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TWF2 twinfilin actin binding protein 2 [ Gallus gallus (chicken) ]

Gene ID: 415940, updated on 3-Apr-2024

Summary

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Symbol
TWF2provided by CGNC
Full Name
twinfilin actin binding protein 2provided by CGNC
Primary source
CGNC:50121
See related
Ensembl:ENSGALG00010027440
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
PTK9L
Orthologs
human mouse all
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Genomic context

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See TWF2 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
14
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (3129710..3148083, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (3179255..3197652, complement)

Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix protein 2-like Neighboring gene maestro heat-like repeat-containing protein family member 7 Neighboring gene HEAT repeat-containing protein 8 like 3 Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene microRNA let-7g Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M Neighboring gene WD repeat domain 82

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables actin monomer binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of neuron projection development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of lamellipodium assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sequestering of actin monomers IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in actin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in myofibril IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
twinfilin-2
Names
PTK9L protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001030589.2 → NP_001025760.2  twinfilin-2

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000252
    UniProtKB/Swiss-Prot
    Q5ZM35
    Related
    ENSGALP00010040740.1, ENSGALT00010066512.1
    Conserved Domains (2) summary
    cd11284
    Location:176 → 311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    3129710..3148083 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_040646193.2 → XP_040502127.1  twinfilin-2 isoform X4

    UniProtKB/TrEMBL
    A0A8V1AGP1
    Related
    ENSGALP00010040745.1, ENSGALT00010066520.1
    Conserved Domains (2) summary
    cd11284
    Location:239 → 374
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4 → 142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  2. XM_040646195.2 → XP_040502129.1  twinfilin-2 isoform X7

    UniProtKB/TrEMBL
    A0A8V1A992
    Related
    ENSGALP00010040741.1, ENSGALT00010066513.1
    Conserved Domains (2) summary
    cd11284
    Location:223 → 358
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  3. XM_015292836.3 → XP_015148322.2  twinfilin-2 isoform X6

    UniProtKB/TrEMBL
    A0A8V1A992
    Conserved Domains (2) summary
    cd11284
    Location:228 → 363
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  4. XM_015292835.3 → XP_015148321.2  twinfilin-2 isoform X5

    UniProtKB/TrEMBL
    A0A8V1A992
    Conserved Domains (2) summary
    cd11284
    Location:239 → 374
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  5. XM_015292834.3 → XP_015148320.2  twinfilin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8V1A992
    Conserved Domains (2) summary
    cd11284
    Location:250 → 385
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  6. XM_015292830.3 → XP_015148316.2  twinfilin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V1A992
    Conserved Domains (2) summary
    cd11284
    Location:286 → 421
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  7. XM_040646192.2 → XP_040502126.1  twinfilin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V1AGP1
    Conserved Domains (2) summary
    cd11284
    Location:270 → 405
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:39 → 173
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

  8. XM_040646196.2 → XP_040502130.1  twinfilin-2 isoform X8

    Conserved Domains (1) summary
    cd11285
    Location:53 → 189
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    3179255..3197652 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046926235.1 → XP_046782191.1  twinfilin-2 isoform X4

  2. XM_046926238.1 → XP_046782194.1  twinfilin-2 isoform X7

  3. XM_046926237.1 → XP_046782193.1  twinfilin-2 isoform X6

  4. XM_046926236.1 → XP_046782192.1  twinfilin-2 isoform X5

  5. XM_046926234.1 → XP_046782190.1  twinfilin-2 isoform X3

  6. XM_046926232.1 → XP_046782188.1  twinfilin-2 isoform X1

  7. XM_046926233.1 → XP_046782189.1  twinfilin-2 isoform X2

  8. XM_046926239.1 → XP_046782195.1  twinfilin-2 isoform X9

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ZM35.1 GenPept UniProtKB/Swiss-Prot:Q5ZM35

Gene LinkOut

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