SYK spleen associated tyrosine kinase [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: SYKprovided by VGNC
Official Full Name: spleen associated tyrosine kinaseprovided by VGNC
Primary source: VGNC:VGNC:13975
Locus tag: CK820_G0036188
See related: Ensembl:ENSPTRG00000021098
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	11	NC_072409.2 (47605831..47700867, complement)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	9	NC_072407.1 (71167853..71265290)

Chromosome 11 - NC_072409.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

SHGC-153763 (e-PCR)
- UniSTS:177925

D10S275 (e-PCR)
- UniSTS:147992

RH48672 (e-PCR)
- UniSTS:43290

D8S2279 (e-PCR)
- UniSTS:473907

WI-18899 (e-PCR)
- UniSTS:28988

RH68079 (e-PCR)
- UniSTS:56400

RH120464 (e-PCR)
- UniSTS:133459

RH91425 (e-PCR)
- UniSTS:84312

D9S2062 (e-PCR)
- UniSTS:2175

RH69035 (e-PCR)
- UniSTS:21128

SYK-1 (e-PCR)
- UniSTS:513716

SYK_1884 (e-PCR)
- UniSTS:281037

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in B cell receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in macrophage activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil activation involved in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of B cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of alpha-beta T cell proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of cell adhesion mediated by integrin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of mast cell degranulation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of platelet aggregation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: tyrosine-protein kinase SYK

XP_016816608.1

EC 2.7.10.1

EC 2.7.10.2

XP_016816609.1

EC 2.7.10.1

EC 2.7.10.2

XP_016816610.1

EC 2.7.10.1

EC 2.7.10.2

XP_016816613.1

EC 2.7.10.1

EC 2.7.10.2

XP_063643750.1

EC 2.7.10.1

EC 2.7.10.2

XP_063643751.1

EC 2.7.10.1

EC 2.7.10.2

XP_063643752.1

EC 2.7.10.1

EC 2.7.10.2

XP_063643753.1

EC 2.7.10.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072409.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

47605831..47700867 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_016961119.4 → XP_016816608.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/TrEMBL

A0A2I3SCW8, A0A2J8KTF6, A0A6D2XLW6, H2QXF8

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_016961124.4 → XP_016816613.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A0A2I3RE67, A0A2J8KTF1, A0A6D2XTI9, H2QXF8

Related

ENSPTRP00000062965.1

Conserved Domains (3) summary

cd05116
Location:352 → 608

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_063787680.1 → XP_063643750.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/TrEMBL

A0A2I3SCW8, A0A2J8KTF6, A0A6D2XLW6, H2QXF8
XM_063787683.1 → XP_063643753.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A0A2I3RE67, A0A2J8KTF1, A0A6D2XTI9, H2QXF8
XM_016961121.4 → XP_016816610.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/TrEMBL

A0A2I3SCW8, A0A2J8KTF6, A0A6D2XLW6, H2QXF8

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_016961120.4 → XP_016816609.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/TrEMBL

A0A2I3SCW8, A0A2J8KTF6, A0A6D2XLW6, H2QXF8

Related

ENSPTRP00000074883.1

Conserved Domains (3) summary

cd05116
Location:375 → 631

PTKc_Syk; Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase

cd09938
Location:13 → 116

SH2_N-SH2_Zap70_Syk_like; N-terminal Src homology 2 (SH2) domain found in Zeta-chain-associated protein kinase 70 (ZAP-70) and Spleen tyrosine kinase (Syk) proteins

cd10401
Location:164 → 262

SH2_C-SH2_Syk_like; C-terminal Src homology 2 (SH2) domain found in Spleen tyrosine kinase (Syk) proteins
XM_063787682.1 → XP_063643752.1 tyrosine-protein kinase SYK isoform X2

UniProtKB/TrEMBL

A0A2I3RE67, A0A2J8KTF1, A0A6D2XTI9, H2QXF8
XM_063787681.1 → XP_063643751.1 tyrosine-protein kinase SYK isoform X1

UniProtKB/TrEMBL

A0A2I3SCW8, A0A2J8KTF6, A0A6D2XLW6, H2QXF8