NOD2 nucleotide binding oligomerization domain containing 2 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: NOD2provided by VGNC
Official Full Name: nucleotide binding oligomerization domain containing 2provided by VGNC
Primary source: VGNC:VGNC:98520
See related: Ensembl:ENSSSCG00000038073
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Annotation information: Annotation category: partial on reference assembly
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	6	NC_010448.4 (34132127..34167446, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	Unplaced Scaffold	NW_003541192.1 (51206..54827)

Chromosome 6 - NC_010448.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population.
Title: NOD2 Genotypes Affect the Symptoms and Mortality in the Porcine Circovirus 2-Spreading Pig Population.
Luciferase reporter gene assays showed significant differences in promoter activity between allele variants of NOD1 -920G>A (NC_010460.4:g.42431413G>A) and NOD2 -1670G>A (NC_010448.4:g.34169122T>C) SNPs. The results suggest that promoter polymorphisms could modify the expression levels of porcine NOD1 and NOD2 genes.
Title: Identification and functional characterization of polymorphisms in promoter sequences of porcine NOD1 and NOD2 genes.
These findings suggest that the 2197C allele of NOD2 might confer an immune response advantage in modern pig breeds and may be a useful marker for breeding aimed at disease resistance in pigs.
Title: Influence of polymorphisms in porcine NOD2 on ligand recognition.
NOD2 abounds in nonsynonymous SNPs both throughout the coding sequence and in sequences encoding domains important for ligand recognition. There are 7 SNPs in its leucine-rich repeat section.
Title: Differences in distribution of single nucleotide polymorphisms among intracellular pattern recognition receptors in pigs.
These results implicate NOD2 as an important immunoregulator in the swine intestinal immunity.
Title: Molecular cloning and functional characterization of porcine nucleotide-binding oligomerization domain-2 (NOD2).

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: nucleotide-binding oligomerization domain-containing protein 2

Names: nucleotide-binding oligomerization domain 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001105295.1 → NP_001098765.1 nucleotide-binding oligomerization domain-containing protein 2

See identical proteins and their annotated locations for NP_001098765.1

Status: PROVISIONAL

Source sequence(s)

AB195466

UniProtKB/TrEMBL

A0A8D0JIB1, A7VJM2

Related

ENSSSCP00000057048.2, ENSSSCT00000041200.3

Conserved Domains (6) summary

smart00382
Location:267 → 366

AAA; ATPases associated with a variety of cellular activities

COG4886
Location:768 → 1011

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00116
Location:793 → 983

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

sd00033
Location:762 → 789

LRR_RI; leucine-rich repeat [structural motif]

pfam05729
Location:266 → 436

NACHT; NACHT domain

cl14633
Location:7 → 92

DD; Death Domain Superfamily of protein-protein interaction domains