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Ddx43 DEAD box helicase 43 [ Mus musculus (house mouse) ]

Gene ID: 100048658, updated on 12-May-2024

Summary

Official Symbol
Ddx43provided by MGI
Official Full Name
DEAD box helicase 43provided by MGI
Primary source
MGI:MGI:3642857
See related
Ensembl:ENSMUSG00000070291 AllianceGenome:MGI:3642857
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable RNA binding activity and RNA helicase activity. Orthologous to human DDX43 (DEAD-box helicase 43). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 3.0), limb E14.5 (RPKM 0.4) and 6 other tissues See more
Orthologs
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Genomic context

See Ddx43 in Genome Data Viewer
Location:
9 E1; 9 43.65 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (78303059..78330871)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (78395777..78423589)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene oocyte expressed protein Neighboring gene 60S ribosomal protein L9-like Neighboring gene STARR-positive B cell enhancer mm9_chr9:78278373-78278674 Neighboring gene predicted gene 8093 Neighboring gene cyclic GMP-AMP synthase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (2) 

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX43
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
NP_001177973.1
XP_006510797.1
XP_006510798.1
XP_036010385.1
XP_036010386.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191044.1NP_001177973.1  probable ATP-dependent RNA helicase DDX43

    Status: PROVISIONAL

    Source sequence(s)
    AC138587, AC158987
    Consensus CDS
    CCDS52870.1
    UniProtKB/TrEMBL
    D3Z6P9
    Related
    ENSMUSP00000108994.2, ENSMUST00000113367.2
    Conserved Domains (4) summary
    smart00487
    Location:255453
    DEXDc; DEAD-like helicases superfamily
    cd00079
    Location:461588
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00105
    Location:73127
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00268
    Location:249446
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    78303059..78330871
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154492.1XP_036010385.1  probable ATP-dependent RNA helicase DDX43 isoform X1

    Conserved Domains (2) summary
    PTZ00110
    Location:169580
    PTZ00110; helicase; Provisional
    cd22430
    Location:68133
    KH-I_DDX43_DDX53; type I K homology (KH) RNA-binding domain found in DEAD box protein 43 (DDX43), DEAD box protein 53 (DDX53) and similar proteins
  2. XM_006510735.5XP_006510798.1  probable ATP-dependent RNA helicase DDX43 isoform X4

    Conserved Domains (2) summary
    pfam00013
    Location:73129
    KH_1; KH domain
    cl28899
    Location:251343
    DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
  3. XM_036154493.1XP_036010386.1  probable ATP-dependent RNA helicase DDX43 isoform X2

    Conserved Domains (1) summary
    PTZ00110
    Location:23435
    PTZ00110; helicase; Provisional
  4. XM_006510734.1XP_006510797.1  probable ATP-dependent RNA helicase DDX43 isoform X3

    Conserved Domains (1) summary
    PTZ00110
    Location:1347
    PTZ00110; helicase; Provisional

RNA

  1. XR_379393.2 RNA Sequence

  2. XR_004935286.1 RNA Sequence