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EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit [ Aotus nancymaae (Ma's night monkey) ]

Gene ID: 105711112, updated on 6-Jun-2024

Summary

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Gene symbol
EZH2
Gene description
enhancer of zeste 2 polycomb repressive complex 2 subunit
See related
Ensembl:ENSANAG00000021412
Gene type
protein coding
RefSeq status
MODEL
Organism
Aotus nancymaae
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Aotidae; Aotus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_04 current 86718_ANA_hifiasm-v0.15.2.pri (GCF_030222135.1) Unplaced Scaffold NW_026988413.1 (9417977..9495025)
101 previous assembly Anan_2.0 (GCF_000952055.2) Unplaced Scaffold NW_018506100.1 (4011002..4088961)

NW_026988413.1Genomic Context describing neighboring genes Neighboring gene U6 spliceosomal RNA Neighboring gene protein disulfide isomerase family A member 4 Neighboring gene small ribosomal subunit protein uS19-like Neighboring gene U7 small nuclear RNA Neighboring gene cullin 1 Neighboring gene chromosome unknown C7orf33 homolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables histone H3K27 methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in heterochromatin formation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of ESC/E(Z) complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
histone-lysine N-methyltransferase EZH2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_030222135.1-RS_2024_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

Genomic

  1. NW_026988413.1 Reference 86718_ANA_hifiasm-v0.15.2.pri Primary Assembly

    Range
    9417977..9495025
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012443716.2 → XP_012299139.1  histone-lysine N-methyltransferase EZH2 isoform X1

    See identical proteins and their annotated locations for XP_012299139.1

    UniProtKB/TrEMBL
    A0A2K5CEI6, A0A2K5CEU1
    Related
    ENSANAP00000007105.1
    Conserved Domains (4) summary
    cd19218
    Location:609 → 728
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:158 → 249
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:559 → 590
    preSET_CXC; CXC domain

  2. XM_012443738.2 → XP_012299161.1  histone-lysine N-methyltransferase EZH2 isoform X4

    UniProtKB/TrEMBL
    A0A2K5CEM8, A0A2K5CEU1
    Related
    ENSANAP00000007145.1
    Conserved Domains (4) summary
    cd19218
    Location:570 → 689
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:520 → 551
    preSET_CXC; CXC domain

  3. XM_012443730.2 → XP_012299153.1  histone-lysine N-methyltransferase EZH2 isoform X3

    UniProtKB/TrEMBL
    A0A2K5CEU1
    Conserved Domains (4) summary
    cd19218
    Location:600 → 719
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:550 → 581
    preSET_CXC; CXC domain

  4. XM_064372444.1 → XP_064228514.1  histone-lysine N-methyltransferase EZH2 isoform X5

    UniProtKB/TrEMBL
    A0A2K5CEU1

  5. XM_012443757.2 → XP_012299180.1  histone-lysine N-methyltransferase EZH2 isoform X6

    UniProtKB/TrEMBL
    A0A2K5CET7, A0A2K5CEU1
    Related
    ENSANAP00000007151.1
    Conserved Domains (4) summary
    cd19218
    Location:558 → 677
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:149 → 240
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:508 → 539
    preSET_CXC; CXC domain

  6. XM_012443763.2 → XP_012299186.1  histone-lysine N-methyltransferase EZH2 isoform X7

    UniProtKB/TrEMBL
    A0A2K5CEU1
    Conserved Domains (4) summary
    cd19218
    Location:528 → 647
    SET_EZH2; SET domain found in enhancer of zeste homolog 2 (EZH2) and similar proteins
    pfam11616
    Location:39 → 68
    EZH2_WD-Binding; WD repeat binding protein EZH2
    pfam18118
    Location:119 → 210
    PRC2_HTH_1; Polycomb repressive complex 2 tri-helical domain
    pfam18264
    Location:478 → 509
    preSET_CXC; CXC domain

  7. XM_064372433.1 → XP_064228503.1  histone-lysine N-methyltransferase EZH2 isoform X2

    UniProtKB/TrEMBL
    A0A2K5CEU1
Nucleotide Protein
Heading Accession and Version

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