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SLC28A1 solute carrier family 28 member 1 [ Homo sapiens (human) ]

Gene ID: 9154, updated on 22-Aug-2020

Summary

Official Symbol
SLC28A1provided by HGNC
Official Full Name
solute carrier family 28 member 1provided by HGNC
Primary source
HGNC:HGNC:11001
See related
Ensembl:ENSG00000156222 MIM:606207
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNT1; HCNT1; URCTU
Expression
Biased expression in kidney (RPKM 9.5), small intestine (RPKM 9.4) and 2 other tissues See more
Orthologs

Genomic context

See SLC28A1 in Genome Data Viewer
Location:
15q25.3
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (84884350..84975649)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85427794..85489027)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 592 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene alpha kinase 3 Neighboring gene RNA, U6 small nuclear 339, pseudogene Neighboring gene RNA, U6 small nuclear 796, pseudogene Neighboring gene high mobility group box 1 pseudogene 43 Neighboring gene phosphodiesterase 8A Neighboring gene nucleolar protein interacting with the FHA domain of MKI67 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
GeneReviews: Not available
URIDINE-CYTIDINEURIA
MedGen: C4760647 OMIM: 618477 GeneReviews: Not available
not available

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
azole transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
cytidine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
cytidine transmembrane transporter activity TAS
Traceable Author Statement
more info
PubMed 
nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside:sodium symporter activity TAS
Traceable Author Statement
more info
 
purine nucleobase transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
pyrimidine- and adenine-specific:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uridine transmembrane transporter activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
azole transport IDA
Inferred from Direct Assay
more info
PubMed 
cytidine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytidine transport IDA
Inferred from Direct Assay
more info
PubMed 
cytidine transport TAS
Traceable Author Statement
more info
PubMed 
nucleobase-containing compound metabolic process TAS
Traceable Author Statement
more info
PubMed 
nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
nucleoside transport TAS
Traceable Author Statement
more info
PubMed 
purine nucleobase transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
pyrimidine nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
pyrimidine-containing compound transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
uridine transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
uridine transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/nucleoside cotransporter 1
Names
Na(+)/nucleoside cotransporter 1
concentrative nucleoside transporter 1
sodium-coupled nucleoside transporter 1
solute carrier family 28 (concentrative nucleoside transporter), member 1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287761.2NP_001274690.1  sodium/nucleoside cotransporter 1 isoform 3

    See identical proteins and their annotated locations for NP_001274690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks three in-frame exons in the 3' coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC087468, AK296075
    Consensus CDS
    CCDS73777.1
    UniProtKB/TrEMBL
    B7Z3L6
    Related
    ENSP00000443752.1, ENST00000538177.5
    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  2. NM_001287762.2NP_001274691.1  sodium/nucleoside cotransporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001274691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC087468, AK296075, U62968
    Consensus CDS
    CCDS10334.1
    UniProtKB/Swiss-Prot
    O00337
    UniProtKB/TrEMBL
    B7Z3L6
    Related
    ENSP00000286749.3, ENST00000286749.3
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  3. NM_001321721.2NP_001308650.1  sodium/nucleoside cotransporter 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087468, AK296074, AK298369
    UniProtKB/TrEMBL
    B7Z3L5, B7Z533
    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367535
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  4. NM_001321722.2NP_001308651.1  sodium/nucleoside cotransporter 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087468, AK296074, AK298369
    UniProtKB/TrEMBL
    B7Z3L5, B7Z533
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  5. NM_004213.5NP_004204.3  sodium/nucleoside cotransporter 1 isoform 1

    See identical proteins and their annotated locations for NP_004204.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC087468, AK296074, U62968
    Consensus CDS
    CCDS10334.1
    UniProtKB/Swiss-Prot
    O00337
    UniProtKB/TrEMBL
    B7Z3L5
    Related
    ENSP00000378074.1, ENST00000394573.6
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  6. NM_201651.3NP_964014.1  sodium/nucleoside cotransporter 1 isoform 2

    See identical proteins and their annotated locations for NP_964014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK296075, BC029788, BI765705
    Consensus CDS
    CCDS10335.1
    UniProtKB/Swiss-Prot
    O00337
    UniProtKB/TrEMBL
    B7Z3L6
    Related
    ENSP00000341629.2, ENST00000338602.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    84884350..84975649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522208.3XP_011520510.1  sodium/nucleoside cotransporter 1 isoform X2

    Conserved Domains (4) summary
    TIGR00804
    Location:170581
    nupC; nucleoside transporter
    pfam01773
    Location:175244
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:358581
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:256352
    Gate; Nucleoside recognition
  2. XM_011522211.3XP_011520513.1  sodium/nucleoside cotransporter 1 isoform X6

    See identical proteins and their annotated locations for XP_011520513.1

    Conserved Domains (4) summary
    TIGR00804
    Location:101512
    nupC; nucleoside transporter
    pfam01773
    Location:106175
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:289512
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:187283
    Gate; Nucleoside recognition
  3. XM_024450100.1XP_024305868.1  sodium/nucleoside cotransporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00804
    Location:179564
    nupC; nucleoside transporter
  4. XM_024450101.1XP_024305869.1  sodium/nucleoside cotransporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00804
    Location:179564
    nupC; nucleoside transporter
  5. XM_011522204.3XP_011520506.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520506.1

    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  6. XM_011522205.3XP_011520507.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520507.1

    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  7. XM_024450099.1XP_024305867.1  sodium/nucleoside cotransporter 1 isoform X1

    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  8. XM_011522206.3XP_011520508.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520508.1

    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  9. XM_011522203.2XP_011520505.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520505.1

    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  10. XM_011522215.2XP_011520517.1  sodium/nucleoside cotransporter 1 isoform X9

    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  11. XM_011522209.2XP_011520511.1  sodium/nucleoside cotransporter 1 isoform X3

    Conserved Domains (1) summary
    TIGR00804
    Location:179564
    nupC; nucleoside transporter
  12. XM_017022723.1XP_016878212.1  sodium/nucleoside cotransporter 1 isoform X5

  13. XM_011522212.1XP_011520514.1  sodium/nucleoside cotransporter 1 isoform X7

    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367509
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  14. XM_011522210.2XP_011520512.1  sodium/nucleoside cotransporter 1 isoform X4

    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  15. XM_011522217.1XP_011520519.1  sodium/nucleoside cotransporter 1 isoform X10

    See identical proteins and their annotated locations for XP_011520519.1

    UniProtKB/TrEMBL
    B7Z3L6
    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  16. XM_011522214.2XP_011520516.1  sodium/nucleoside cotransporter 1 isoform X8

    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367509
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  17. XM_011522218.2XP_011520520.1  sodium/nucleoside cotransporter 1 isoform X11

    Conserved Domains (2) summary
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  18. XM_024450102.1XP_024305870.1  sodium/nucleoside cotransporter 1 isoform X12

    Conserved Domains (1) summary
    cl26873
    Location:15243
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
  19. XM_011522216.2XP_011520518.1  sodium/nucleoside cotransporter 1 isoform X6

    See identical proteins and their annotated locations for XP_011520518.1

    Conserved Domains (4) summary
    TIGR00804
    Location:101512
    nupC; nucleoside transporter
    pfam01773
    Location:106175
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:289512
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:187283
    Gate; Nucleoside recognition

RNA

  1. XR_931944.2 RNA Sequence

  2. XR_002957690.1 RNA Sequence

  3. XR_931945.2 RNA Sequence

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