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APP amyloid beta precursor protein [ Camelus bactrianus (Bactrian camel) ]

Gene ID: 105070278, updated on 13-Mar-2024

Summary

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Gene symbol
APP
Gene description
amyloid beta precursor protein
Gene type
protein coding
RefSeq status
MODEL
Organism
Camelus bactrianus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Tylopoda; Camelidae; Camelus
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
17
Annotation release Status Assembly Chr Location
102 current Ca_bactrianus_MBC_1.0 (GCF_000767855.1) Unplaced Scaffold NW_011514130.1 (9158944..9362458)

NW_011514130.1Genomic Context describing neighboring genes Neighboring gene cysteine and tyrosine rich 1 Neighboring gene uncharacterized LOC105070277 Neighboring gene U6 spliceosomal RNA Neighboring gene GA binding protein transcription factor subunit alpha Neighboring gene ATP synthase peripheral stalk subunit F6 Neighboring gene uncharacterized LOC123617334 Neighboring gene junctional adhesion molecule 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_011514130 Unplaced Scaffold Reference Ca_bactrianus_MBC_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor activator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transition metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in axonogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in central nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell surface IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in early endosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
amyloid-beta precursor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Camelus bactrianus Annotation Release 102 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Ca_bactrianus_MBC_1.0 Primary Assembly

Genomic

  1. NW_011514130.1 Reference Ca_bactrianus_MBC_1.0 Primary Assembly

    Range
    9158944..9362458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_010956629.2 → XP_010954931.1  amyloid-beta precursor protein isoform X3

    UniProtKB/TrEMBL
    A0A9W3ESA0
    Conserved Domains (7) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam00014
    Location:259 → 307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:621 → 659
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:662 → 712
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:312 → 494
    APP_E2; E2 domain of amyloid precursor protein

  2. XM_010956630.2 → XP_010954932.1  amyloid-beta precursor protein isoform X4

    See identical proteins and their annotated locations for XP_010954932.1

    UniProtKB/TrEMBL
    A0A9W3GU18
    Conserved Domains (7) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam00014
    Location:259 → 307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:603 → 641
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:644 → 694
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:312 → 494
    APP_E2; E2 domain of amyloid precursor protein

  3. XM_010956631.2 → XP_010954933.1  amyloid-beta precursor protein isoform X5

    See identical proteins and their annotated locations for XP_010954933.1

    UniProtKB/TrEMBL
    A0A9W3ES74
    Conserved Domains (6) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:565 → 603
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:606 → 656
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:256 → 438
    APP_E2; E2 domain of amyloid precursor protein

  4. XM_010956632.2 → XP_010954934.1  amyloid-beta precursor protein isoform X6

    See identical proteins and their annotated locations for XP_010954934.1

    UniProtKB/TrEMBL
    A0A9W3ES23
    Conserved Domains (6) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:547 → 585
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:588 → 638
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:256 → 438
    APP_E2; E2 domain of amyloid precursor protein

  5. XM_010956627.2 → XP_010954929.1  amyloid-beta precursor protein isoform X1

    UniProtKB/TrEMBL
    A0A9W3ES95
    Conserved Domains (7) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam00014
    Location:259 → 307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:640 → 678
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:681 → 731
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:331 → 513
    APP_E2; E2 domain of amyloid precursor protein

  6. XM_010956628.2 → XP_010954930.1  amyloid-beta precursor protein isoform X2

    See identical proteins and their annotated locations for XP_010954930.1

    UniProtKB/TrEMBL
    A0A9W3ES73
    Conserved Domains (7) summary
    smart00006
    Location:1 → 153
    A4_EXTRA; amyloid A4
    pfam00014
    Location:259 → 307
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam02177
    Location:1 → 96
    APP_N; Amyloid A4 N-terminal heparin-binding
    pfam03494
    Location:622 → 660
    Beta-APP; Beta-amyloid peptide (beta-APP)
    pfam10515
    Location:663 → 713
    APP_amyloid; beta-amyloid precursor protein C-terminus
    pfam12924
    Location:98 → 153
    APP_Cu_bd; Copper-binding of amyloid precursor, CuBD
    pfam12925
    Location:331 → 513
    APP_E2; E2 domain of amyloid precursor protein
Nucleotide Protein
Heading Accession and Version

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