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DDX43 DEAD-box helicase 43 [ Homo sapiens (human) ]

Gene ID: 55510, updated on 25-Jan-2022

Summary

Official Symbol
DDX43provided by HGNC
Official Full Name
DEAD-box helicase 43provided by HGNC
Primary source
HGNC:HGNC:18677
See related
Ensembl:ENSG00000080007 MIM:606286; AllianceGenome:HGNC:18677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT13; HAGE
Summary
The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 12.4), placenta (RPKM 1.9) and 3 other tissues See more
Orthologs
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Genomic context

See DDX43 in Genome Data Viewer
Location:
6q13
Exon count:
17
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (73394828..73417566)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (74104551..74127289)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein L39 pseudogene 3 Neighboring gene ribosomal protein S6 pseudogene 8 Neighboring gene cyclic GMP-AMP synthase Neighboring gene RNA, U6 small nuclear 975, pseudogene Neighboring gene mitochondrial tRNA translation optimization 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434H2114

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
probable ATP-dependent RNA helicase DDX43
Names
DEAD (Asp-Glu-Ala-Asp) box polypeptide 43
DEAD box protein HAGE
DEAD-box protein 43
cancer/testis antigen 13
helical antigen
NP_061135.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018665.3NP_061135.2  probable ATP-dependent RNA helicase DDX43

    See identical proteins and their annotated locations for NP_061135.2

    Status: REVIEWED

    Source sequence(s)
    BC066938, BQ020439, BX646425, DA453913
    Consensus CDS
    CCDS4977.1
    UniProtKB/Swiss-Prot
    Q9NXZ2
    Related
    ENSP00000359361.4, ENST00000370336.5
    Conserved Domains (4) summary
    PTZ00424
    Location:241622
    PTZ00424; helicase 45; Provisional
    cd00079
    Location:461589
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    cd00105
    Location:76128
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00268
    Location:251448
    DEADc; DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    73394828..73417566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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