Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information

SP1 Sp1 transcription factor [ Homo sapiens (human) ]

Gene ID: 6667, updated on 17-Apr-2014
Official Symbol
SP1provided by HGNC
Official Full Name
Sp1 transcription factorprovided by HGNC
Primary source
HGNC:11205
See related
Ensembl:ENSG00000185591; HPRD:01796; MIM:189906; Vega:OTTHUMG00000170047
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to GC-rich motifs of many promoters. The encoded protein is involved in many cellular processes, including cell differentiation, cell growth, apoptosis, immune responses, response to DNA damage, and chromatin remodeling. Post-translational modifications such as phosphorylation, acetylation, glycosylation, and proteolytic processing significantly affect the activity of this protein, which can be an activator or a repressor. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Location :
12q13.1
Sequence :
Chromosome: 12; NC_000012.12 (53380195..53416446)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene achalasia, adrenocortical insufficiency, alacrimia Neighboring gene Sp7 transcription factor Neighboring gene anti-Mullerian hormone receptor, type II Neighboring gene proline rich 13

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Protein interactions

Protein Gene Interaction Pubs
Tat, p14 tat Tat-induced IL-10 expression is regulated by p38 MAPK- and CaMK II-activated CREB-1 as well as Sp-1 transcription factors PubMed
tat Sp1 and Sp1-binding sites in the HIV-1 LTR promoter are required for HIV-1 Tat-mediated activation of viral transcription elongation PubMed
tat Sp1 synergizes with HIV-1 Tat to activate HIV-1 transcription PubMed
tat HIV-1 Tat expression inhibits the TCF-4-induced inhibition of Sp1 phosphorylation and Sp1-mediated HIV-1 LTR transcription PubMed
tat Hydroxyurea and IL-6 synergistically enhance HIV-1 Tat activation of HIV-1 LTR-driven transcription via the Sp1 binding site PubMed
tat HIV-1 Tat binds to DNA-PK and augments DNA-PK-mediated phosphorylation of Sp1 during Tat transactivation of the HIV-1 LTR promoter PubMed
tat HIV-1 Tat downregulates SOD2 expression by interacting with Sp1 and Sp3 to increase the Sp3-containing complexes on the basal SOD2 promoter PubMed
tat In hepatic cells, HIV-1 Tat expression upregulates Sp1 and Sp3, which play different roles in regulating MnSOD transcription (overexpression of Sp1 stimulates, while overexpression of Sp3 represses transcriptional activity) PubMed
tat HIV-1 Tat represses transcription from the MHC class I, MDR1, minimal SV40 and other Sp1-dependent promoters, indicating Tat downregulates expression from these promoters by inhibiting Sp1 function PubMed
tat HIV-1 Tat increases Sp1 binding in HeLa cells, suggesting Tat changes the conformation of Sp1 in order to regulate its function during HIV-1 transcription activation PubMed
tat Sp1, COUP-TF and HIV-1 Tat interact and cooperate in the transcriptional activation of the HIV-1 LTR promoter in human microglial cells PubMed
tat HIV-1 Tat upregulates the expression of galectin-3, NOS-3, and monocyte chemoattractant protein 1 (MCP-1) through Sp1 activation PubMed
tat YB-1 and Sp1 exert negative effects on each other's function in enhancing transcription from the HIV-1 promoter, suggesting an interplay between these two proteins during regulation of HIV-1 Tat function PubMed
tat The tumor suppressor protein p53 inhibits HIV-1 Tat-mediated transactivation of the HIV-1 LTR promoter through an interaction with the Sp1 sites in the LTR, suggesting an inhibition of Sp1 effects on Tat function PubMed
tat HIV-1 Tat amino acids 30-55 mediate binding of Tat to Sp1, an effect that some reports indicate is a direct binding interaction, while other reports suggest it is indirect and possibly mediated through interaction with other cellular factors PubMed
tat HIV-1 Tat cooperates with Sp1 to enhance transcript elongation, leading to exon skipping and effects on splicing PubMed
Vpr, p15 vpr HIV-1 Vpr induces HIF-1alpha expression, which involves the presence of Sp1 and the p65 subunit of NFkappaB transcription factors PubMed
vpr HIV-1 Vpr interacts with Sp1 in the context of an Sp1-DNA complex that may also include p53, resulting in the transactivation of the HIV-1 LTR promoter PubMed
vpr HIV-1 Vpr activates promoter activity of p21/Cip1/Waf1 through the GC-rich region located between nucleotides -84 and -74 in a manner that requires cooperativity of Sp1, which binds to the DNA sequence spanning -84 to -74 PubMed
vpr Results from GST pull-down assays show the association of Vpr with p53 in extracts containing Sp1, suggesting the physical interaction of Vpr with Sp1 and p53 could modulate transcriptional activity of p21 PubMed
nucleocapsid gag HIV-1 Nucleocapsid has been shown to bind to the HIV-1 LTR promoter and enhance NF-kappaB, Sp1, and TFIIB-induced HIV-1 LTR-directed RNA transcription PubMed

Go to the HIV-1, Human Protein Interaction Database

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
HMG box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II core promoter proximal region sequence-specific DNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II core promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II repressing transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
bHLH transcription factor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 
enhancer binding IEA
Inferred from Electronic Annotation
more info
 
histone acetyltransferase binding IEA
Inferred from Electronic Annotation
more info
 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
sequence-specific DNA binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular lipid metabolic process TAS
Traceable Author Statement
more info
 
definitive hemopoiesis IEA
Inferred from Electronic Annotation
more info
 
embryonic camera-type eye morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic placenta development IEA
Inferred from Electronic Annotation
more info
 
embryonic process involved in female pregnancy IEA
Inferred from Electronic Annotation
more info
 
embryonic skeletal system development IEA
Inferred from Electronic Annotation
more info
 
enucleate erythrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
gene expression TAS
Traceable Author Statement
more info
 
liver development IEA
Inferred from Electronic Annotation
more info
 
lung development IEA
Inferred from Electronic Annotation
more info
 
megakaryocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
ossification IEA
Inferred from Electronic Annotation
more info
 
positive regulation by host of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
small molecule metabolic process TAS
Traceable Author Statement
more info
 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
transcription, DNA-templated TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
trophectodermal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IC
Inferred by Curator
more info
PubMed 
protein-DNA complex IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
transcription factor Sp1
Names
transcription factor Sp1
specificity protein 1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030361.1 RefSeqGene

    Range
    5001..41252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251825.1NP_001238754.1  transcription factor Sp1 isoform c

    See proteins identical to NP_001238754.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (c) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC068889, AW028976, BC062539, FN908228
    UniProtKB/Swiss-Prot
    P08047
    Conserved Domains (3) summary
    COG5048
    Location:593664
    Blast Score: 102
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:638660
    Blast Score: 96
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:624647
    Blast Score: 123
    zf-H2C2_2; Zinc-finger double domain
  2. NM_003109.1NP_003100.1  transcription factor Sp1 isoform b

    See proteins identical to NP_003100.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform b has a shorter N-terminus, compared to isoform a.
    Source sequence(s)
    AC068889, AI561005, BC043224, BC062539
    Consensus CDS
    CCDS44898.1
    UniProtKB/Swiss-Prot
    P08047
    Related
    ENSP00000404263, OTTHUMP00000242706, ENST00000426431, OTTHUMT00000407045
    Conserved Domains (3) summary
    COG5048
    Location:634705
    Blast Score: 100
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:679701
    Blast Score: 96
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:665688
    Blast Score: 123
    zf-H2C2_2; Zinc-finger double domain
  3. NM_138473.2NP_612482.2  transcription factor Sp1 isoform a

    See proteins identical to NP_612482.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AF255682, AI282745, AL442093, BC012008, BC043224, BF434304, BF436290, BF671559, BM463205, BQ072120, BQ431320, BQ774060, CD104746
    Consensus CDS
    CCDS8857.1
    UniProtKB/Swiss-Prot
    P08047
    Conserved Domains (3) summary
    COG5048
    Location:641712
    Blast Score: 99
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:686708
    Blast Score: 96
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:672695
    Blast Score: 123
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38 Primary Assembly

Genomic

  1. NC_000012.12

    Range
    53380195..53416446
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006719570.1XP_006719633.1  

    Conserved Domains (3) summary
    COG5048
    Location:663734
    Blast Score: 96
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:708730
    Blast Score: 96
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:694717
    Blast Score: 123
    zf-H2C2_2; Zinc-finger double domain
  2. XM_006719571.1XP_006719634.1  

    Conserved Domains (3) summary
    COG5048
    Location:615686
    Blast Score: 99
    COG5048; FOG: Zn-finger [General function prediction only]
    pfam00096
    Location:660682
    Blast Score: 96
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:646669
    Blast Score: 123
    zf-H2C2_2; Zinc-finger double domain

Alternate HuRef

Genomic

  1. AC_000144.1 Alternate HuRef

    Range
    50814656..50850614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate CHM1_1.1

Genomic

  1. NC_018923.2 Alternate CHM1_1.1

    Range
    53741140..53777425
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Supplemental Content

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...