5HYN,5IJ8,4MI0,5LS6,4MI5,5IJ7,5WG6


Conserved Protein Domain Family
SET_EZH2
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cd19218: SET_EZH2 
SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
EZH2 (EC 2.1.1.43), also termed lysine N-methyltransferase 6, or ENX-1, or histone-lysine N-methyltransferase EZH2, is a catalytic subunit of the polycomb repressive complex 2 (PRC2)/EED-EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. It can mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. PRC2 is involved in several cancers; EZH2 is overexpressed in breast, liver and prostate cancer, while point mutations in EZH2 alter the substrate preference and product specificity of PRC2 in Non-Hodgkin lymphomas (NHLs). Thus, PRC2 is a popular target for cancer therapeutics.
Links
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Statistics
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PSSM-Id: 380995
Aligned: 20 rows
Threshold Bit Score: 270.631
Created: 12-Jun-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5HYN; Homo sapiens polycomb repressive complex 2 (prc2) binds H3k27m peptide and S-adenosyl-L-homocysteine, contacts at 4A.
    - View structure with Cn3D
Download Cn3D for Viewing 3D StructureScroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                    ####                #      #  ##  #   #  #######                ####
5HYN_A       609 GSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 688 human
NP_001070747 623 GAKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 702 zebrafish
XP_007904512 555 GSKKHLLLAPSDVAGWGIFIKEPVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 634 elephant shark
XP_011671756 663 GWKRHLLLAPSDVAGWGIYITVPVMKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 742 purple sea urchin
P42124       623 GLHKHLLMAPSDIAGWGIFLKEGAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 702 fruit fly
EKC36964     670 GMKKHLLLAPSDIAGWGIFLKVPAEKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 749 Pacific oyster
EFX90346     653 GLRKHLLMAPSDVAGWGIFLKETVQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 732 common water flea
XP_019621342 641 GLRKHLLLAPSDVAGWGIFLKTSAQKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNKIRFAN 720 Belcher's lancelet
ESO04666     486 GMKKHLLLAPSDVAGWGIFLKESCEKNEFISEYCGEVITQDEADRRGKVYDRYMCSFLFNLNSDFVVDATRKGNKIRFAN 565 Helobdella robusta
XP_013421189 715 GLRKHLLLAPSDVAGWGIFLKEAAEKNEFISEYCGEIISQDEADRRGKVYDKYMCSFLFNLNNDYVVDATRKGNKIRFAN 794 Lingula anatina

Feature 1        #       #                          # ## 
5HYN_A       689 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 728 human
NP_001070747 703 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 742 zebrafish
XP_007904512 635 HSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELFFDYRY 674 elephant shark
XP_011671756 743 HSNMPNCYAKVMMVNGDHRIGIFAKRNIQTGEELFFDYSA 782 purple sea urchin
P42124       703 HSINPNCYAKVMMVTGDHRIGIFAKRAIQPGEELFFDYRY 742 fruit fly
EKC36964     750 HSVNPNCYAKVMMVNGDHRIGIFAKRPIQAGEELFFDYRY 789 Pacific oyster
EFX90346     733 HSINPNCYAKVMMVNGDHRIGIFAKRFIHSGEELFFDYRY 772 common water flea
XP_019621342 721 HSVNPNCYAKVMMVNGDHRIGIFAKRPIQPGEELFFDYRY 760 Belcher's lancelet
ESO04666     566 HSINPNCYAKVMMVNGDHRIGIFAKRAIQAGEELFFDYRY 605 Helobdella robusta
XP_013421189 795 HSVNPNCYAKVMMVNGDHRIGICAKRPIQAGEELFFDYRY 834 Lingula anatina

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