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Ncaph non-SMC condensin I complex, subunit H [ Mus musculus (house mouse) ]

Gene ID: 215387, updated on 8-Feb-2024

Summary

Official Symbol
Ncaphprovided by MGI
Official Full Name
non-SMC condensin I complex, subunit Hprovided by MGI
Primary source
MGI:MGI:2444777
See related
Ensembl:ENSMUSG00000034906 AllianceGenome:MGI:2444777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Brrn1; CAP-H; HCAP-H; mCAP-H; A730011O11Rik
Summary
Enables chromatin binding activity. Involved in female meiosis chromosome separation. Acts upstream of or within meiotic chromosome condensation and meiotic chromosome segregation. Located in nucleus. Part of condensin complex. Is active in chromosome. Is expressed in midbrain ventricular layer; nephrogenic zone; olfactory cortex ventricular layer; and telencephalon ventricular layer. Human ortholog(s) of this gene implicated in primary autosomal recessive microcephaly. Orthologous to human NCAPH (non-SMC condensin I complex subunit H). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E11.5 (RPKM 23.0), liver E14 (RPKM 21.6) and 10 other tissues See more
Orthologs
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Genomic context

See Ncaph in Genome Data Viewer
Location:
2 F1; 2 61.76 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126945729..126975857, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (127103809..127133954, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene biliverdin reductase A Neighboring gene predicted gene, 31414 Neighboring gene predicted gene, 39922 Neighboring gene STARR-positive B cell enhancer ABC_E3400 Neighboring gene STARR-seq mESC enhancer starr_05620 Neighboring gene predicted gene, 35347 Neighboring gene inositol 1,4,5-triphosphate receptor interacting protein-like 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0074, MGC38424

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in chromosome IGI
Inferred from Genetic Interaction
more info
PubMed 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of condensin complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of condensin complex ISO
Inferred from Sequence Orthology
more info
 
part_of condensin complex NAS
Non-traceable Author Statement
more info
PubMed 
part_of condensin complex TAS
Traceable Author Statement
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
condensin complex subunit 2
Names
XCAP-H homolog
barren homolog protein 1
chromosome-associated protein H

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144818.4NP_659067.2  condensin complex subunit 2

    See identical proteins and their annotated locations for NP_659067.2

    Status: VALIDATED

    Source sequence(s)
    AL928590
    Consensus CDS
    CCDS16693.2
    UniProtKB/Swiss-Prot
    Q8BY01, Q8C156, Q8VDM9
    UniProtKB/TrEMBL
    Q6ZQJ9
    Related
    ENSMUSP00000106017.4, ENSMUST00000110387.4
    Conserved Domains (1) summary
    pfam05786
    Location:42727
    Cnd2; Condensin complex subunit 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    126945729..126975857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)