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SHANK2 SH3 and multiple ankyrin repeat domains 2 [ Bos indicus (zebu cattle) ]

Gene ID: 109554568, updated on 14-Mar-2024

Summary

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Gene symbol
SHANK2
Gene description
SH3 and multiple ankyrin repeat domains 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Bos indicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 29
Exon count:
24
Annotation release Status Assembly Chr Location
100 current Bos_indicus_1.0 (GCF_000247795.1) 29 NC_032678.1 (49519281..50051705, complement)

Chromosome 29 - NC_032678.1Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene cortactin Neighboring gene NAD synthetase 1 Neighboring gene 7-dehydrocholesterol reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_032678.1 Chromosome 29 Reference Bos_indicus_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ionotropic glutamate receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables synaptic receptor adaptor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
SH3 and multiple ankyrin repeat domains protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Bos indicus Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Bos_indicus_1.0 Primary Assembly

Genomic

  1. NC_032678.1 Reference Bos_indicus_1.0 Primary Assembly

    Range
    49519281..50051705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_019955163.1 → XP_019810722.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

    UniProtKB/TrEMBL
    A0A6P5BDN0
    Conserved Domains (7) summary
    cd09506
    Location:1763 → 1828
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:258 → 383
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:623 → 716
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:263 → 295
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:168 → 243
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:57 → 140
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:528 → 579
    SH3; Src Homology 3 domain superfamily

  2. XM_019955161.1 → XP_019810720.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A6P5BKK8
    Conserved Domains (8) summary
    cd09506
    Location:1793 → 1858
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:258 → 383
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:680 → 773
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:263 → 295
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:168 → 243
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:57 → 140
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:585 → 636
    SH3; Src Homology 3 domain superfamily
    cl26464
    Location:891 → 1497
    Atrophin-1; Atrophin-1 family

  3. XM_019955159.1 → XP_019810718.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A6P5BKK7
    Conserved Domains (7) summary
    cd09506
    Location:1820 → 1885
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:258 → 383
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:680 → 773
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:263 → 295
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:168 → 243
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:57 → 140
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:585 → 636
    SH3; Src Homology 3 domain superfamily

  4. XM_019955160.1 → XP_019810719.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A6P5BKK7
    Conserved Domains (7) summary
    cd09506
    Location:1820 → 1885
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd00204
    Location:258 → 383
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd00992
    Location:680 → 773
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    sd00045
    Location:263 → 295
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:168 → 243
    Ank_2; Ankyrin repeats (3 copies)
    pfam16511
    Location:57 → 140
    FERM_f0; N-terminal or F0 domain of Talin-head FERM
    cl17036
    Location:585 → 636
    SH3; Src Homology 3 domain superfamily
Nucleotide Protein
Heading Accession and Version

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