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cd00204: ANK 
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ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other types of domains. The structural repeat unit contains two antiparallel helices and a beta-hairpin, repeats are stacked in a superhelical arrangement; this alignment contains 4 consecutive repeats.
Links
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Statistics
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PSSM-Id: 238125
View PSSM: cd00204
Aligned: 342 rows
Threshold Bit Score: 38.5187
Threshold Setting Gi: 137552
Created: 24-May-2001
Updated: 17-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
Hierarchy
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cd00204 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd00204 is a member of the superfamily cl19088.
cd00204:ANK123522123522137552465059118141013755246505930970443213793213793096970309703913748630970491375433097049465059309704913754318086121808604117253514217321421732731771123597814625169123522999072999072118141045708046505930970441808606180860695379569137486321379180861430970493097039391941193165410455721820303818203107332693210455723097050257093315487294314270074859233152662387453660417769537956912359787705748145738512914017157182062914017157182063876657332314938746211SW6 A165185162257622579802990142015218086252492902387391160417769569137486332314943357003504025709333875319140238314270033269322588630360003072999518086253874028663402575085629802990956916216091148702739158213438031162081738046422447952244796291401733231493287188332314935040311620821306281148701570381083545643427836000301457385195379569140238116310311814931022831170833112359781428560116216091820224895379569956972912799569332314933231491199016857785128492777508562119907791231419512854491128552261199013879156387915614091952141332473879156387915638791563879156135620946041776212072038813443876763140919521354223016081347113640425703511738038711730901262743919413874536172347217237524127229287865584741116310311778723881344100299512084994117221822931122225997151464921049087294199485016874965772506381304686738745361138841814196175426981168457175426941754269817864166113884170331055708455708417033107295202557084170331017033101127693597900811794076015040387301236107267221794075838742032707268143493476330383881344108685838742031AWC B6279474507613140766375093151840139387815514285601387665738781551293079364184543357003876657387665738815509537956912359787288211420152332942774648154998613431606328718838745361175522675384038803193927831136260733201223320122145307042244796748592314530704224479538813446240551135996062405639278311434934724929001442401911359960144240191697549629140171094471860417761442401914731297728821117537315241327388031914349347144240194335700751257110719883179782561IKN D3454763874621750581614424019287865765723829056163641845152329911324261399733711AP7  1G3N B1K1B A1213987288591580792011814934335700327330775058161DCQ A12139812627432871883880319388134410868583493527237339525703513873911157182061820311310029951419543324471243880319291401729140171723472172375215341604750310024929026580519387676317998549270726828294352829435328718880522331786287814731279123522123522137552465059118141013755246505930970443213793213793096970309703913748630970491375433097049465059309704913754318086121808604117253514217321421732731771123597814625169123522999072999072118141045708046505930970441808606180860695379569137486321379180861430970493097039391941193165410455721820303818203107332693210455723097050257093315487294314270074859233152662387453660417769537956912359787705748145738512914017157182062914017157182063876657332314938746211SW6 A165185162257622579802990142015218086252492902387391160417769569137486332314943357003504025709333875319140238314270033269322588630360003072999518086253874028663402575085629802990956916216091148702739158213438031162081738046422447952244796291401733231493287188332314935040311620821306281148701570381083545643427836000301457385195379569140238116310311814931022831170833112359781428560116216091820224895379569956972912799569332314933231491199016857785128492777508562119907791231419512854491128552261199013879156387915614091952141332473879156387915638791563879156135620946041776212072038813443876763140919521354223016081347113640425703511738038711730901262743919413874536172347217237524127229287865584741116310311778723881344100299512084994117221822931122225997151464921049087294199485016874965772506381304686738745361138841814196175426981168457175426941754269817864166113884170331055708455708417033107295202557084170331017033101127693597900811794076015040387301236107267221794075838742032707268143493476330383881344108685838742031AWC B6279474507613140766375093151840139387815514285601387665738781551293079364184543357003876657387665738815509537956912359787288211420152332942774648154998613431606328718838745361175522675384038803193927831136260733201223320122145307042244796748592314530704224479538813446240551135996062405639278311434934724929001442401911359960144240191697549629140171094471860417761442401914731297728821117537315241327388031914349347144240194335700751257110719883179782561IKN D3454763874621750581614424019287865765723829056163641845152329911324261399733711AP7  1G3N B1K1B A1213987288591580792011814934335700327330775058161DCQ A12139812627432871883880319388134410868583493527237339525703513873911157182061820311310029951419543324471243880319291401729140171723472172375215341604750310024929026580519387676317998549270726828294352829435328718880522331786287814731279
cd00204 Sequence Cluster
cd00204 Sequence Cluster
Sub-family Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                       10        20        30        40        50        60        70        80
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IKN_D      39 NFQN--NLQQTPLHLAVITNQp----eIAEALLGAGCdp------------------eLRDF-RGNTPLHLACEQGCl-- 91
gi 137486  271 NARN--KFGTTPFYCGIIHGIs----lIKLYLESDTE---------------------LEID-NEHIVRHLIIFDAVe-- 320
gi 321379  322 DPLVt-VHGNSSLHYYMRRYMlc--ksVLDILLSTGVdi------------------nGINE-KFHTPLHTYVDKNSk-- 377
gi 321379  143 DVKD--VYGHNLLHLYLKSPYpk--lsIIKLLLDHGVdi-----------------naKTRM-HRHTPLHIYLMNSHmd- 199
gi 321379  288 NQLT--YRGHTPLLVYITMGLf----iESDAITCMIDhg-----------------adPLVTvHGNSSLHYYMRRYMlc- 343
gi 465059  212 NALD--NCGNTPFHLYLSIEMcnnihmTKMLLTFNPNf-------------------eICNN-HGLTPILCYITSDYiq- 268
gi 3097044 222 NKVN--NIGNTPLHNYVSQYDis--prIIFTLLSLGAdl------------------tIQNN-DRLTPIMEYIKCEYi-- 276
gi 3097049 371 ATMDktTDNNYPLHDYFVNNNlvd-vnVVRFIVENNGhmavnhvsn---ngrlcmyglILSR-FNNCGYHCYETILId-- 443
gi 3097050 170 NCVD--EDGLTSLHYYCKHISt----fHESNYYKSSHtkmraekrfiytiidhganinAVTK-IGNTPLHTYLQQYTkhs 242
gi 9802990  75 QAVD--NIGCSALHLCAEHGHy----rMIKLLLQYMKvveqyetp-----efragdkyPQRE-NVDEPLRLAIKNGHy-- 140
                       90       100       110       120       130       140       150       160
               ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
1IKN_D      92 -aSVGVLTQscttphlhsilKATN-YNGH---------TCLHLASIHGy---LGIVELLVslg----------------- 140
gi 137486  321 --SLDYLLSrgv-----idiNYRT-IYNE---------TSIYDAVSYNa---YNTLVYLLnrn----------------- 363
gi 321379  378 -gVAPSIIQymi-----drgVSTA-RLSTtiftesileTFLRRNRQYLnt-tIEVVDYLLtvy----------------- 432
gi 321379  200 kkVVEFLLRng--------aDINY-GNYE---------TPLGTLFSHCs--sFKLIKSITtkl----------------- 242
gi 321379  344 ksVLDILLStgv------diNGIN-EKFH---------TPLHTYVDKNs---KGVAPSIIqymi---------------- 388
gi 465059  269 hdILVMLIHhyet---nvgeMPIDeRRMIv--------FEFIKTYSTRp---LDSITYLMnrf----------------- 317
gi 3097044 277 -eYNTLLMLinwye--skyrKLEK-EEGQ---------HLLHLFIRHNdsngLNILSYLLkkf----------------- 326
gi 3097049 444 --VFDILSKymd------diDMID-NENK---------TLLYYAVDVNn---IQFAKRLLeyg----------------- 485
gi 3097050 243 prVVYALLSrga------dtRIRN-NLDC---------TPIMEYIKNDca-tGHILIMLLnwheqkygklqkeegqhlly 305
gi 9802990 141 -dCARLLLTng--------aNANA-IYFD---------GPEITQVSPLd---TNFLELLLefg----------------- 181
                      170       180       190       200       210       220
               ....*....|....*....|....*....|....*....|....*....|....*....|....*.
1IKN_D     141 ---------------------advNAQEp-CNGR---------TALHLAVdl----qnPDLVSLLL 171
gi 137486  364 ---------------------gdfETIT--TSGC---------TCISEAVan----nnKIIMEVLL 393
gi 321379  433 ----------------------plNEPD--EYGF---------TPLLSAVyavnlnffNHFVKLGA 465
gi 321379  243 ----------------------leYGADi-NFPA---------ASGHSAMmsy--linNPDATVHP 274
gi 321379  389 ---------------------drgVSTA--RLSTtiftesileTFLRRNRqyl--nttIEVVDYLL 429
gi 465059  318 ---------------------kniDIHTr-YEGK---------TLLHIACey----nnTHVIDYLI 348
gi 3097044 327 ---------------------dmkNDEY--YNDI---------TPLHNACia----cnIDIISYLV 356
gi 3097049 486 ---------------------anvNATSl-SIIN---------TAIQKSSyrr---enKTKLVDLL 517
gi 3097050 306 lfikhnqgygshtlnilrylldrfDIQKdeYYNTm--------TPLHTAFqn----cnNNVASYLV 359
gi 9802990 182 ---------------------adpNVFD--RKGL---------TPIMKACrlr--dkgIEAIRILL 213
Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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