Conserved Protein Domain Family
A4_EXTRA

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smart00006: A4_EXTRA 
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amyloid A4
amyloid A4 precursor of Alzheimers disease
Statistics
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PSSM-Id: 128326
View PSSM: smart00006
Aligned: 6 rows
Threshold Bit Score: 302.115
Threshold Setting Gi: 194911940
Created: 12-Jul-2011
Updated: 16-Jan-2013
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

smart00006 is classified as a model that may span more than one domain.
smart00006 is not assigned to any domain superfamily.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KTM_A         8 GNAGLLAEPQIAMFCGRLNMHMNVQn---GKWDSDPSGTKT---CIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNW 81
gi 189473445 270 GNAGLLAEPQIAMFCGRLNMHMNVQn---GKWDSDPSGTKT---CIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNW 343
gi 149027854  42 GTGFAVAEPQIAMFCGKLNMHVNIQt---GKWEPDPTGTKS---CLGTKEEVLQYCQEIYPELQITNVMEANQPVNIDSW 115
gi 1709301    46 GAPEAPGSAQVAGLCGRLTLHRDLRt---GRWEPDPQRSRR---CLRDPQRVLEYCRQMYPELQIARVEQATQAIPMERW 119
gi 194911940  26 QAASPRWEPQIAVLCEAGQIYQPQYlseeGRWVTDLSKKTTgptCLRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGW 105
gi 1293850    28 SKRHEKFIPMVAFSCGYRNQYMTEE----GSWKTDDERYAT---CFSGKLDILKYCRKAYPSMNITNIVEYSHEVSISDW 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
3KTM_A        82 CKRGRK---QCKTHpHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEK------STNLHDY 152
gi 189473445 344 CKRGRK---QCKTHpHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEK------STNLHDY 414
gi 149027854 116 CRRDKK---QCRS--HIVIPFKCLVGEFVSDVLLVPENCQFFHQERMEVCEKHQRWHTVVKEACLTE------GMTLYSY 184
gi 1709301   120 CGGSRSg--SCAHPhHQVVPFRCLPGEFVSEALLVPEGCRFLHQERMDQCESSTRRHQEAQEACSSQ------GLILHGS 191
gi 194911940 106 CRQGALnaaKCKGShRWIKPFRCLEGPFQSDALLVPEGCLFDHIHNASRCWPFVRWNQTGAAACQER------GMQMRSF 179
gi 1293850   101 CREEGS---PCKWT-HSVRPYHCIDGEFHSEALQVPHDCQFSHVNSRDQCNDYQHWKDEAGKQCKTKkskgnkDMIVRSF 176
                        170       180
                 ....*....|....*....|
3KTM_A       153 GMLLPCGIDKFRGVEFVCCP 172
gi 189473445 415 GMLLPCGIDKFRGVEFVCCP 434
gi 149027854 185 GMLLPCGVDQFHGTEYVCCP 204
gi 1709301   192 GMLLPCGSDRFRGVEYVCCP 211
gi 194911940 180 AMLLPCGISVFSGVEFVCCP 199
gi 1293850   177 AVLEPCALDMFTGVEFVCCP 196
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