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Twf2 twinfilin actin binding protein 2 [ Mus musculus (house mouse) ]

Gene ID: 23999, updated on 9-May-2024

Summary

Official Symbol
Twf2provided by MGI
Official Full Name
twinfilin actin binding protein 2provided by MGI
Primary source
MGI:MGI:1346078
See related
Ensembl:ENSMUSG00000023277 AllianceGenome:MGI:1346078
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Ptk9l; Ptk9r; A6-related
Summary
Enables actin monomer binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in barbed-end actin filament capping and sequestering of actin monomers. Located in several cellular components, including lamellipodium; myofibril; and stereocilium. Is expressed in several structures, including ear; early embryo; genitourinary system; nervous system; and respiratory system. Orthologous to human TWF2 (twinfilin actin binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart adult (RPKM 69.7), thymus adult (RPKM 44.4) and 27 other tissues See more
Orthologs
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Genomic context

See Twf2 in Genome Data Viewer
Location:
9 F1; 9 57.46 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106080307..106092586)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106203108..106215387)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene WD repeat domain containing 82 Neighboring gene microRNA let7g Neighboring gene protein phosphatase 1M Neighboring gene STARR-positive B cell enhancer ABC_E8312 Neighboring gene STARR-positive B cell enhancer ABC_E5101 Neighboring gene STARR-positive B cell enhancer ABC_E10582 Neighboring gene toll-like receptor 9 Neighboring gene aminolevulinic acid synthase 1 Neighboring gene RIKEN cDNA 4930500F10 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (1) 
  • Targeted (3)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
PubMed 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables actin monomer binding IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in barbed-end actin filament capping IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to retinoic acid ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of axon extension ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of microvillus length IC
Inferred by Curator
more info
PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sequestering of actin monomers IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in filopodium IDA
Inferred from Direct Assay
more info
PubMed 
located_in growth cone ISO
Inferred from Sequence Orthology
more info
 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in myofibril IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in stereocilium IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
twinfilin-2
Names
PTK9 protein typrotein tyrosine kinase 9-like (A6-related protein)
mA6RP
protein tyrosine kinase 9 related protein
protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2
twinfilin-1-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011876.3NP_036006.1  twinfilin-2

    See identical proteins and their annotated locations for NP_036006.1

    Status: PROVISIONAL

    Source sequence(s)
    AC164430
    Consensus CDS
    CCDS23473.1
    UniProtKB/Swiss-Prot
    Q3TD06, Q3TZG2, Q8BN77, Q9DCK8, Q9Z0P5
    Related
    ENSMUSP00000024047.6, ENSMUST00000024047.12
    Conserved Domains (2) summary
    cd11284
    Location:176311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106080307..106092586
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)