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TWF2 twinfilin actin binding protein 2 [ Homo sapiens (human) ]

Gene ID: 11344, updated on 4-Jul-2021

Summary

Official Symbol
TWF2provided by HGNC
Official Full Name
twinfilin actin binding protein 2provided by HGNC
Primary source
HGNC:HGNC:9621
See related
Ensembl:ENSG00000247596 MIM:607433
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A6r; A6RP; PTK9L; MSTP011
Summary
The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in lymph node (RPKM 28.1), heart (RPKM 27.1) and 25 other tissues See more
Orthologs
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Genomic context

See TWF2 in Genome Data Viewer
Location:
3p21.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (52228612..52239158, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52262628..52273174, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 5'-aminolevulinate synthase 1 Neighboring gene Sharpr-MPRA regulatory region 10522 Neighboring gene toll like receptor 9 Neighboring gene TWF2 divergent transcript Neighboring gene protein phosphatase, Mg2+/Mn2+ dependent 1M

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: TLR9

Homology

Clone Names

  • FLJ56277

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables RNA binding HDA PubMed 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables actin monomer binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables cadherin binding HDA PubMed 
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament depolymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in barbed-end actin filament capping ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to growth factor stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to retinoic acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of axon extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lamellipodium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of microvillus length IC
Inferred by Curator
more info
PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sequestering of actin monomers ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in filopodium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
PubMed 
located_in lamellipodium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in myofibril IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in myofibril ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in stereocilium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
twinfilin-2
Names
A6-related protein
PTK9L protein tyrosine kinase 9-like (A6-related protein)
protein tyrosine kinase 9-like (A6-related protein)
twinfilin, actin-binding protein, homolog 2
twinfilin-1-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007284.4NP_009215.1  twinfilin-2

    See identical proteins and their annotated locations for NP_009215.1

    Status: REVIEWED

    Source sequence(s)
    AL136773, BC003161, BI551353
    Consensus CDS
    CCDS2849.1
    UniProtKB/Swiss-Prot
    Q6IBS0
    Related
    ENSP00000303908.4, ENST00000305533.10
    Conserved Domains (2) summary
    cd11284
    Location:176311
    ADF_Twf-C_like; C-terminal ADF domain of twinfilin and related proteins
    cd11285
    Location:4142
    ADF_Twf-N_like; N-terminal ADF domain of twinfilin and related proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    52228612..52239158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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