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    SP1 Sp1 transcription factor [ Homo sapiens (human) ]

    Gene ID: 6667, updated on 18-May-2013
    Official Symbol
    SP1provided by HGNC
    Official Full Name
    Sp1 transcription factorprovided by HGNC
    Primary source
    HGNC:11205
    See related
    Ensembl:ENSG00000185591; HPRD:01796; MIM:189906; Vega:OTTHUMG00000170047
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
    Location :
    12q13.1
    Sequence :
    Chromosome: 12; NC_000012.11 (53773979..53810230)
    See SP1 in Epigenomics, MapViewer

    Chromosome 12 - NC_000012.11Genomic Context describing neighboring genes Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene Sp7 transcription factor Neighboring gene anti-Mullerian hormone receptor, type II Neighboring gene proline rich 13

    Go to nucleotideGraphics FASTA GenBank

    Go to reference sequence details

    Related articles in PubMed

    1. Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding. Kim MK, et al. J Biol Chem, 2013 Mar 8. PMID 23329847.
    2. Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation. Paonessa F, et al. J Biol Chem, 2013 Feb 1. PMID 23250796.
    3. Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr+ Escherichia coli receptor protein decay accelerating factor (DAF or CD55) by nitric oxide. Banadakoppa M, et al. FEBS J, 2013 Feb. PMID 23176121.
    4. Neuron-restrictive silencer factor functions to suppress Sp1-mediated transactivation of human secretin receptor gene. Yuan Y, et al. Biochim Biophys Acta, 2013 Feb. PMID 23168245.
    5. [Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1]. Zhou CF, et al. Zhonghua Zhong Liu Za Zhi, 2012 Aug. PMID 23158992.

    See all (761) citations in PubMed

    See citations in PubMed for homologs of this gene provided by HomoloGene

    GeneRIFs: Gene References Into Functions What's a GeneRIF?

    1. DOX could modulate the expression of GCS through the Sp1 site of GCS promoter in ERalpha-positive breast cancer cells
      Title: Doxorubicin influences the expression of glucosylceramide synthase in invasive ductal breast cancer.
    2. MTA2 expression was concomitant with Sp1 expression in gastric cancer.
      Title: [Expression of metastasis associated 1 family member 2 (MTA2) in gastric cancer and its relationship with transcription factor Sp1].
    3. Data indicate BOZF1 represses transcription of CDKN1A by inhibition of p53 acetylation and Sp1 binding.
      Title: Regulation of the cyclin-dependent kinase inhibitor 1A gene (CDKN1A) by the repressor BOZF1 through inhibition of p53 acetylation and transcription factor Sp1 binding.
    4. Taken together, we propose here that the down-regulatory effects of NRSF on hSCTR gene expression are mediated via its suppression on Sp1-mediated transactivation
      Title: Neuron-restrictive silencer factor functions to suppress Sp1-mediated transactivation of human secretin receptor gene.
    5. BA treatment in HeLa cells increased the sumoylation of Sp1.
      Title: Betulinic acid decreases specificity protein 1 (Sp1) level via increasing the sumoylation of sp1 to inhibit lung cancer growth.
    6. The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking.
      Title: The transcription factor Sp1 is responsible for aging-dependent altered nucleocytoplasmic trafficking.
    7. Data indicate that nitric oxide downregulates decay accelerating factor (DAF) expression by inhibiting its promoter activity possibly through a decreased binding of Sp1 in association of HuR.
      Title: Role of transcription factor Sp1 and RNA binding protein HuR in the downregulation of Dr+ Escherichia coli receptor protein decay accelerating factor (DAF or CD55) by nitric oxide.
    8. These studies suggest that transcription factor SP1 may be involved in the pathogenesis of prion diseases.
      Title: Transcriptional regulation of specific protein 1 (SP1) by hypoxia-inducible factor 1 alpha (HIF-1α) leads to PRNP expression and neuroprotection from toxic prion peptide.
    9. these results indicate that Sp1 is essential for Keap1 expression and that promoter methylation blocks Sp1 binding in A549 cells
      Title: A possible gene silencing mechanism: hypermethylation of the Keap1 promoter abrogates binding of the transcription factor Sp1 in lung cancer cells.
    10. A conserved region of human and mouse SYN1 promoters contains cis-sites for the transcriptional activator Sp1 in close proximity to REST binding motifs.
      Title: Specificity protein 1 (Sp1)-dependent activation of the synapsin I gene (SYN1) is modulated by RE1-silencing transcription factor (REST) and 5'-cytosine-phosphoguanine (CpG) methylation.
    Submit: New GeneRIF Correction See all (481)

    Review eQTL and phenotype association data in this region using PheGenI

    Protein Gene Interaction Pubs
    Tat, p14 tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
    tat Sp1 and Sp1-binding sites in the HIV-1 LTR promoter are required for HIV-1 Tat-mediated activation of viral transcription elongation PubMed
    tat Sp1 synergizes with HIV-1 Tat to activate HIV-1 transcription PubMed
    tat HIV-1 Tat expression inhibits the TCF-4-induced inhibition of Sp1 phosphorylation and Sp1-mediated HIV-1 LTR transcription PubMed
    tat Hydroxyurea and IL-6 synergistically enhance HIV-1 Tat activation of HIV-1 LTR-driven transcription via the Sp1 binding site PubMed
    tat HIV-1 Tat binds to DNA-PK and augments DNA-PK-mediated phosphorylation of Sp1 during Tat transactivation of the HIV-1 LTR promoter PubMed
    tat HIV-1 Tat downregulates SOD2 expression by interacting with Sp1 and Sp3 to increase the Sp3-containing complexes on the basal SOD2 promoter PubMed
    tat In hepatic cells, HIV-1 Tat expression upregulates Sp1 and Sp3, which play different roles in regulating MnSOD transcription (overexpression of Sp1 stimulates, while overexpression of Sp3 represses transcriptional activity) PubMed
    tat HIV-1 Tat represses transcription from the MHC class I, MDR1, minimal SV40 and other Sp1-dependent promoters, indicating Tat downregulates expression from these promoters by inhibiting Sp1 function PubMed
    tat HIV-1 Tat increases Sp1 binding in HeLa cells, suggesting Tat changes the conformation of Sp1 in order to regulate its function during HIV-1 transcription activation PubMed
    tat Sp1, COUP-TF and HIV-1 Tat interact and cooperate in the transcriptional activation of the HIV-1 LTR promoter in human microglial cells PubMed
    tat HIV-1 Tat upregulates the expression of galectin-3, NOS-3, and monocyte chemoattractant protein 1 (MCP-1) through Sp1 activation PubMed
    tat YB-1 and Sp1 exert negative effects on each other's function in enhancing transcription from the HIV-1 promoter, suggesting an interplay between these two proteins during regulation of HIV-1 Tat function PubMed
    tat The tumor suppressor protein p53 inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter through an interaction with the Sp1 sites in the LTR, suggesting an inhibition of Sp1 effects on Tat function PubMed
    tat HIV-1 Tat amino acids 30-55 mediate binding of Tat to Sp1, an effect that some reports indicate is a direct binding interaction, while other reports suggest it is indirect and possibly mediated through interaction with other cellular factors PubMed
    tat HIV-1 Tat cooperates with Sp1 to enhance transcript elongation, leading to exon skipping and effects on splicing PubMed
    Vpr, p15 vpr HIV-1 Vpr induces HIF-1alpha expression, which involves the presence of Sp1 and the p65 subunit of NFkappaB transcription factors PubMed
    vpr HIV-1 Vpr interacts with Sp1 in the context of an Sp1-DNA complex that may also include p53, resulting in the transactivation of the HIV-1 LTR promoter PubMed
    vpr HIV-1 Vpr activates promoter activity of p21/Cip1/Waf1 through the GC-rich region located between nucleotides -84 and -74 in a manner that requires cooperativity of Sp1, which binds to the DNA sequence spanning -84 to -74 PubMed
    vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
    nucleocapsid gag HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription PubMed

    Go to the HIV-1, Human Protein Interaction Database

    Products Interactant Other Gene Complex Source Pubs Description
    AAF67726.1 NP_009227.1 BRCA1    BIND  PubMed BRCA1 interacts with Sp1. 
    AAF67726.1 NP_001955.1 EGR1    BIND  PubMed Egr1 interacts with Sp1.This interaction was modelled on a demonstrated interaction between human Egr1 and mouse Sp1. 
    AAF67726.1 NP_002458.1 MYC    BIND  PubMed Myc interacts with Sp1. This interaction was modeled on a demonstrated interaction between mouse Myc and human Sp-1. 
    NC_000012.9     BIND  PubMed RNAPII interacts with Sp1. 
    NP_612482.2 NP_060649.3 ATF7IP    BIND  PubMed MCAF1 interacts with Sp1. 
    NP_612482.2 NP_079273.2 ATF7IP2    BIND  PubMed MCAF2 interacts with Sp1. 
    NP_612482.2 NC_000019.8 CD209    BIND  PubMed Sp1 interacts with the CD209 promoter. 
    NP_612482.2 AY497474.1 CDC25C    BIND  PubMed Sp1 interacts with the cdc25c promoter. 
    NP_612482.2 NC_000006.9 CDKN1A    BIND  PubMed SP1 interacts with the CDKN1A (p21) promoter. 
    NP_612482.2 Z85996.1 CDKN1A    BIND  PubMed Sp1 interacts with CDKN1A promoter. 
    NP_612482.2 NT_007914.14 CLCN1    BIND  PubMed p-CLCN1 interacts with Sp1. 
    NP_612482.2 NM_004409.2 DMPK    BIND  PubMed Mutant DMPK mRNA interacts with Sp1. 
    NP_612482.2 HIF1A    BIND  PubMed Sp1 interacts with HIF-1alpha. 
    NP_612482.2 NP_002102.2 HTT    BIND  PubMed Huntingtin interacts with Sp1. This interaction was modelled on a demonstrated interaction between Huntingtin from human and Sp1 from rat. 
    NP_612482.2 NC_000012.9 MDM2    BIND  PubMed SP1 interacts with the MDM2 intronic promoter. 
    NP_612482.2 NP_002458.1 MYC    BIND  PubMed Sp1 interacts with Myc. 
    NP_612482.2 AY525610.1 PGR    BIND  PubMed Sp1 interacts with the PgRB promoter. 
    NP_612482.2 AY525610.1 PGR    BIND  PubMed Sp1 interacts with the PgRA promoter. 
    NP_612482.2 NC_000008.9 RECQL4    BIND  PubMed SP1 interacts with the RECQL4 (RECQ4) promoter. 
    NP_612482.2 NC_000003.9 TNFSF10    BIND  PubMed SP1 interacts with the TNFSF10 promoter. 
    NP_612482.2 NP_000537.2 TP53    BIND  PubMed p53 interacts with Sp1. 
    NP_612482.2 NP_000537.2 TP53    BIND  PubMed TP53 (p53) interacts with Sp1. 
    NP_612482.2 NP_000537.2 TP53    BIND  PubMed TP53 (p53) interacts with SP1. 
    NP_612482.2 NP_000537.2 TP53    BIND  PubMed p53 interacts with Sp1. 
    NP_612482.2 NP_003394.1 YY1    BIND  PubMed YY1 interacts with Sp1. 
    NP_612482.2 NP_057864.1 tax    BIND  PubMed Tax interacts with Sp1. 
    NP_612482.2 NC_000002.9     BIND  PubMed Sp1 interacts with MSH2 promoter. 
    NP_612482.2 NC_000002.9     BIND  PubMed Sp1 interacts with MSH6 promoter. 
    NP_612482.2 NC_000011.7     BIND  PubMed Sp1 interacts with D2R promoter. 
    NP_612482.2 P04614     BIND  PubMed Tat interacts with Sp1. 
    NP_612482.2     BIND  PubMed DNA-PK phosphorylates Sp1. 
    P08047 Q9NY61 AATF    HPRD  PubMed  
    P08047 P10275 AR    HPRD  PubMed  
    P08047 Activating transcription factor 7 interacting protein ATF7IP    HPRD  PubMed  
    P08047 Activating transcription factor 7 interacting protein 2 ATF7IP2    HPRD  PubMed  
    P08047 P41182 BCL6    HPRD  PubMed  
    P08047 Q6W2J9 BCOR    HPRD  PubMed  
    P08047 P38398 BRCA1    HPRD  PubMed  
    P08047 P42574 CASP3    HPRD  PubMed  
    P08047 P24385 CCND1    HPRD  PubMed  
    P08047 P06729 CD2    HPRD  PubMed  
    P08047 P17676 CEBPB    HPRD  PubMed  
    P08047 P68400 CSNK2A1    HPRD  PubMed  
    P08047 Q9NRR4 DROSHA    HPRD  PubMed  
    P08047 Q01094 E2F1    HPRD  PubMed  
    P08047 Q14209 E2F2    HPRD  PubMed  
    P08047 O00716 E2F3    HPRD  PubMed  
    P08047 P18146 EGR1    HPRD  PubMed  
    P08047 P32519 ELF1    HPRD  PubMed  
    P08047 Q09472 EP300    HPRD  PubMed  
    P08047 P03372 ESR1    HPRD  PubMed  
    P08047 Q92731 ESR2    HPRD  PubMed  
    P08047 P14921 ETS1    HPRD  PubMed  
    P08047 Q06546 GABPA    HPRD  PubMed  
    P08047 P51610 HCFC1    HPRD  PubMed  
    P08047 Q13547 HDAC1    HPRD  PubMed  
    P08047 Q92769 HDAC2    HPRD  PubMed  
    P08047 Q16665 HIF1A    HPRD  PubMed  
    P08047 P17096 HMGA1    HPRD  PubMed  
    P08047 P41235 HNF4A    HPRD  PubMed  
    P08047 P11142 HSPA8    HPRD  PubMed  
    P08047 P42858 HTT    HPRD  PubMed  
    P08047 P05412 JUN    HPRD  PubMed  
    P08047 Q13118 KLF10    HPRD  PubMed  
    P08047 O43474 KLF4    HPRD  PubMed  
    P08047 Q99612 KLF6    HPRD  PubMed  
    P08047 P28482 MAPK1    HPRD  PubMed  
    P08047 P27361 MAPK3    HPRD  PubMed  
    P08047 Q06413 MEF2C    HPRD  PubMed  
    P08047 Q14814 MEF2D    HPRD  PubMed  
    P08047 Q8N108 MIER1    HPRD  PubMed  
    P08047 Q6P0N0 MIS18BP1    HPRD  PubMed  
    P08047 P28360 MSX1    HPRD  PubMed  
    P08047 P01106 MYC    HPRD  PubMed  
    P08047 P15172 MYOD1    HPRD  PubMed  
    P08047 P15173 MYOG    HPRD  PubMed  
    P08047 O75376 NCOR1    HPRD  PubMed  
    P08047 Q9Y618 NCOR2    HPRD  PubMed  
    P08047 P23511 NFYA    HPRD  PubMed  
    P08047 P25208 NFYB    HPRD  PubMed  
    P08047 P29474 NOS3    HPRD  PubMed  
    P08047 P10589 NR2F1    HPRD  PubMed  
    P08047 Q13285 NR5A1    HPRD  PubMed  
    P08047 O15294 OGT    HPRD  PubMed  
    P08047 P56645 PER3    HPRD  PubMed  
    P08047 P29590 PML    HPRD  PubMed  
    P08047 Q7Z3K3 POGZ    HPRD  PubMed  
    P08047 P14859 POU2F1    HPRD  PubMed  
    P08047 Q8WUF5 PPP1R13L    HPRD  PubMed  
    P08047 P78527 PRKDC    HPRD  PubMed  
    P08047 P62195 PSMC5    HPRD  PubMed  
    P08047 Q00577 PURA    HPRD  PubMed  
    P08047 P10276 RARA    HPRD  PubMed  
    P08047 P06400 RB1    HPRD  PubMed  
    P08047 Q09028 RBBP4    HPRD  PubMed  
    P08047 P28749 RBL1    HPRD  PubMed  
    P08047 Q04864 REL    HPRD  PubMed  
    P08047 Q04206 RELA    HPRD  PubMed  
    P08047 P19793 RXRA    HPRD  PubMed  
    P08047 Q15459 SF3A1    HPRD  PubMed  
    P08047 P29353 SHC1    HPRD  PubMed  
    P08047 P42285 SKIV2L2    HPRD  PubMed  
    P08047 Q15796 SMAD2    HPRD  PubMed  
    P08047 P84022 SMAD3    HPRD  PubMed  
    P08047 Q13485 SMAD4    HPRD  PubMed  
    P08047 P56693 SOX10    HPRD  PubMed  
    P08047 P57073 SOX8    HPRD  PubMed  
    P08047 P08047 SP1    HPRD  PubMed  
    P08047 Q02447 SP3    HPRD  PubMed  
    P08047 Q02446 SP4    HPRD  PubMed  
    P08047 P36956 SREBF1    HPRD  PubMed  
    P08047 Q12772 SREBF2    HPRD  PubMed  
    P08047 O00268 TAF4    HPRD  PubMed  
    P08047 P17542 TAL1    HPRD  PubMed  
    P08047 P20226 TBP    HPRD  PubMed  
    P08047 P04637 TP53    HPRD  PubMed  
    P08047 P40337 VHL    HPRD  PubMed  
    P08047 P25490 YY1    HPRD  PubMed  
    P08047 Q05516 ZBTB16    HPRD  PubMed  
    P08047 O95365 ZBTB7A    HPRD  PubMed  
    BioGRID:112550 BioGRID:117743 AATF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:131362 ACTBL2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:106585 ACTC1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:106586 ACTG1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:106699 AHR    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:106799 ANXA2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:106862 AR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:106898 ARNT    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:116586 ATF6    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:112550 BioGRID:120849 ATF7IP    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:123097 ATF7IP2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:122343 BCL11B    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:120228 BCOR    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:107140 BRCA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:107142 BRCA2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:971769 BRLF1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:114457 BTRC    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:107252 CALM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:107282 CAPZB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:107286 CASP3    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:107289 CASP6    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:107290 CASP7    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:117030 CBX5    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:114417 CCNA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:107331 CCNA2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:107332 CCNB1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:112550 BioGRID:107067 CCND1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:114947 CDC42BPB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:107420 CDK1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization 
    BioGRID:112550 BioGRID:107452 CDK2    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:107454 CDK4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:107463 CDKN2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:107480 CEBPB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:120223 CNTLN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:107678 COL3A1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:107777 CREBBP    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112550 BioGRID:107796 CRX    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:107869 CTBP1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:126653 CTCFL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:107995 DBN1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:120933 DCAF6    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:108020 DDX3X    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108038 DES    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:108123 DNMT1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:108201 E2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108278 EGR1    BioGRID  PubMed Affinity Capture-Western; Co-localization 
    BioGRID:112550 BioGRID:108312 ELF1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:108347 EP300    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Co-localization; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:108348 EPAS1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:108403 ESR1    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112550 BioGRID:108404 ESR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108405 ESRRA    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:108406 ESRRB    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:108407 ESRRG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:133180 FEZF1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:112550 BioGRID:117566 FGFR1OP2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:108564 FHL1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:116899 FKBP15    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:108826 GABPA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108893 GATA1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:108895 GATA3    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108896 GATA4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108897 GATA6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:108903 GBP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:109300 HBZ    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109304 HCFC1    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109315 HDAC1    BioGRID  PubMed Affinity Capture-Western; Negative Genetic; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:109316 HDAC2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:114368 HDAC3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:115106 HDAC4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:109338 HIF1A    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109341 HINT1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:112480 HLTF    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109402 HMGA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109414 HNF4A    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109467 HOXC11    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:109552 HSP90AA1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:109545 HSPA9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:109314 HTT    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:109654 IFI16    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:109769 IL1B    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:109928 JUN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:112927 KLF10    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:114726 KLF4    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112550 BioGRID:107711 KLF6    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:107152 KLF9    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:114384 LDB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:110191 LMO2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:110193 LMO7    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113574 LUZP1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:111580 MAPK1    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:107819 MAPK14    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111581 MAPK3    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:111585 MAPK8    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110368 MECP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110372 MEF2C    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:112550 BioGRID:110373 MEF2D    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:110376 MEIS2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110474 MNAT1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110593 MSX1    BioGRID  PubMed Affinity Capture-Western; Phenotypic Suppression 
    BioGRID:112550 BioGRID:110694 MYC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110698 MYCN    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:110713 MYH10    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112550 BioGRID:110714 MYH11    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:122884 MYH14    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:121681 MYH7B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110712 MYH9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:115871 MYL12A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110718 MYL3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:126617 MYL6B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:115670 MYL9    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110567 MYO1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110725 MYO1C    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110727 MYO1E    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110730 MYO6    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110737 MYOD1    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:110739 MYOG    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:110771 NCL    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:114973 NCOR1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:114974 NCOR2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:110783 NEB    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:110857 NFKB1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:110858 NFKB2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:110866 NFYA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:110867 NFYB    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110868 NFYC    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:110870 NGFR    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:112550 BioGRID:110888 NKX3-1    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:112956 NR2E1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:112883 NR2F1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:108792 NR5A1    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:110969 NTRK1    BioGRID  PubMed Affinity Capture-RNA 
    BioGRID:112550 BioGRID:111010 ODF2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:106652 PARP1    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:112550 BioGRID:111226 PFDN5    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111260 PGR    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:106894 PHOX2A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111355 PLEC    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:111384 PML    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112550 BioGRID:116745 POGZ    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:138656 POTEE    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:111447 POU2F1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:111464 PPARG    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:116059 PPP1R13L    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:111516 PPP2R4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111566 PRKCD    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western; Protein-peptide 
    BioGRID:112550 BioGRID:111576 PRKCZ    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity 
    BioGRID:112550 BioGRID:111577 PRKDC    BioGRID  PubMed Biochemical Activity 
    BioGRID:112550 BioGRID:116339 PSIP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:111678 PSMC5    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:111772 PURA    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111825 RAD51    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111849 RARA    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112550 BioGRID:111860 RB1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111863 RBBP4    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111868 RBL1    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111898 REL    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:111902 RELA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:111910 REST    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:111974 RNF4    BioGRID  PubMed Affinity Capture-Western; Biochemical Activity; Reconstituted Complex 
    BioGRID:112550 BioGRID:119724 RSF1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:112168 RXRA    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:112319 SFPQ    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:117439 SIN3A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:112393 SKP2    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:110262 SMAD2    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:110263 SMAD3    BioGRID  PubMed Affinity Capture-Luminescence; Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:110264 SMAD4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:112481 SMARCA4    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:112483 SMARCC1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:112485 SMARCC2    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:112550 SP1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:112553 SP3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:112554 SP4    BioGRID  PubMed Phenotypic Enhancement 
    BioGRID:112550 BioGRID:112598 SREBF1    BioGRID  PubMed Co-purification; Reconstituted Complex 
    BioGRID:112550 BioGRID:112599 SREBF2    BioGRID  PubMed Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:112600 SRF    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:119626 SRRT    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:112614 SRY    BioGRID  PubMed Co-localization 
    BioGRID:112550 BioGRID:112651 STAT3    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:116127 SUB1    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:113188 SUMO1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:112717 SYK    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:112737 TAF4    BioGRID  PubMed Affinity Capture-Western; Two-hybrid 
    BioGRID:112550 BioGRID:112749 TAL1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex; Two-hybrid 
    BioGRID:112550 BioGRID:112771 TBP    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:119027 TBX21    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:112881 TFAP4    BioGRID  PubMed Affinity Capture-MS; Affinity Capture-Western 
    BioGRID:112550 BioGRID:114428 TIMELESS    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:119030 TLX3    BioGRID  PubMed Two-hybrid 
    BioGRID:112550 BioGRID:114320 TNFRSF11A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113010 TP53    BioGRID  PubMed Affinity Capture-Western; Co-localization; Reconstituted Complex 
    BioGRID:112550 BioGRID:113021 TPM1    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113022 TPM2    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113023 TPM3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113024 TPM4    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113124 TTN    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:115651 TUBA1B    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:115654 TUBB3    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:115655 TUBB4A    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:65074 Taf4    BioGRID  PubMed Reconstituted Complex 
    BioGRID:112550 BioGRID:113164 UBC    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:113269 VHL    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:113272 VIM    BioGRID  PubMed Affinity Capture-MS 
    BioGRID:112550 BioGRID:113360 YY1    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 
    BioGRID:112550 BioGRID:119488 ZBTB7A    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:119242 ZBTB7B    BioGRID  PubMed Affinity Capture-Western 
    BioGRID:112550 BioGRID:1205541 tat    BioGRID  PubMed Affinity Capture-Western; Reconstituted Complex 

    Markers

    Genotypes

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    HMG box domain binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    RNA polymerase II repressing transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    bHLH transcription factor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		  
    enhancer binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone acetyltransferase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    histone deacetylase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    sequence-specific DNA binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    transcription regulatory region DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    cellular lipid metabolic process TAS
    Traceable Author Statement
    more info
    		  
    definitive hemopoiesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic camera-type eye morphogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic placenta development IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic process involved in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
    		  
    embryonic skeletal system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    enucleate erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    gene expression TAS
    Traceable Author Statement
    more info
    		  
    liver development IEA
    Inferred from Electronic Annotation
    more info
    		  
    lung development IEA
    Inferred from Electronic Annotation
    more info
    		  
    megakaryocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    ossification IEA
    Inferred from Electronic Annotation
    more info
    		  
    positive regulation by host of viral transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    positive regulation of transcription from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    positive regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    regulation of transcription, DNA-dependent IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    small molecule metabolic process TAS
    Traceable Author Statement
    more info
    		  
    transcription initiation from RNA polymerase II promoter TAS
    Traceable Author Statement
    more info
    		  
    transcription, DNA-dependent TAS
    Traceable Author Statement
    more info
    		  
    transforming growth factor beta receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    trophectodermal cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    virus-host interaction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    protein-DNA complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    Preferred Names
    transcription factor Sp1
    Names
    transcription factor Sp1
    specificity protein 1

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_030361.1 RefSeqGene

      Range
      5001..41252
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001251825.1 → NP_001238754.1  transcription factor Sp1 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC068889, AW028976, BC062539, FN908228
      UniProtKB/TrEMBL
      E4Z9M7
      UniProtKB/Swiss-Prot
      P08047
      Conserved Domains (2) summary
      pfam13465
      Location:624 – 647
      Blast Score: 127
      zf-H2C2_2; Zinc-finger double domain
      cl15478
      Location:640 – 660
      Blast Score: 95
      zf-C2H2; Zinc finger, C2H2 type

    2. NM_003109.1 → NP_003100.1  transcription factor Sp1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
      Source sequence(s)
      AC068889, AI561005, BC043224, BC062539
      Consensus CDS
      CCDS44898.1
      UniProtKB/TrEMBL
      G5E9M8
      UniProtKB/Swiss-Prot
      P08047
      Related
      ENSP00000404263, OTTHUMP00000242706, ENST00000426431, OTTHUMT00000407045
      Conserved Domains (3) summary
      COG5048
      Location:634 – 705
      Blast Score: 87
      COG5048; FOG: Zn-finger [General function prediction only]
      pfam13465
      Location:665 – 688
      Blast Score: 128
      zf-H2C2_2; Zinc-finger double domain
      cl15478
      Location:679 – 701
      Blast Score: 95
      zf-C2H2; Zinc finger, C2H2 type

    3. NM_138473.2 → NP_612482.2  transcription factor Sp1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AF255682, AI282745, AL442093, BC012008, BC043224, BF434304, BF436290, BF671559, BM463205, BQ072120, BQ431320, BQ774060, CD104746
      Consensus CDS
      CCDS8857.1
      UniProtKB/Swiss-Prot
      P08047
      Conserved Domains (2) summary
      pfam13465
      Location:672 – 695
      Blast Score: 128
      zf-H2C2_2; Zinc-finger double domain
      cl15478
      Location:686 – 708
      Blast Score: 94
      zf-C2H2; Zinc finger, C2H2 type

    RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 104

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh37.p10 Primary Assembly

    Genomic

    1. NC_000012.11 Reference GRCh37.p10 Primary Assembly

      Range
      53773979..53810230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate HuRef

    Genomic

    1. AC_000144.1 Alternate HuRef

      Range
      50814656..50850614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate CHM1_1.0

    Genomic

    1. NC_018923.1 Alternate CHM1_1.0

      Range
      53608185..53644432
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    genomic AB039286.1 BAB13476.1
    genomic ABBA01008331.1 None
    genomic ABBA01008332.1 None
    genomic ABBA01008333.1 None
    genomic ABBA01008334.1 None
    genomic ABBA01008335.1 None
    genomic ABBA01008336.1 None
    genomic ABBA01008337.1 None
    genomic AC068889.35 (35772..71429) None
    genomic AC073611.29 (105958..106551) None
    genomic AF255681.1 AAF78780.1
    genomic AF261690.1 AAF75063.1
    genomic AMYH01004479.1 (132548..132735) None
    genomic AMYH01004480.1 None
    genomic CH471054.1 EAW96698.1
      EAW96699.1
      EAW96700.1
    genomic CS691415.1 CAP12210.1
    mRNA AB209678.1 BAD92915.1
    mRNA AF252284.1 AAF67726.1
    mRNA AF255682.1 AAF78781.1
    mRNA AI282745.1 None
    mRNA AI561005.1 None
    mRNA AJ272134.1 CAB75345.1
    mRNA AK311995.1 BAG34933.1
    mRNA AL442093.1 None
    mRNA AW028976.1 None
    mRNA BC012008.1 None
    mRNA BC043224.1 AAH43224.1
    mRNA BC062539.1 AAH62539.1
    mRNA BC078158.1 None
    mRNA BF434304.1 None
    mRNA BF436290.1 None
    mRNA BF671559.1 None
    mRNA BM463205.1 None
    mRNA BQ072120.1 None
    mRNA BQ431320.1 None
    mRNA BQ774060.1 None
    mRNA CD104746.1 None
    mRNA FJ949572.1 ACR22508.1
    mRNA FN908228.1 CBM42955.1
    mRNA J03133.1 AAA61154.1
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08047.3 GenPept UniProtKB/Swiss-Prot:P08047

    Additional Links

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Medical
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous

      Supplemental Content

      Table of contents

      Related information

      • Order cDNA clone
        Order cDNA clone
      • 3D structures
        3D structure of a gene
      • BioAssay
        Related PubChem BioAssays
      • BioProjects
        BioProjects related to a gene
      • BioSystems
        BioSystems
      • CCDS
        Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
      • Conserved Domains
        Conserved Domain Database Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
      • dbVar
        Link from Gene to dbVar
      • EST
        Link to related EST entry
      • Full text in PMC
        PMC links
      • Full text in PMC_nucleotide
        Full text in PubMedCentral identified from shared sequence links
      • Genome
        Genome records having the gene annotated on corresponding genomic reference sequence.
      • GEO Profiles
        Related GEO
      • HomoloGene
        Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
      • Map Viewer
        These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
      • Nucleotide
        Link to related Nucleotide entry
      • OMIM
        Links between OMIM and Gene are calculated by Gene based on MIM numbers included in the summary and phenotype sections of the Gene record.
      • Probe
        Related Probe entry
      • Protein
        Link to related protein entry
      • PubChem Compound
        PubChem Compounds
      • PubChem Substance
        PubChem Substances
      • PubMed
        Links between Gene and PubMed are the result of the following: 1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required. 2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
      • PubMed (GeneRIF)
        GeneRIF -- Gene Reference Into Function Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well. http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
      • PubMed (OMIM)
        Links are provided when Gene has a link to a record in OMIM, and OMIM explicitly cites these publications in PubMed.
      • PubMed(nucleotide/PMC)
        Citations in PubMed identified from shared sequence and PMC links.
      • RefSeq Proteins
        Link to Protein RefSeqs
      • RefSeq RNAs
        Link to Nucleotide RefSeq RNAs
      • RefSeqGene
        Link to Nucleotide RefSeqGenes
      • SNP
        Related SNP records
      • SNP: GeneView
        SNPs linked from GeneView
      • SNP: Genotype
        Gene Genotype Report
      • SNP: VarView
        Related Clinical SNP
      • Taxonomy
        Link to related taxonomy entry
      • UniGene
        Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
      • UniSTS
        Related UniSTS records

      Links to other resources

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