U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC28A1 solute carrier family 28 member 1 [ Homo sapiens (human) ]

Gene ID: 9154, updated on 1-Mar-2024

Summary

Official Symbol
SLC28A1provided by HGNC
Official Full Name
solute carrier family 28 member 1provided by HGNC
Primary source
HGNC:HGNC:11001
See related
Ensembl:ENSG00000156222 MIM:606207; AllianceGenome:HGNC:11001
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CNT1; HCNT1; URCTU
Summary
Enables azole transmembrane transporter activity; cytidine transmembrane transporter activity; and uridine transmembrane transporter activity. Involved in azole transmembrane transport; nucleoside transport; and pyrimidine-containing compound transmembrane transport. Located in cytosol; nuclear speck; and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney (RPKM 9.5), small intestine (RPKM 9.4) and 2 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SLC28A1 in Genome Data Viewer
Location:
15q25.3
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (84884662..84975649)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (82637040..82727893)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (85427893..85518880)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85291347-85292186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9992 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41887 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85303845-85304346 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309319-85309820 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85309821-85310320 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9993 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85325731-85326318 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85326319-85326906 Neighboring gene zinc finger protein 592 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41909 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85346873-85347374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85347375-85347874 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85359685-85360215 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362343-85362874 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85362875-85363404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85370192-85370692 Neighboring gene skeletal muscle cis-regulatory module overlapping ALPK3 Neighboring gene uncharacterized LOC124900361 Neighboring gene alpha kinase 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85405349-85405850 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85406419-85406920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85406921-85407420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85426972-85427472 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85427473-85427973 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:85432908-85433476 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9994 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85467385-85467885 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9995 Neighboring gene RNA, U6 small nuclear 339, pseudogene Neighboring gene RNA, U6 small nuclear 796, pseudogene Neighboring gene high mobility group box 1 pseudogene 43 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41947 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85522585-85523086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:85523087-85523586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6775 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:85524736-85525268 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9997 Neighboring gene Sharpr-MPRA regulatory region 10787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6777 Neighboring gene phosphodiesterase 8A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9998 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9999 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10001 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_41972 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42025 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:85668261-85668811 Neighboring gene uncharacterized LOC124903545 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_42032 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr15:85708039-85708575 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6778 Neighboring gene NIFK pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Uridine-cytidineuria
MedGen: C4760647 OMIM: 618477 GeneReviews: Not available
not available

EBI GWAS Catalog

Description
Genome-wide association analysis of age-at-onset in Alzheimer's disease.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in azole transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytidine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cytidine transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cytidine transport TAS
Traceable Author Statement
more info
PubMed 
involved_in nucleoside import across plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleoside transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in nucleoside transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in purine nucleobase transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in pyrimidine nucleobase transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in pyrimidine-containing compound transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
involved_in uridine transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in uridine transport IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in brush border membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
sodium/nucleoside cotransporter 1
Names
Na(+)/nucleoside cotransporter 1
concentrative nucleoside transporter 1
sodium-coupled nucleoside transporter 1
solute carrier family 28 (concentrative nucleoside transporter), member 1
solute carrier family 28 (sodium-coupled nucleoside transporter), member 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001287761.2NP_001274690.1  sodium/nucleoside cotransporter 1 isoform 3

    See identical proteins and their annotated locations for NP_001274690.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the 5' UTR and lacks three in-frame exons in the 3' coding region, compared to variant 1. This variant encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AC087468, AK296075
    Consensus CDS
    CCDS73777.1
    UniProtKB/TrEMBL
    B7Z3L6
    Related
    ENSP00000443752.1, ENST00000538177.5
    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  2. NM_001287762.2NP_001274691.1  sodium/nucleoside cotransporter 1 isoform 1

    See identical proteins and their annotated locations for NP_001274691.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC087468, AK296075, U62968
    Consensus CDS
    CCDS10334.1
    UniProtKB/Swiss-Prot
    A0AV42, A8K7I2, O00335, O00336, O00337, Q5U5S6, Q5U648, Q9UEZ9
    UniProtKB/TrEMBL
    Q96PL7
    Related
    ENSP00000286749.3, ENST00000286749.3
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  3. NM_001321721.2NP_001308650.1  sodium/nucleoside cotransporter 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087468, AK296074, AK298369
    UniProtKB/TrEMBL
    B7Z3L5, B7Z533
    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367535
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  4. NM_001321722.2NP_001308651.1  sodium/nucleoside cotransporter 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087468, AK296074, AK298369
    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  5. NM_004213.5NP_004204.3  sodium/nucleoside cotransporter 1 isoform 1

    See identical proteins and their annotated locations for NP_004204.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1 and 4 encode the same protein.
    Source sequence(s)
    AC087468, AK296074, U62968
    Consensus CDS
    CCDS10334.1
    UniProtKB/Swiss-Prot
    A0AV42, A8K7I2, O00335, O00336, O00337, Q5U5S6, Q5U648, Q9UEZ9
    UniProtKB/TrEMBL
    Q96PL7
    Related
    ENSP00000378074.1, ENST00000394573.6
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  6. NM_201651.3NP_964014.1  sodium/nucleoside cotransporter 1 isoform 2

    See identical proteins and their annotated locations for NP_964014.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK296075, BC029788, BI765705
    Consensus CDS
    CCDS10335.1
    UniProtKB/Swiss-Prot
    O00337
    UniProtKB/TrEMBL
    B7Z3L6
    Related
    ENSP00000341629.2, ENST00000338602.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    84884662..84975649
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522204.4XP_011520506.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520506.1

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  2. XM_011522203.3XP_011520505.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520505.1

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  3. XM_011522215.3XP_011520517.1  sodium/nucleoside cotransporter 1 isoform X8

    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  4. XM_011522209.3XP_011520511.1  sodium/nucleoside cotransporter 1 isoform X3

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (1) summary
    TIGR00804
    Location:179564
    nupC; nucleoside transporter
  5. XM_011522205.4XP_011520507.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520507.1

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  6. XM_011522206.4XP_011520508.1  sodium/nucleoside cotransporter 1 isoform X1

    See identical proteins and their annotated locations for XP_011520508.1

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (1) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
  7. XM_011522208.4XP_011520510.1  sodium/nucleoside cotransporter 1 isoform X2

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:170581
    nupC; nucleoside transporter
    pfam01773
    Location:175244
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:358581
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:256352
    Gate; Nucleoside recognition
  8. XM_017022723.2XP_016878212.1  sodium/nucleoside cotransporter 1 isoform X5

    UniProtKB/TrEMBL
    B7Z3L5
  9. XM_011522212.2XP_011520514.1  sodium/nucleoside cotransporter 1 isoform X6

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367509
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  10. XM_011522210.3XP_011520512.1  sodium/nucleoside cotransporter 1 isoform X4

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:179590
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367590
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  11. XM_011522217.2XP_011520519.1  sodium/nucleoside cotransporter 1 isoform X9

    See identical proteins and their annotated locations for XP_011520519.1

    UniProtKB/TrEMBL
    B7Z3L6
    Conserved Domains (4) summary
    TIGR00804
    Location:179424
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:347424
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  12. XM_011522214.3XP_011520516.1  sodium/nucleoside cotransporter 1 isoform X7

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:179512
    nupC; nucleoside transporter
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:367509
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  13. XM_047433322.1XP_047289278.1  sodium/nucleoside cotransporter 1 isoform X11

  14. XM_011522218.3XP_011520520.1  sodium/nucleoside cotransporter 1 isoform X12

    Conserved Domains (2) summary
    pfam01773
    Location:184253
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07670
    Location:265361
    Gate; Nucleoside recognition
  15. XM_047433320.1XP_047289276.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  16. XM_011522216.2XP_011520518.1  sodium/nucleoside cotransporter 1 isoform X10

    See identical proteins and their annotated locations for XP_011520518.1

    UniProtKB/TrEMBL
    B7Z3L5
    Conserved Domains (4) summary
    TIGR00804
    Location:101512
    nupC; nucleoside transporter
    pfam01773
    Location:106175
    Nucleos_tra2_N; Na+ dependent nucleoside transporter N-terminus
    pfam07662
    Location:289512
    Nucleos_tra2_C; Na+ dependent nucleoside transporter C-terminus
    pfam07670
    Location:187283
    Gate; Nucleoside recognition

RNA

  1. XR_931945.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    82637040..82727893
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379175.1XP_054235150.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  2. XM_054379174.1XP_054235149.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  3. XM_054379185.1XP_054235160.1  sodium/nucleoside cotransporter 1 isoform X8

  4. XM_054379180.1XP_054235155.1  sodium/nucleoside cotransporter 1 isoform X3

    UniProtKB/TrEMBL
    B7Z3L5
  5. XM_054379176.1XP_054235151.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  6. XM_054379177.1XP_054235152.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  7. XM_054379179.1XP_054235154.1  sodium/nucleoside cotransporter 1 isoform X2

    UniProtKB/TrEMBL
    B7Z3L5
  8. XM_054379182.1XP_054235157.1  sodium/nucleoside cotransporter 1 isoform X5

    UniProtKB/TrEMBL
    B7Z3L5
  9. XM_054379183.1XP_054235158.1  sodium/nucleoside cotransporter 1 isoform X6

    UniProtKB/TrEMBL
    B7Z3L5
  10. XM_054379181.1XP_054235156.1  sodium/nucleoside cotransporter 1 isoform X4

    UniProtKB/TrEMBL
    B7Z3L5
  11. XM_054379186.1XP_054235161.1  sodium/nucleoside cotransporter 1 isoform X9

    UniProtKB/TrEMBL
    B7Z3L6
  12. XM_054379184.1XP_054235159.1  sodium/nucleoside cotransporter 1 isoform X7

    UniProtKB/TrEMBL
    B7Z3L5
  13. XM_054379188.1XP_054235163.1  sodium/nucleoside cotransporter 1 isoform X11

  14. XM_054379189.1XP_054235164.1  sodium/nucleoside cotransporter 1 isoform X12

  15. XM_054379178.1XP_054235153.1  sodium/nucleoside cotransporter 1 isoform X1

    UniProtKB/TrEMBL
    B7Z3L5
  16. XM_054379187.1XP_054235162.1  sodium/nucleoside cotransporter 1 isoform X10

    UniProtKB/TrEMBL
    B7Z3L5

RNA

  1. XR_008489030.1 RNA Sequence