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SHANK2 SH3 and multiple ankyrin repeat domains 2 [ Homo sapiens (human) ]

Gene ID: 22941, updated on 17-Jun-2024

Summary

Official Symbol
SHANK2provided by HGNC
Official Full Name
SH3 and multiple ankyrin repeat domains 2provided by HGNC
Primary source
HGNC:HGNC:14295
See related
Ensembl:ENSG00000162105 MIM:603290; AllianceGenome:HGNC:14295
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SHANK; AUTS17; CORTBP1; CTTNBP1; ProSAP1; SPANK-3
Summary
This gene encodes a protein that is a member of the Shank family of synaptic proteins that may function as molecular scaffolds in the postsynaptic density of excitatory synapses. Shank proteins contain multiple domains for protein-protein interaction, including ankyrin repeats, and an SH3 domain. This particular family member contains a PDZ domain, a consensus sequence for cortactin SH3 domain-binding peptides and a sterile alpha motif. The alternative splicing demonstrated in Shank genes has been suggested as a mechanism for regulating the molecular structure of Shank and the spectrum of Shank-interacting proteins in the postsynaptic densities of the adult and developing brain. Alterations in the encoded protein may be associated with susceptibility to autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Broad expression in brain (RPKM 4.2), kidney (RPKM 2.6) and 18 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See SHANK2 in Genome Data Viewer
Location:
11q13.3-q13.4
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (70467854..71253228, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (70488279..71179617, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (70313959..70963623, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene PTPRF interacting protein alpha 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70230466-70230972 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:70235067-70235838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70235839-70236608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70237380-70238149 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70242965-70243153 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5162 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3702 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3703 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3704 Neighboring gene Sharpr-MPRA regulatory region 1776 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70250285-70250464 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70261331-70261532 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:70265651-70266850 Neighboring gene CTTN divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70289993-70290826 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3705 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70343973-70344473 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70346781-70346940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70351607-70352106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70364325-70364826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70371409-70372366 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70370453-70371408 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70369495-70370452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70373323-70374279 Neighboring gene cortactin Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70384621-70385240 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70385241-70385858 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70390839-70391673 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70392509-70393343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70393780-70394730 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70397475-70397990 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr11:70399135-70400334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70404151-70404881 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70403420-70404150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70422686-70423186 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70423187-70423687 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70425215-70425716 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70428716-70429218 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429219-70429720 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70429721-70430223 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70430775-70431315 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70457727-70458490 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70464553-70465368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70465369-70466183 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70483308-70484149 Neighboring gene Sharpr-MPRA regulatory region 3810 Neighboring gene SHANK2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70508534-70509208 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70509209-70509883 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70516085-70516612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70519247-70519774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70527253-70528017 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70526489-70527252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70533609-70534130 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70534131-70534652 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70555908-70556529 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70559535-70560424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70560938-70561770 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70563993-70564502 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:70565347-70565550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70585495-70586046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70586047-70586598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70591157-70591852 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70591853-70592548 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70592549-70593244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70614429-70614930 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:70634290-70635489 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70680550-70681124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70681125-70681698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70681699-70682272 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70686259-70686758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70732137-70732636 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70737866-70738791 Neighboring gene SHANK2 antisense RNA 3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70751855-70752356 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70752357-70752856 Neighboring gene microRNA 3664 Neighboring gene MPRA-validated peak1330 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70819961-70820462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70820463-70820962 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70850430-70851309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70851310-70852188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70909445-70910320 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70910321-70911195 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70916186-70916782 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:70916783-70917377 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70925881-70926462 Neighboring gene Sharpr-MPRA regulatory region 1844 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70955112-70955856 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70955857-70956600 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70956601-70957344 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:70957345-70958088 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:70979141-70979640 Neighboring gene uncharacterized LOC124902706 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:71009949-71011148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:71012233-71012890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5165 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71054609-71055108 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3706 Neighboring gene actin, aortic smooth muscle-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71100061-71100562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71100563-71101062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71107588-71108289 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71110671-71111514 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:71113580-71114080 Neighboring gene actin epsilon 1, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Autism spectrum disorder
MedGen: C1510586 GeneReviews: Not available
Compare labs
Autism, susceptibility to, 17
MedGen: C3150693 OMIM: 613436 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated 2023-10-26)

ClinGen Genome Curation PagePubMed
Triplosensitivity

No evidence available (Last evaluated 2023-10-26)

ClinGen Genome Curation Page

EBI GWAS Catalog

Description
A genome-wide association study of recipient genotype and medium-term kidney allograft function.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
 
enables ionotropic glutamate receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ionotropic glutamate receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of postsynaptic density IEA
Inferred from Electronic Annotation
more info
 
enables synaptic receptor adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables synaptic receptor adaptor activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in adult behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adult locomotory behavior IEA
Inferred from Electronic Annotation
more info
 
involved_in associative learning IEA
Inferred from Electronic Annotation
more info
 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in long-term synaptic depression ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in long-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in maintenance of postsynaptic density structure IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
involved_in response to nutrient IEA
Inferred from Electronic Annotation
more info
 
involved_in response to xenobiotic stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in vocalization behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in cellular_component ND
No biological Data available
more info
 
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
is_active_in dendritic spine IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in dendritic spine ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in growth cone ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with neurofilament ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in photoreceptor inner segment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in photoreceptor outer segment ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
colocalizes_with postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
colocalizes_with postsynaptic membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in presynaptic active zone IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
SH3 and multiple ankyrin repeat domains protein 2
Names
GKAP/SAPAP interacting protein
cortactin SH3 domain-binding protein
cortactin-binding protein 1
proline-rich synapse associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042866.2 RefSeqGene

    Range
    5651..690374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001379226.1NP_001366155.1  SH3 and multiple ankyrin repeat domains protein 2 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AP000590, AP001271, AP003783
    Consensus CDS
    CCDS91527.1
    UniProtKB/TrEMBL
    A6NHU9, C0SPH0
    Related
    ENSP00000499561.1, ENST00000656230.1
    Conserved Domains (4) summary
    cd09506
    Location:14031468
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:150201
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    cd00992
    Location:245338
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR00600
    Location:9101122
    rad2; DNA excision repair protein (rad2)
  2. NM_012309.5NP_036441.2  SH3 and multiple ankyrin repeat domains protein 2 isoform 1

    See identical proteins and their annotated locations for NP_036441.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC234421, AP000590, AP001271, AP003783, AP004370, AP005401
    UniProtKB/Swiss-Prot
    C0SPG8, C0SPG9, Q3Y8G9, Q52LK2, Q9UKP1, Q9UPX8
    Related
    ENSP00000469689.2, ENST00000601538.6
    Conserved Domains (8) summary
    cd09506
    Location:17821847
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:529580
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    COG0666
    Location:201365
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00992
    Location:624717
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR00600
    Location:12891501
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:230261
    ANK; ANK repeat [structural motif]
    cd17176
    Location:55142
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
    pfam12796
    Location:335398
    Ank_2; Ankyrin repeats (3 copies)
  3. NM_133266.5NP_573573.2  SH3 and multiple ankyrin repeat domains protein 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in its 5' UTR, lacks a portion of the 5' coding region, and uses an alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AP000590, AP001271
    UniProtKB/TrEMBL
    A6NHU9, C0SPH0
    Related
    ENSP00000345193.7, ENST00000338508.9
    Conserved Domains (3) summary
    cd09506
    Location:11941259
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    smart00454
    Location:11951261
    SAM; Sterile alpha motif
    cd00992
    Location:36129
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

RNA

  1. NR_110766.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site at an internal exon and lacks two internal exons, compared to variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    AP000590, AP001271

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    70467854..71253228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047426616.1XP_047282572.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  2. XM_047426618.1XP_047282574.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  3. XM_047426614.1XP_047282570.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  4. XM_047426619.1XP_047282575.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

  5. XM_047426611.1XP_047282567.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  6. XM_017017389.2XP_016872878.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X2

  7. XM_047426620.1XP_047282576.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

  8. XM_047426612.1XP_047282568.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  9. XM_047426615.1XP_047282571.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  10. XM_047426613.1XP_047282569.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  11. XM_047426617.1XP_047282573.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  12. XM_017017388.2XP_016872877.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

    UniProtKB/Swiss-Prot
    C0SPG8, C0SPG9, Q3Y8G9, Q52LK2, Q9UKP1, Q9UPX8
    Conserved Domains (8) summary
    cd09506
    Location:17821847
    SAM_Shank1,2,3; SAM domain of Shank1,2,3 family proteins
    cd11983
    Location:529580
    SH3_Shank2; Src homology 3 domain of SH3 and multiple ankyrin repeat domains protein 2
    COG0666
    Location:201365
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00992
    Location:624717
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR00600
    Location:12891501
    rad2; DNA excision repair protein (rad2)
    sd00045
    Location:230261
    ANK; ANK repeat [structural motif]
    cd17176
    Location:55142
    FERM_F0_SHANK2; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F0 sub-domain, found in SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)
    pfam12796
    Location:335398
    Ank_2; Ankyrin repeats (3 copies)
  13. XM_047426622.1XP_047282578.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EUA2
  14. XM_047426621.1XP_047282577.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X5

    UniProtKB/TrEMBL
    E7EUA2
  15. XM_017017390.2XP_016872879.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A590UJ45, A6NHU9, C0SPH0
    Related
    ENSP00000499270.1, ENST00000659264.1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    70488279..71179617 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054368112.1XP_054224087.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  2. XM_054368114.1XP_054224089.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  3. XM_054368110.1XP_054224085.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  4. XM_054368115.1XP_054224090.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

  5. XM_054368107.1XP_054224082.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  6. XM_054368106.1XP_054224081.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X2

  7. XM_054368116.1XP_054224091.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X4

  8. XM_054368108.1XP_054224083.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  9. XM_054368111.1XP_054224086.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  10. XM_054368109.1XP_054224084.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  11. XM_054368105.1XP_054224080.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X1

    UniProtKB/Swiss-Prot
    C0SPG8, C0SPG9, Q3Y8G9, Q52LK2, Q9UKP1, Q9UPX8
  12. XM_054368113.1XP_054224088.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X3

  13. XM_054368118.1XP_054224093.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X6

    UniProtKB/TrEMBL
    E7EUA2
  14. XM_054368117.1XP_054224092.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X5

    UniProtKB/TrEMBL
    E7EUA2
  15. XM_054368119.1XP_054224094.1  SH3 and multiple ankyrin repeat domains protein 2 isoform X7

    UniProtKB/TrEMBL
    A0A590UJ45, A6NHU9, C0SPH0