Slc28a1 solute carrier family 28 member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc28a1provided by RGD
Official Full Name: solute carrier family 28 member 1provided by RGD
Primary source: RGD:621223
See related: Ensembl:ENSRNOG00000018940 AllianceGenome:RGD:621223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cnt1
Summary: Enables pyrimidine- and adenine-specific:sodium symporter activity. Involved in pyrimidine nucleobase transport. Located in apical plasma membrane. Orthologous to human SLC28A1 (solute carrier family 28 member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 56.4) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q31

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (144490453..144532025)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (135079375..135122791)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (142948942..142992410)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Diabetes increased CNT1 and CNT3 expression in the glomerulus and insulin treatment decreased it
Title: Expression of concentrative nucleoside transporters SLC28 (CNT1, CNT2, and CNT3) along the rat nephron: effect of diabetes.
Cell-cycle-dependent regulation of CNT1 protein levels in a rat hepatoma cell line.
Title: Cell-cycle-dependent regulation of CNT1, a concentrative nucleoside transporter involved in the uptake of cell-cycle-dependent nucleoside-derived anticancer drugs.

Submit: New GeneRIF Correction

General gene information

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Markers

RH127467 (e-PCR)
- UniSTS:210777

44.MMHAP69FRG11.seq (e-PCR)
- UniSTS:124544

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables azole transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables azole transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine nucleobase transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine- and adenosine-specific:sodium symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrimidine- and adenosine-specific:sodium symporter activity	IEA Inferred from Electronic Annotation more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISO Inferred from Sequence Orthology more info
enables pyrimidine- and adenosine-specific:sodium symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables uridine transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables uridine transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in azole transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in azole transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytidine transport	IEA Inferred from Electronic Annotation more info
involved_in cytidine transport	ISO Inferred from Sequence Orthology more info
involved_in cytidine transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in nucleoside import across plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in nucleoside import across plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in nucleoside transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in nucleoside transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in nucleoside transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in purine nucleobase transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine nucleobase transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in pyrimidine nucleobase transport	IDA Inferred from Direct Assay more info	PubMed
involved_in pyrimidine nucleobase transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in pyrimidine-containing compound transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in uridine transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in uridine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in uridine transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	IEA Inferred from Electronic Annotation more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: sodium/nucleoside cotransporter 1

Names: CNT 1; Na(+)/nucleoside cotransporter 1; concentrative nucleoside transporter 1; sodium-coupled nucleoside transporter 1; solute carrier family 28 (concentrative nucleoside transporter), member 1; solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053863.1 → NP_446315.1 sodium/nucleoside cotransporter 1

See identical proteins and their annotated locations for NP_446315.1

Status: PROVISIONAL

Source sequence(s)

U10279

UniProtKB/Swiss-Prot

Q62674

UniProtKB/TrEMBL

A0A0G2JX14

Related

ENSRNOP00000025621.2, ENSRNOT00000025621.4

Conserved Domains (1) summary

TIGR00804
Location:179 → 590

nupC; nucleoside transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

144490453..144532025

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111025.2 → XP_038966953.1 sodium/nucleoside cotransporter 1 isoform X1

UniProtKB/TrEMBL

A0A0G2JX14, F1LNH7

Conserved Domains (1) summary

TIGR00804
Location:179 → 590

nupC; nucleoside transporter
XM_063264885.1 → XP_063120955.1 sodium/nucleoside cotransporter 1 isoform X1

UniProtKB/TrEMBL

F1LNH7
XM_039111054.2 → XP_038966982.1 sodium/nucleoside cotransporter 1 isoform X2

Conserved Domains (1) summary

TIGR00804
Location:3 → 327

nupC; nucleoside transporter
XM_039111077.1 → XP_038967005.1 sodium/nucleoside cotransporter 1 isoform X3

Conserved Domains (1) summary

TIGR00804
Location:1 → 314

nupC; nucleoside transporter