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    CCNA1 cyclin A1 [ Homo sapiens (human) ]

    Gene ID: 8900, updated on 3-Apr-2024

    Summary

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    Official Symbol
    CCNA1provided by HGNC
    Official Full Name
    cyclin A1provided by HGNC
    Primary source
    HGNC:HGNC:1577
    See related
    Ensembl:ENSG00000133101 MIM:604036; AllianceGenome:HGNC:1577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CT146
    Summary
    The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle. This cyclin was found to bind to important cell cycle regulators, such as Rb family proteins, transcription factor E2F-1, and the p21 family proteins. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward testis (RPKM 24.4) See more
    Orthologs
    mouse all
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    Genomic context

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    Location:
    13q13.3
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (36431517..36442870)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (35651206..35662375)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (37006092..37017007)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene CCDC169-SOHLH2 readthrough Neighboring gene coiled-coil domain containing 169 Neighboring gene Sharpr-MPRA regulatory region 14903 Neighboring gene RNA, U6 small nuclear 71, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36871578-36872539 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36872540-36873502 Neighboring gene NANOG hESC enhancer GRCh37_chr13:36887598-36888362 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36890200-36891034 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36891035-36891868 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:36894061-36894764 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36895467-36896169 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr13:36896170-36896871 Neighboring gene Sharpr-MPRA regulatory region 3304 Neighboring gene spartin Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5263 Neighboring gene SPART antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:36962882-36963065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5264 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5265 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5266 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:37011626-37012825 Neighboring gene H2AC histone family pseudogene 1 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr13:37101466-37101966 Neighboring gene uncharacterized LOC124903155

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia. Ge M, et al. Cancer Sci, 2021 Jun. PMID 33738896, Free PMC Article
    2. CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer. da Silva RM, et al. Acta Histochem, 2020 Dec. PMID 33007517
    3. Value of CCNA1 promoter methylation in triaging ASC-US cytology. Oranratanaphan S, et al. Asian Pac J Cancer Prev, 2020 Feb 1. PMID 32102526, Free PMC Article
    4. Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells. Akaike Y, et al. Cell Cycle, 2020 Jan. PMID 31760882, Free PMC Article
    5. CCNA1 promoter methylation: a potential marker for grading Papanicolaou smear cervical squamous intraepithelial lesions. Chujan S, et al. Asian Pac J Cancer Prev, 2014. PMID 25292097

    See all (162) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
      Title: Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts.
    2. [Cyclin A1 affects the invasion, metastasis, and prognosis of hepatocellular carcinoma].
      Title: [Cyclin A1 affects the invasion, metastasis, and prognosis of hepatocellular carcinoma].
    3. Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia.
      Title: Histone methyltransferase EZH2 epigenetically affects CCNA1 expression in acute myeloid leukemia.
    4. The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.
      Title: The combined detection of Amphiregulin, Cyclin A1 and DDX20/Gemin3 expression predicts aggressive forms of oral squamous cell carcinoma.
    5. CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer.
      Title: CCNA1 gene as a potential diagnostic marker in papillary thyroid cancer.
    6. Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
      Title: Deubiquitinating enzyme inhibitor alleviates cyclin A1-mediated proteasome inhibitor tolerance in mixed-lineage leukemia.
    7. Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells.
      Title: Aberrant activation of cyclin A-CDK induces G2/M-phase checkpoint in human cells.
    8. Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.
      Title: Expression and prognosis of CyclinA and CDK2 in patients with advanced cervical cancer after chemotherapy.
    9. Value of CCNA1 promoter methylation in triaging ASC-US cytology.
      Title: Value of CCNA1 promoter methylation in triaging ASC-US cytology.
    10. immunopeptidome of HeLa cells transfected with Cyclin A1 and HLA-A*02:01 revealed six Cyclin A1-derived HLA ligands
      Title: Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo.
    Submit: New GeneRIF Correction See all GeneRIFs (63)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat When expressed in astrocytes, neurons, and non-glial 293T cells, HIV-1 Tat interacts with a number of cell cycle-related proteins including cyclin A, cyclin B, cyclin D3, Cdk2, Cdk4, Cdk1/Cdc2, cdc6, p27, p53, p63, hdlg, and PCNA PubMed
    Vif vif HIV-1 Vif upregulates the expression of cyclin A1 (CCNA1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in male meiosis I TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic cell cycle phase transition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cyclin-dependent protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spermatogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin A1-CDK2 complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin A2-CDK2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in microtubule cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cyclin-A1
    Names
    testicular tissue protein Li 34

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001111045.4 → NP_001104515.2  cyclin-A1

      Status: REVIEWED

      Source sequence(s)
      AL359767
      Related
      ENSP00000486017.2, ENST00000625767.2

    2. NM_001111046.2 → NP_001104516.1  cyclin-A1

      See identical proteins and their annotated locations for NP_001104516.1

      Status: REVIEWED

      Source sequence(s)
      CD171793, U66838
      Consensus CDS
      CCDS45031.1
      UniProtKB/TrEMBL
      A0A140VJG0
      Related
      ENSP00000400666.1, ENST00000440264.5
      Conserved Domains (2) summary
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    3. NM_001111047.2 → NP_001104517.1  cyclin-A1

      See identical proteins and their annotated locations for NP_001104517.1

      Status: REVIEWED

      Source sequence(s)
      BC036346, DC395631
      Consensus CDS
      CCDS45031.1
      UniProtKB/TrEMBL
      A0A140VJG0
      Conserved Domains (2) summary
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    4. NM_001413923.1 → NP_001400852.1  cyclin-A1

      Status: REVIEWED

      Source sequence(s)
      AL359767
      Related
      ENSP00000255465.5, ENST00000255465.8

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      36431517..36442870
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011535294.3 → XP_011533596.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_011533596.1

      UniProtKB/TrEMBL
      A0A140VJG0
      Related
      ENSP00000486482.1, ENST00000630422.2
      Conserved Domains (2) summary
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    2. XM_011535295.3 → XP_011533597.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_011533597.1

      UniProtKB/TrEMBL
      A0A140VJG0
      Conserved Domains (2) summary
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    3. XM_011535296.3 → XP_011533598.1  cyclin-A1 isoform X1

      See identical proteins and their annotated locations for XP_011533598.1

      UniProtKB/TrEMBL
      A0A140VJG0
      Conserved Domains (2) summary
      cd20560
      Location:132 → 294
      CYCLIN_CCNA1_rpt1; first cyclin box found in cyclin-A1 (CCNA1)
      cd20563
      Location:298 → 420
      CYCLIN_CCNA1_rpt2; second cyclin box found in cyclin-A1 (CCNA1) and similar proteins

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      35651206..35662375
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375156.1 → XP_054231131.1  cyclin-A1 isoform X1

    2. XM_054375155.1 → XP_054231130.1  cyclin-A1 isoform X1

    3. XM_054375154.1 → XP_054231129.1  cyclin-A1 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_003914.4: Suppressed sequence

      Description
      NM_003914.4: This RefSeq was removed because currently there is insufficient support for the translation start site.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78396.1 GenPept UniProtKB/Swiss-Prot:P78396

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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