IRX9 Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: IRX9
Gene description: Nucleotide-diphospho-sugar transferases superfamily protein
Primary source: Araport:AT2G37090
Locus tag: AT2G37090
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: IRREGULAR XYLEM 9; T2N18.15; T2N18_15
Summary: The IRX9 gene encodes a putative family 43 glycosyl transferase. It was coordinately expressed with the cellulose synthase subunits during secondary cell wall formation. Cell wall analysis revealed a decrease in the abundance of xylan in the irx9 mutant, indicating that IRX9 is required for xylan synthesis. Mutants have irregular xylem phenotype suggesting a role in secondary cell wall biosynthesis.
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Genomic context

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Location:: chromosome: 2

Exon count:: 3

Sequence:: Chromosome: 2; NC_003071.7 (15587394..15589369, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Organization of Xylan Production in the Golgi During Secondary Cell Wall Biosynthesis.
Title: Organization of Xylan Production in the Golgi During Secondary Cell Wall Biosynthesis.
KNAT7 activates the promoters of the xylan biosynthetic genes, IRREGULAR XYLEM 9 (IRX9), IRX10, IRREGULAR XYLEM 14-LIKE (IRX14L), and FRAGILE FIBER 8 (FRA8).
Title: KNAT7 positively regulates xylan biosynthesis by directly activating IRX9 expression in Arabidopsis.
The putative glycosyltransferases IRX9, IRX14, and IRX10 (or the paralogs IRX9L, IRX14L, and IRX10L) are required for xylan backbone synthesis in Arabidopsis.
Title: Site-directed mutagenesis of IRX9, IRX9L and IRX14 proteins involved in xylan biosynthesis: glycosyltransferase activity is not required for IRX9 function in Arabidopsis.
The enzymatic activities of two Arabidopsis thaliana GT43 members, IRX9 (Irregular Xylem9) and IRX14, were investigated.
Title: Arabidopsis family GT43 members are xylan xylosyltransferases required for the elongation of the xylan backbone.
Double mutations of IRX9 and IRX14 were shown to cause a loss of secondary wall thickening in fibers and a much more severe reduction in glucuronoxylan synthesis.
Title: The Arabidopsis family GT43 glycosyltransferases form two functionally nonredundant groups essential for the elongation of glucuronoxylan backbone.
Results suggest that IRREGULAR XYLEM9 (IRX9) is required for normal glucuronoxylan (GX)elongation and indicate roles for IRX8 and FRA8 in the synthesis of the glycosyl sequence at the GX reducing end.
Title: Arabidopsis irregular xylem8 and irregular xylem9: implications for the complexity of glucuronoxylan biosynthesis.

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Pathways from PubChem

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General gene information

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Homology

Orthologs from OrthoDB

NM_129265.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 1,4-beta-D-xylan synthase activity	IEA Inferred from Electronic Annotation more info
enables galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables xylosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucuronoxylan biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within glucuronoxylan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plant-type secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within xylan biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Nucleotide-diphospho-sugar transferases superfamily protein

NP_181246.1

IRREGULAR XYLEM 9 (IRX9); CONTAINS InterPro DOMAIN/s: Glycosyl transferase, family 43 (InterPro:IPR005027); BEST Arabidopsis thaliana protein match is: Nucleotide-diphospho-sugar transferases superfamily protein (TAIR:AT1G27600.2); Has 591 Blast hits to 584 proteins in 85 species: Archae - 0; Bacteria - 0; Metazoa - 323; Fungi - 0; Plants - 254; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

15587394..15589369 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_129265.3 → NP_181246.1 Nucleotide-diphospho-sugar transferases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_181246.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9ZQC6

UniProtKB/TrEMBL

A0A178VRM9, A0A654F4V5, W8QNT8

Conserved Domains (1) summary

PLN02458
Location:1 → 350

PLN02458; transferase, transferring glycosyl groups