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DUOX2 dual oxidase 2 [ Lipotes vexillifer (Yangtze River dolphin) ]

Gene ID: 103071982, updated on 11-Mar-2024

Summary

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Gene symbol
DUOX2
Gene description
dual oxidase 2
Gene type
protein coding
RefSeq status
MODEL
Organism
Lipotes vexillifer
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Whippomorpha; Cetacea; Odontoceti; Lipotidae; Lipotes
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: Un
Exon count:
34
Annotation release Status Assembly Chr Location
100 current Lipotes_vexillifer_v1 (GCF_000442215.1) Unplaced Scaffold NW_006794157.1 (229140..247840, complement)

NW_006794157.1Genomic Context describing neighboring genes Neighboring gene telomere repeat binding bouquet formation protein 2 Neighboring gene sorbitol dehydrogenase Neighboring gene dual oxidase maturation factor 2 Neighboring gene dual oxidase maturation factor 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_006794157 unplaced scaffold reference Lipotes_vexillifer_v1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peroxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables superoxide-generating NAD(P)H oxidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in defense response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in superoxide anion generation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of NADPH oxidase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dual oxidase 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Lipotes vexillifer Annotation Release 100 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Lipotes_vexillifer_v1 Primary Assembly

Genomic

  1. NW_006794157.1 Reference Lipotes_vexillifer_v1 Primary Assembly

    Range
    229140..247840 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007467014.1 → XP_007467076.1  dual oxidase 2

    UniProtKB/TrEMBL
    A0A340Y0A0
    Conserved Domains (6) summary
    cd06186
    Location:1272 → 1546
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 595
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:825 → 886
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1086 → 1221
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:36 → 549
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:825 → 885
    EF-hand_7; EF-hand domain pair

  2. XM_007467013.1 → XP_007467075.1  dual oxidase 2

    UniProtKB/TrEMBL
    A0A340Y6E8
    Conserved Domains (6) summary
    cd06186
    Location:1279 → 1553
    NOX_Duox_like_FAD_NADP; NADPH oxidase (NOX) catalyzes the generation of reactive oxygen species (ROS) such as superoxide and hydrogen peroxide. ROS were originally identified as bactericidal agents in phagocytes, but are now also implicated in cell signaling and metabolism. NOX ...
    cd09820
    Location:38 → 595
    dual_peroxidase_like; Dual oxidase and related animal heme peroxidases
    cd00051
    Location:825 → 886
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    pfam01794
    Location:1093 → 1228
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03098
    Location:36 → 549
    An_peroxidase; Animal haem peroxidase
    pfam13499
    Location:825 → 885
    EF-hand_7; EF-hand domain pair
Nucleotide Protein
Heading Accession and Version

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