sequence or Structural Similarity
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
serine/threonine-protein kinase/endoribonuclease IRE2
Names
ER to nucleus signalling 2
IRE1 beta
IRE1, S. cerevisiae, homolog of
endoplasmic reticulum to nucleus signalling 2
inositol-requiring 1 beta
inositol-requiring protein 2
NP_001295149.2
NP_150296.4
XP_011544010.1
XP_011544011.1
XP_011544013.1
XP_011544014.1
XP_011544015.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308220.2NP_001295149.2  serine/threonine-protein kinase/endoribonuclease IRE2 isoform b precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    BU608100, EF560720, EF560739
    Consensus CDS
    CCDS76845.1
    UniProtKB/Swiss-Prot
    Q76MJ5
    UniProtKB/TrEMBL
    A5YM46, A5YM65, E7ETG2
    Related
    ENSP00000413812.2, ENST00000457008.6
    Conserved Domains (5) summary
    cd09769
    Location:38366
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:733858
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:468729
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1520
    Location:41237
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd13982
    Location:465730
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
  2. NM_033266.4NP_150296.4  serine/threonine-protein kinase/endoribonuclease IRE2 isoform a precursor

    See identical proteins and their annotated locations for NP_150296.4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BU608100, EF560720, EF560739
    Consensus CDS
    CCDS32407.2
    UniProtKB/Swiss-Prot
    Q76MJ5
    UniProtKB/TrEMBL
    A5YM46, A5YM65
    Related
    ENSP00000256797.5, ENST00000256797.9
    Conserved Domains (5) summary
    cd09769
    Location:38366
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    cd10422
    Location:785910
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:520781
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    COG1520
    Location:41237
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
    cd13982
    Location:517782
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    23690310..23713248 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545708.2XP_011544010.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    See identical proteins and their annotated locations for XP_011544010.1

    Conserved Domains (4) summary
    cd10422
    Location:641766
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:376637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13982
    Location:373638
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:4222
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
  2. XM_011545709.2XP_011544011.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X1

    See identical proteins and their annotated locations for XP_011544011.1

    Conserved Domains (4) summary
    cd10422
    Location:641766
    RNase_Ire1; RNase domain (also known as the kinase extension nuclease domain) of Ire1
    smart00220
    Location:376637
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13982
    Location:373638
    STKc_IRE1; Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1
    cl14874
    Location:4222
    Luminal_IRE1_like; The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins
  3. XM_011545711.2XP_011544013.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X2

    Conserved Domains (2) summary
    cd09769
    Location:38366
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    COG1520
    Location:41237
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
  4. XM_011545713.1XP_011544015.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X4

    Conserved Domains (2) summary
    cd09769
    Location:38366
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    COG1520
    Location:41237
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]
  5. XM_011545712.2XP_011544014.1  serine/threonine-protein kinase/endoribonuclease IRE2 isoform X3

    Conserved Domains (2) summary
    cd09769
    Location:38366
    Luminal_IRE1; The Luminal domain, a dimerization domain, of the Serine/Threonine protein kinase, Inositol-requiring protein 1
    COG1520
    Location:41237
    PQQ; Outer membrane protein assembly factor BamB, contains PQQ-like beta-propeller repeat [Cell wall/membrane/envelope biogenesis]

RNA

  1. XR_950727.1 RNA Sequence

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