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NCAPH non-SMC condensin I complex subunit H [ Homo sapiens (human) ]

Gene ID: 23397, updated on 26-May-2016
Official Symbol
NCAPHprovided by HGNC
Official Full Name
non-SMC condensin I complex subunit Hprovided by HGNC
Primary source
HGNC:HGNC:1112
See related
Ensembl:ENSG00000121152 HPRD:03820; MIM:602332; Vega:OTTHUMG00000130451
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BRRN1; CAP-H
Summary
This gene encodes a member of the barr gene family and a regulatory subunit of the condensin complex. This complex is required for the conversion of interphase chromatin into condensed chromosomes. The protein encoded by this gene is associated with mitotic chromosomes, except during the early phase of chromosome condensation. During interphase, the protein has a distinct punctate nucleolar localization. Alternatively spliced transcript variants encoding different proteins have been described. [provided by RefSeq, Jul 2013]
Orthologs
Location:
2q11.2
Exon count:
18
Annotation release Status Assembly Chr Location
107 current GRCh38.p2 (GCF_000001405.28) 2 NC_000002.12 (96335741..96377095)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97001479..97042833)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373495 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein-like 1 Neighboring gene neuralized E3 ubiquitin protein ligase 3 Neighboring gene uncharacterized LOC105373496

Protein interactions

Protein Gene Interaction Pubs
Tat tat Interaction of HIV-1 Tat with CAPH in T-cells is identified by a proteomic strategy based on affinity chromatography coupled with mass spectrometry PubMed

Go to the HIV-1, Human Interaction Database

  • Aurora B signaling, organism-specific biosystem (from Pathway Interaction Database)
    Aurora B signaling, organism-specific biosystem
    Aurora B signaling
  • Cell Cycle, organism-specific biosystem (from REACTOME)
    Cell Cycle, organism-specific biosystem
    Cell Cycle
  • Cell Cycle, Mitotic, organism-specific biosystem (from REACTOME)
    Cell Cycle, Mitotic, organism-specific biosystemThe replication of the genome and the subsequent segregation of chromosomes into daughter cells are controlled by a series of events collectively known as the cell cycle. DNA replication is carried o...
  • Condensation of Prometaphase Chromosomes, organism-specific biosystem (from REACTOME)
    Condensation of Prometaphase Chromosomes, organism-specific biosystemThe condensin I complex is evolutionarily conserved and consists of five subunits: two SMC (structural maintenance of chromosomes) family subunits, SMC2 and SMC4, and three non-SMC subunits, NCAPD2, ...
  • M Phase, organism-specific biosystem (from REACTOME)
    M Phase, organism-specific biosystemMitosis, or the M phase, involves nuclear division and cytokinesis, where two identical daughter cells are produced. Mitosis involves prophase, prometaphase, metaphase, anaphase, and telophase. Fin...
  • Mitotic Prometaphase, organism-specific biosystem (from REACTOME)
    Mitotic Prometaphase, organism-specific biosystemThe dissolution of the nuclear membrane marks the beginning of the prometaphase. Kinetochores are created when proteins attach to the centromeres. Microtubules then attach at the kinetochores, and th...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell division IEA
Inferred from Electronic Annotation
more info
 
mitotic chromosome condensation IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
condensin complex subunit 2
Names
barren homolog 1
chromosome-associated protein H
non-SMC condensin I complex, subunit H

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001281710.1NP_001268639.1  condensin complex subunit 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC021188, AK308050, D38553
    UniProtKB/Swiss-Prot
    Q15003
    Conserved Domains (1) summary
    pfam05786
    Location:26729
    Cnd2; Condensin complex subunit 2
  2. NM_001281711.1NP_001268640.1  condensin complex subunit 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC021188, AK299248, D38553
    UniProtKB/Swiss-Prot
    Q15003
    UniProtKB/TrEMBL
    B4DRG7
    Conserved Domains (1) summary
    pfam05786
    Location:13716
    Cnd2; Condensin complex subunit 2
  3. NM_001281712.1NP_001268641.1  condensin complex subunit 2 isoform 4

    See identical proteins and their annotated locations for NP_001268641.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the coding region and initiates translation at an alternate start codon compared to variant 1. The resulting protein (isoform 4) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC021188, AK303725
    Consensus CDS
    CCDS62960.1
    UniProtKB/Swiss-Prot
    Q15003
    Related
    ENSP00000400774, OTTHUMP00000207475, ENST00000427946, OTTHUMT00000338872
    Conserved Domains (1) summary
    cl19886
    Location:1604
    Cnd2; Condensin complex subunit 2
  4. NM_015341.4NP_056156.2  condensin complex subunit 2 isoform 1

    See identical proteins and their annotated locations for NP_056156.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
    Source sequence(s)
    AC021188, D38553
    Consensus CDS
    CCDS2021.1
    UniProtKB/Swiss-Prot
    Q15003
    Related
    ENSP00000240423, OTTHUMP00000161008, ENST00000240423, OTTHUMT00000252842
    Conserved Domains (1) summary
    pfam05786
    Location:37740
    Cnd2; Condensin complex subunit 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 107 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p2 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p2 Primary Assembly

    Range
    96335741..96377095
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712388.2XP_006712451.1  

    Related
    ENSP00000407308, OTTHUMP00000207477, ENST00000455200, OTTHUMT00000338875
    Conserved Domains (1) summary
    pfam05786
    Location:37709
    Cnd2; Condensin complex subunit 2
  2. XM_005263908.2XP_005263965.1  

    Related
    ENSP00000405237, OTTHUMP00000207476, ENST00000435975, OTTHUMT00000338874
    Conserved Domains (1) summary
    pfam05786
    Location:37722
    Cnd2; Condensin complex subunit 2

Alternate CHM1_1.1

Genomic

  1. NC_018913.2 Alternate CHM1_1.1

    Range
    97005816..97047166
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)