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cd09820: dual_peroxidase_like 
Dual oxidase and related animal heme peroxidases
Animal heme peroxidases of the dual-oxidase like subfamily play vital roles in the innate mucosal immunity of gut epithelia. They provide reactive oxygen species which help control infection.
Statistics
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PSSM-Id: 188652
View PSSM: cd09820
Aligned: 18 rows
Threshold Bit Score: 826.168
Threshold Setting Gi: 151427546
Created: 4-Sep-2007
Updated: 17-Jan-2013
Structure
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Aligned Rows:
Hierarchy
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Display:
 
putative hemeputative
Feature 1:putative heme binding site [chemical binding site]
Evidence:

cd09820 is part of a hierarchy of related CD models.
Use the graphical representation to navigate this hierarchy.
cd09820 is a member of the superfamily cl14561.
cd05396:An_peroxidase_likecd09816:prostaglandin_endoperoxide_synthasecd09817:linoleate_diol_synthase_likecd09818:PIOX_likecd09819:An_peroxidase_bacterial_1cd09820:dual_peroxidase_likecd09821:An_peroxidase_bacterial_2cd09822:peroxinectin_like_bacterialcd09823:peroxinectin_likecd09824:myeloperoxidase_likecd09825:thyroid_peroxidasecd09826:peroxidasin_like151427542260800193185136267270015113307195266151427548151427546748704053071899652155010497495979315142754411539185647220523118095470296434485301616998301616996151427542260800193185136267270015113307195266151427548151427546748704053071899652155010497495979315142754411539185647220523118095470296434485301616998301616996
cd09820 Sequence Cluster
cd09820 Sequence Cluster
Sub-family Hierarchy
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 cd09820 Branch
 Whole Hierarchy
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CD Hierarchy
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 74870405    10 YDGWYNNLAHPDWGSVDSHLVRKAPPSYSDGVYAMAGaNRPSTRRLSRLFMRGKDGLGSk-fNRTALLAFFGQLVANEIV 88
gi 151427542   32 YDGWYNNRAHPEWGTVDGPLTRRLPSHYADGTYAPSGgERPNPRTISENTMAGLTGQGSs-tKRTALLVFFGQQVVEEIL 110
gi 185136267  116 YDGWYNNLAHPDWGGAELPLTRRLPVSYADGVYAMAGkDRPNPMSISKATMQGETGQRSh-lRRTALMTFFGQQVVEEIL 194
gi 151427548   11 FNGWYNNLANPSSGATETALTRRLKSHYEDGVYAPSGsGRPNPRTLSVEIASGPSGLHSy-dNKTTLFVYFGQHIIKEIV 89
gi 151427544    3 MDGWYNNLDHPQWGSPGERMIRRSTNGYSNGINKPMEdGLPNPHTLSRLLMRGESGIPSvtgKSVFLAFFAGQHVGDDMI 82
gi 215501049   25 YDGWYNNLAHQDWGAVESQLVRKAPSSYADGVYMIAE-GRPSPRSLSQDLFKGEDGLPSt-rNLTVLFVFFGQVISSEVL 102
gi 260800193   44 YDGWYNNRAHPEWGIADSPLTRRLPSHYQDGTYEPSGwDRPNPRTLSELTMKGVTGMGSf-rNRSALLTFFGQQVVEEVL 122
gi 270015113   59 YDGWYNNIAHPDLGAIDRPLLRRWPTAYEDGSYLPAGsNRPNPLELSEKLLKGETGTKSr-aGKNALIVFFGQQVVEEIL 137
gi 74959793    31 YDGWYNNLANSEWGSAGSRLHRDARSYYSDGVYSVNN-SLPSARELSDILFKGESGIPNt-rGCTTLLAFFSQVVAYEIM 108
gi 307195266   63 YDGWNNNVGKPEFGAVDTPLLRKLPAAYEDGVYKPSGsKRPKPLILSDKLLKGEIGSKSr-tGRNALLVFFGQQVVEEIL 141
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 74870405    89 MASESGCPIEMHRIEIEKCDEMydrecrGDKYIPFHRAAYDr-dTGQSPNAPREQINQMTAWIDGSFIYSTSEAWLNAMR 167
gi 151427542  111 DAQRPGCPPEYFNIKIPKGDPLydktgqGNIELPFLRSRYDmsiTGYSPNNPRQQLNEITPFIDGGLTYGINKAWADALR 190
gi 185136267  195 DAQRGGCPREYENIKIPDGHEYlke-keGISIMPFVRSRYSf-nTGYSPNVPREQLNEITPWFDGGLVYGTTKAWADALR 272
gi 151427548   90 ENSRQGCPPEYFWIPVPEGDEIfdprgdGNIRLPYHRSPYIasnTGYTPNHPRDQLNEVTSLLDGDSIYGSTKAWSGELR 169
gi 151427544   83 DSRRNACPSEYINIEIEENKES------NNHILPMYRSKFIt-gSGSSVNSPRMLVNEATSWLDGSVIYGNSHSWSEHLR 155
gi 215501049  103 MASEPGCPIEFHRIPISRCDEMydskctGQRYMPFHRAHYDv-kTGQSPNNPREQTNLATSWIDASYVYSTSETWANTMR 181
gi 260800193  123 DAQRPGCPREYFNIQIPKGDPEydpdsrGGREIPLLRSRYDmriTGFSPNFPRQQLNEITAFLDGGLMYGVTKAWADALR 202
gi 270015113  138 DAQRPACPPEYFNIEVPQNHTYle--kpGHSQMPFLRTRYDq-rTGYSPNNPRQQLNEITPYLDGGLFYGTTKQWADQLR 214
gi 74959793   109 QSNGVSCPLETLKIQVPLCDNVfdkeceGKTEIPFTRAKYDk-aTGNGLNSPREQINERTSWIDGSFIYGTTQPWVSSLR 187
gi 307195266  142 DAQRPACPPEYINIDIPEGHQYri--kpGHTEMPILRTRYDq-rTGHSPNNPRQQLNEITPYLDGGLIYGTSKAWSDVLR 218
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                 ##      
gi 74870405   168 Sf------hNGTLLTEkdgklp--------vrntmRVPLFNnpvpsvm-------kmlspeRLFLLGDPRTNQNPAILSF 226
gi 151427542  191 Fqskp-tdcRGELASYknegkf-------pienslGLPLANpppprd--------hntyciGLYWLGNPRGNENPFLLTF 254
gi 185136267  273 Sf------kDGRLADNgeiggepq----fpeqntlGLPMANppnpiaeg----aarlqrseRFFKLGNPRGNENPFLLTF 338
gi 151427548  170 Lrk-----qDCELRSAdddgkl-------pmrntiGLPLQNpvvpvyh-------emrnakRLFATGSRTGNENPFLLTI 230
gi 151427544  156 Sf------eRGRLKEEdghpgy-------psfnrnEIPLYNptidlkrp-----pktrnpeELLSFGNPRGNENPFLMTI 217
gi 215501049  182 Sf------eNGTFRTAdtdsrl-------ppknkeRVPLFNspparyl-------gimnpeRMFILGDPRTNQNPGLLAF 241
gi 260800193  203 Llss---drRGRLASCtdqgvpgcvndmypayntiGLPMANppppreh-------ylkssrRFFKLGNPRGNENAFLLTF 272
gi 270015113  215 Ty------eNGTIDPDgclasshdg--lfpayntqRLPLANppppiyhsmfikshetakvsRFFKLGNPRGNENSFLLTF 286
gi 74959793   188 Sf------kQGRLAEGvpgyp---------plnnpHIPLNNpappqvh-------rlmspdRLFMLGDSRVNENPGLLSF 245
gi 307195266  219 TyangtvhpGGELASSlsglyp--------ernsvRLPMANppppahhslyvsrhyteevtRYFKLGNPRGNENPFLLTF 290
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 74870405   227 AILFLRWHNTLAQRIKRVHpDWSDEDIYQRARHTVIASLQNVIVYEYLPAFLGTSL-----PPYEGYKQDIHPGIGHIFQ 301
gi 151427542  255 GVLWFRHHNWLARYIRDKHsTWSDEKVYNEARILNIAIHQKIIFYDWLPLFLGECL-----PTYTGYKSAIHPGITHVFQ 329
gi 185136267  339 GVLWFRWHNYWADKFKAET-DWEDERIFNEARKWVIATYQSVVFYEWLPGYLNLNEnetaeVEYSGYKGYIHPGITHEFQ 417
gi 151427548  231 GVTWFRHHNWLARQLRDNNpDWSDEHVFMESRTRNIATYQKVFFYEWLPILLGSCP-----SKWTGYHASVPVGVSNVFQ 305
gi 151427544  218 EIIWFRWHNHLAEKIAVQNpDWSDQQIFDKARKWTIATYQNIAFYEWLPEIIGTSP-----PPYREYNKFMLPSVSVEFS 292
gi 215501049  242 GILFFRYHNVHALRIKNTHpDWTDEDIFLHARRYVIAAMQNVIVYEYVPTLLGENV-----TEYTGYKPDVHPGISHEFQ 316
gi 260800193  273 GVFWFRWHNYLADQIAAKNlDWSDERVFNEARKWVIATHQKIVLYDWLPDFLGENRr---pADYKGYSSAVHPGVTHVFQ 349
gi 270015113  287 GIMWFRWHNYLAKRIRILRpEWPSEKVFNEARKWVIATQQKIVVYDWLPEWIFEDL-----PDYGGYDPGVDPQIDQFFQ 361
gi 74959793   246 GLILFRWHNYNANQIHREHpDWTDEQIFQAARRLVIASMQKIIAYDFVPGLLGEDVr---lSNYTKYMPHVPPGISHAFG 322
gi 307195266  291 GIVWFRWHNFLAKHIKRLNpDWSSEKIYNEARKWVIATQQHIVVNEWLPSWLGTEL-----SNYIGYNPNIDPQIDQFFQ 365
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1         #  ### #  #                                                #                    
gi 74870405   302 AAAFRFGHTMIPPGIYRRDGQCNfke--------------------tpmGYPAVRLCSTWWDSSGFFAD----------T 351
gi 151427542  330 SAAMRIGHTLVPPGVYRRTNYNTttkqctflnttlktagdrhafqalhvNKPGLRTCNTYWNSLEAVVE----------S 399
gi 185136267  418 SAAMRFGHTLVPPGVMRRNEQCVfrtstmkssgf----tedqdefsesqGNHGVRTCNSFWNPQHSVRE----------H 483
gi 151427548  306 SAAMNYLDTMVPPGGFIPKTFDRfvlea----------------sinsdEMDKWRTCNTYWNSDELFEN----------A 359
gi 151427544  293 IAAMRLGHSLVPSGVVLRQPDCSpidplpe-------------dylasaGEPALRLCNTYWQLQDALLD----------L 349
gi 215501049  317 AAAFRFPHTSIPPGIYRRDRSCNfld--------------------tknGFKALRLCSTWWLSEEVLPA----------S 366
gi 260800193  350 SAAMRWGHTIVPPGVYRRSRVKPdgtcdwrntt------yytsphtsgqYFHGVRTCNSYWNSVEPHEEgfkaedvapfD 423
gi 270015113  362 SAAFRFGHTLVVPGVYLRDYARNgckhk-----------------fdtwGQNTVRTCNSFWRPYEPIVKpvdeg-ksevI 423
gi 74959793   323 AAAFRFPHSIVPPAMLLRKRGNKcefr------------------tevgGYPALRLCQNWWNAQDIVKE----------Y 374
gi 307195266  366 SAAFRFGHTLVPPGVYLRNYGRNnc----------------------slERFPIRTCNNYWMSQNSLFAnfte---misV 420
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                #  #   #                                 
gi 74870405   352 SVEEVLMGLASQISEREDPVLCSDVRDKLfgpmefTRRDLGALNIMRGRDNGLPDYNTARESYGLKRHKTwtdinp---- 427
gi 151427542  400 DIDQLLMGMSSQVAEKEDNIITPDLRGSVfgpldfSRRDLMALNIQRGRDHGLPDYNTARASFGLKKRTTfeeinp---- 475
gi 185136267  484 DIEEFLLGMASQVTEREDNIITEDLQRRVfgplefSRRDLMALNIQRGRDHGLPDYNTARVSLGMDRRETfesinnasah 563
gi 151427548  360 TPFNIVYGMMGQMAESEDHIISEDLRNSF------HGSMEFSRTDKRGRDHGLPDYNTAREDLGLKKKETirdinp---- 429
gi 151427544  350 GIEGIVLGMTSQNAEEEDAVVVDDLAGFLygplkrTRMDLEAMTIQRGRDAGLQRYNEVRKTYDLPPITDfsql------ 423
gi 215501049  367 GVDEFLLGMASQIAEKEDQILCSDVRDKLfgpmefTRRDLAALDIMRGRDNGLPDYNTVRRHFGLPAITTwtqine---- 442
gi 260800193  424 GMAEFLLGMSSQVTEREDNIITEDLRGRVfgplefSRRDLMAINIQRGRDHGLPDYNTARVEYGLPPRKTfydvnpwl-- 501
gi 270015113  424 DIDRLLMGMAVQLCEEEDHKIVEDLRGNVfgplefPRRDLMALNIQRGRDHGIPDYNTVRRAYGLKKQTFgdf------- 496
gi 74959793   375 SVDEIILGMASQIAERDDNIVVEDLRDYIfgpmhfSRLDVVASSIMRGRDNGVPPYNELRRTFGLAPKTWetmne----- 449
gi 307195266  421 NVDKLLMGMAIQLCEEEDHKIVEDLRGSLfgplefSRRDLMALNIQRGRDHGVPDFNSARRAYGLHEVKNishf------ 494
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 74870405   428 ---plfetQPELLDMLKEAYDn---KLDDVDVYVGGMLESYGQ-PGEFFTAVIKEQFQRLRDADRFWFENERNG-IFTPE 499
gi 151427542  476 ---dlfaaTPGLLGNLTATHDd---DISKLDVWTGGLLETLSTgPGELFRHIIRDQFIRIRDGDRFWYENSQNG-LLTAE 548
gi 185136267  564 adgvetfiDSEVLDNLARVYEn---DIDKVDIWAGGLLETTSNgPGELFRFIILDQFVRSRDADRFWFENNVSG-QFTND 639
gi 151427548  430 ---dlfkkDEKLLERLHSLHGg---SPSNMDIYVGGMLESKDGrPGELFRSIILEQMVRLRDGDRFWFENLNNG-LFTVD 502
gi 151427544  424 ----npslPNEVIARLRNAYNn---DTNKLELYVAGMMEDRSNaSNVLFYKIILEQFQRTRDGDRLWFENAQNG-LFNAS 495
gi 215501049  443 ---klarsNPEIFEKLRKLYHd---NLDNVDLFVGGMLESDEGrPGPLFRKIIREQFERLRDADRFWFENVHNGpRARAD 516
gi 260800193  502 fngtyvehGPELLANITAFATannwTTDKCDIWVCGLLETTEAgPGELFGAVIKDQFERIRDGDRFWYENDKNG-LFTKG 580
gi 270015113  497 -----ghlPMKIKEEFEKLYS----SDEDVDLWIGGILETKDHkPGELFRTIIKDQFRRIRDGDRFWFENKENG-LFSND 566
gi 74959793   450 ---dfykkHTAKVEKLKELYGg---NILYLDAYVGGMLEGGENgPGELFKEIIKDQFTRIRDGDRFWFENKLNG-LFTDE 522
gi 307195266  495 -----vhvSPEIKNEFLKLYN----SFDDVDIWVGGILETGDT-PGELFREIIRDQFQRIRDGDRFWYKNLNNE-LFTGK 563
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
Feature 1                                                                                         
gi 74870405   500 EIAELRKI-TLWDIIVNSTDVKEEEIQkdvf-----mwrtGDPCPQPMQLN----------------ATELEPCT---YL 554
gi 151427542  549 DLAFVQAT-TIRDVILRTNPTMNATYDiqnnpfqaaendsSLYCPQPRQLS----------------ELHMEECT---EP 608
gi 185136267  640 QIDFIKKV-KLWDIIVACTNINGSSLQkdpf-----hytpDDPCYDQHPFEgenr---------tisENDMENCT---KL 701
gi 151427548  503 QVNGIFNV-TFLDVLLRTYPELNLAGNtafnpf--iwksnKHICRQPYQMT----------------GDNMTSCT---TM 560
gi 151427544  496 ELQEIRQT-TMRDIIAATTTFNRSLFQpnvf------ntaGSRCASITVRK----------------DMFSKSCT---PN 549
gi 215501049  517 RYLSFQPAmEAVDIPLGVSSPQQINSSv------------LEPCMILDGWDyfr----------gneVAYIYSCL---VL 571
gi 260800193  581 EIEQINNI-TLFDIIKSISNITDADMQsnpf------iatDSPCFQPKQLS----------------QFDMEPCTpdtVD 637
gi 270015113  567 EVERIKQI-TLYDVIMAVTRMDPDDLPkn---------vfNVPTDTDVQLIsk-------------cNLTKSSCT---SK 620
gi 74959793   523 EVQMIHSI-TLRDIIKATTDIDETMLQkdvf-----ffkeGDPCPQPFQVN----------------TTGLEPCV---PF 577
gi 307195266  564 EVIRIDEL-SFYDLLMCITEMDWNDIPrnpfrvptkeeemHPNCKKNNVIKkgacttgpcfhaeqinENNIEKCT---EP 639

                  ....*....
Feature 1                  
gi 74870405   555 EGYDYFSGS 563
gi 151427542  609 ESFDYFTGS 617
gi 185136267  702 QTFDYFEGS 710
gi 151427548  561 QRQDDFNHN 569
gi 151427544  550 TGIDFFYGY 558
gi 215501049  572 AFIPISEHP 580
gi 260800193  638 KTVDFKRET 646
gi 270015113  621 DSTNFNCHH 629
gi 74959793   578 MQSTYWTDN 586
gi 307195266  640 GTYDFFSNS 648

Citing CDD
Marchler-Bauer A et al. (2013), "CDD: conserved domains and protein three-dimensional structure.", Nucleic Acids Res. 41(D1):D384-52.
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