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TWF2 twinfilin actin binding protein 2 [ Homo sapiens (human) ]

Gene ID: 11344, updated on 2-Oct-2018

Summary

Official Symbol
TWF2provided by HGNC
Official Full Name
twinfilin actin binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9621
See related
Ensembl:ENSG00000247596 MIM:607433; Vega:OTTHUMG00000158105
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A6r; A6RP; PTK9L; MSTP011
Summary
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 28.1), heart (RPKM 27.1) and 25 other tissues See more
Orthologs

Genomic context

See TWF2 in Genome Data Viewer
Location:
3p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (52228610..52239167, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52262626..52273183, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene toll like receptor 9 Neighboring gene uncharacterized LOC101929054 Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
NHGRI GWA Catalog
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TLR9

Homology

Clone Names

  • FLJ56277

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA binding HDA PubMed 
actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
actin monomer binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cadherin binding HDA PubMed 
phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
barbed-end actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
cell projection organization IEA
Inferred from Electronic Annotation
more info
 
cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of microvillus length IC
Inferred by Curator
more info
PubMed 
sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sequestering of actin monomers ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
extracellular exosome HDA PubMed 
filopodium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
growth cone IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myofibril ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
stereocilium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
twinfilin-2
Names
A6-related protein
PTK9L protein tyrosine kinase 9-like (A6-related protein)
protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2
twinfilin-1-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007284.3NP_009215.1  twinfilin-2

    See identical proteins and their annotated locations for NP_009215.1

    Status: REVIEWED

    Source sequence(s)
    AL136773, BC003161, BI551353
    Consensus CDS
    CCDS2849.1
    UniProtKB/Swiss-Prot
    Q6IBS0
    Related
    ENSP00000303908.4, OTTHUMP00000212615, ENST00000305533.9, OTTHUMT00000350199
    Conserved Domains (2) summary
    cd11284
    Location:176311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    52228610..52239167 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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