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    EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Pongo abelii (Sumatran orangutan) ]

    Gene ID: 100447447, updated on 26-Mar-2024

    Summary

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    Gene symbol
    EZH2
    Gene description
    enhancer of zeste 2 polycomb repressive complex 2 subunit
    Locus tag
    CR201_G0045748
    See related
    Ensembl:ENSPPYG00000018147
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Pongo abelii
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pongo
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 6
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPonAbe1-v2.0_pri (GCF_028885655.2) 6 NC_071991.2 (146379163..146455277, complement)
    RS_2023_04 previous assembly NHGRI_mPonAbe1-v1.1-hic.freeze_pri (GCF_028885655.1) 7 NC_071992.1 (140200953..140277067, complement)

    Chromosome 6 - NC_071991.2Genomic Context describing neighboring genes Neighboring gene huntingtin-interacting protein K-like Neighboring gene cullin 1 Neighboring gene U7 small nuclear RNA Neighboring gene U6 spliceosomal RNA Neighboring gene protein disulfide isomerase family A member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables chromatin binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables histone H3K27 methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in heterochromatin formation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of ESC/E(Z) complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    histone-lysine N-methyltransferase EZH2
    Names
    enhancer of zeste homolog 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_028885655.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

    Genomic

    1. NC_071991.2 Reference NHGRI_mPonAbe1-v2.0_pri Primary Assembly

      Range
      146379163..146455277 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063725805.1 → XP_063581875.1  histone-lysine N-methyltransferase EZH2 isoform X11

    2. XM_054560701.1 → XP_054416676.1  histone-lysine N-methyltransferase EZH2 isoform X10

    3. XM_024250000.3 → XP_024105768.1  histone-lysine N-methyltransferase EZH2 isoform X3

      UniProtKB/TrEMBL
      A0A2J8S6W0
      Related
      ENSPPYP00000039887.1
      Conserved Domains (4) summary
      cd19218
      Location:609 → 728
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158 → 249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:559 → 590
      preSET_CXC; CXC domain

    4. XM_054560699.1 → XP_054416674.1  histone-lysine N-methyltransferase EZH2 isoform X6

      UniProtKB/TrEMBL
      A0A2J8S6W5

    5. XM_024249999.3 → XP_024105767.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      A0A2J8S6W3, H2PNY7
      Related
      ENSPPYP00000020354.2
      Conserved Domains (4) summary
      cd19218
      Location:614 → 733
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:158 → 249
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:564 → 595
      preSET_CXC; CXC domain

    6. XM_024250002.2 → XP_024105770.1  histone-lysine N-methyltransferase EZH2 isoform X12

      UniProtKB/TrEMBL
      A0A2J8S6X6, K7ESX8
      Related
      ENSPPYP00000023646.2
      Conserved Domains (4) summary
      cd19218
      Location:570 → 689
      SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
      pfam11616
      Location:39 → 68
      EZH2_WD-Binding; WD repeat binding protein EZH2
      pfam18118
      Location:119 → 210
      PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
      pfam18264
      Location:520 → 551
      preSET_CXC; CXC domain

    7. XM_054560707.2 → XP_054416682.1  histone-lysine N-methyltransferase EZH2 isoform X14

    8. XM_054560706.2 → XP_054416681.1  histone-lysine N-methyltransferase EZH2 isoform X13

    9. XM_054560692.1 → XP_054416667.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      A0A2J8S6W3, H2PNY7

    10. XM_054560693.1 → XP_054416668.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      A0A2J8S6W3, H2PNY7

    11. XM_054560691.1 → XP_054416666.1  histone-lysine N-methyltransferase EZH2 isoform X1

      UniProtKB/TrEMBL
      A0A2J8S6W3, H2PNY7

    12. XM_054560700.1 → XP_054416675.1  histone-lysine N-methyltransferase EZH2 isoform X7

    13. XM_054560697.1 → XP_054416672.1  histone-lysine N-methyltransferase EZH2 isoform X5

    14. XM_054560695.1 → XP_054416670.1  histone-lysine N-methyltransferase EZH2 isoform X4

    15. XM_054560696.2 → XP_054416671.1  histone-lysine N-methyltransferase EZH2 isoform X2

    16. XM_063725803.1 → XP_063581873.1  histone-lysine N-methyltransferase EZH2 isoform X8

    17. XM_063725804.1 → XP_063581874.1  histone-lysine N-methyltransferase EZH2 isoform X9

    Nucleotide Protein
    Heading Accession and Version

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