UBA3 ubiquitin like modifier activating enzyme 3 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: UBA3provided by VGNC
Official Full Name: ubiquitin like modifier activating enzyme 3provided by VGNC
Primary source: VGNC:VGNC:48038
See related: Ensembl:ENSCAFG00845010556
Gene type: protein coding
RefSeq status: MODEL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: UBE1C
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	20	NC_051824.1 (22683590..22708036)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	20	NC_006602.4 (22632410..22656797)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	20	NC_049241.1 (22790714..22815179)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	20	NC_049280.1 (22377507..22401872)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	20	NC_049761.1 (22720892..22745308)

Chromosome 20 - NC_051824.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables NEDD8 activating enzyme activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein neddylation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: NEDD8-activating enzyme E1 catalytic subunit

Names: ubiquitin-activating enzyme E1C (UBA3 homolog, yeast)

XP_005632330.1

EC 6.2.1.64

EC 6.3.2.-

XP_038283105.1

EC 6.2.1.64

EC 6.3.2.-

XP_038283106.1

EC 6.2.1.64

EC 6.3.2.-

XP_038283107.1

EC 6.2.1.64

EC 6.3.2.-

XP_038358855.1

EC 6.2.1.64

EC 6.3.2.-

XP_038358856.1

EC 6.2.1.64

EC 6.3.2.-

XP_038358857.1

EC 6.2.1.64

EC 6.3.2.-

XP_038421806.1

EC 6.2.1.64

EC 6.3.2.-

XP_038421807.1

EC 6.2.1.64

EC 6.3.2.-

XP_038421808.1

EC 6.2.1.64

EC 6.3.2.-

XP_038485923.1

EC 6.2.1.64

EC 6.3.2.-

XP_038485924.1

EC 6.2.1.64

EC 6.3.2.-

XP_038485925.1

EC 6.2.1.64

EC 6.3.2.-

XP_851790.1

EC 6.2.1.64

EC 6.3.2.-

XP_864203.1

EC 6.2.1.64

EC 6.3.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051824.1 Reference ROS_Cfam_1.0

Range

22683590..22708036

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038427177.1 → XP_038283105.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1

UniProtKB/TrEMBL

A0A8C0KHJ5, A0A8C0S5E2, A0A8C0S709, A0A8I3NAK8, A0A8I3NBH3

Related

ENSCAFP00845014585.1, ENSCAFT00845018681.1

Conserved Domains (2) summary

cd01488
Location:71 → 368

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:376 → 461

E2_bind; E2 binding domain
XM_038427178.1 → XP_038283106.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2

UniProtKB/TrEMBL

A0A8C0KDD1, A0A8C0S5Y5, A0A8C0S709, A0A8I3NBH3, A0A8I3NHJ7

Related

ENSCAFP00845014514.1, ENSCAFT00845018605.1

Conserved Domains (2) summary

cd01488
Location:57 → 354

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:362 → 447

E2_bind; E2 binding domain
XM_038427179.1 → XP_038283107.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3

UniProtKB/TrEMBL

A0A8C0S709, A0A8I3NBH3, A0A8I3NEL0, A0A8P0TKJ1

Related

ENSCAFP00845014693.1, ENSCAFT00845018820.1

Conserved Domains (2) summary

cd01488
Location:50 → 347

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:355 → 440

E2_bind; E2 binding domain

Alternate UMICH_Zoey_3.1

Genomic

NC_049280.1 Alternate UMICH_Zoey_3.1

Range

22377507..22401872

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038502927.1 → XP_038358855.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1

Conserved Domains (2) summary

cd01488
Location:71 → 368

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:376 → 461

E2_bind; E2 binding domain
XM_038502928.1 → XP_038358856.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2

Conserved Domains (2) summary

cd01488
Location:57 → 354

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:362 → 447

E2_bind; E2 binding domain
XM_038502929.1 → XP_038358857.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3

Conserved Domains (2) summary

cd01488
Location:50 → 347

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:355 → 440

E2_bind; E2 binding domain

Alternate UNSW_CanFamBas_1.0

Genomic

NC_049761.1 Alternate UNSW_CanFamBas_1.0

Range

22720892..22745308

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038629995.1 → XP_038485923.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1

Conserved Domains (2) summary

cd01488
Location:71 → 368

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:376 → 461

E2_bind; E2 binding domain
XM_038629996.1 → XP_038485924.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2

Conserved Domains (2) summary

cd01488
Location:57 → 354

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:362 → 447

E2_bind; E2 binding domain
XM_038629997.1 → XP_038485925.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3

Conserved Domains (2) summary

cd01488
Location:50 → 347

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:355 → 440

E2_bind; E2 binding domain

Alternate UU_Cfam_GSD_1.0

Genomic

NC_049241.1 Alternate UU_Cfam_GSD_1.0

Range

22790714..22815179

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038565878.1 → XP_038421806.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1

UniProtKB/TrEMBL

A0A8C0KHJ5, A0A8C0S5E2, A0A8C0S709, A0A8I3NAK8, A0A8I3NBH3

Conserved Domains (2) summary

cd01488
Location:71 → 368

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:376 → 461

E2_bind; E2 binding domain
XM_038565879.1 → XP_038421807.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2

UniProtKB/TrEMBL

A0A8C0KDD1, A0A8C0S5Y5, A0A8C0S709, A0A8I3NBH3, A0A8I3NHJ7

Conserved Domains (2) summary

cd01488
Location:57 → 354

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:362 → 447

E2_bind; E2 binding domain
XM_038565880.1 → XP_038421808.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3

UniProtKB/TrEMBL

A0A8C0S709, A0A8I3NBH3, A0A8I3NEL0, A0A8P0TKJ1

Conserved Domains (2) summary

cd01488
Location:50 → 347

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:355 → 440

E2_bind; E2 binding domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

NC_006602.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

Range

22632410..22656797

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_859110.6 → XP_864203.1 NEDD8-activating enzyme E1 catalytic subunit isoform X1

See identical proteins and their annotated locations for XP_864203.1

UniProtKB/TrEMBL

A0A8C0KHJ5, A0A8C0S5E2, A0A8C0S709, A0A8I3NAK8, A0A8I3NBH3

Conserved Domains (2) summary

cd01488
Location:71 → 368

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:376 → 461

E2_bind; E2 binding domain
XM_846697.6 → XP_851790.1 NEDD8-activating enzyme E1 catalytic subunit isoform X2

See identical proteins and their annotated locations for XP_851790.1

UniProtKB/TrEMBL

A0A8C0KDD1, A0A8C0S5Y5, A0A8C0S709, A0A8I3NBH3, A0A8I3NHJ7

Conserved Domains (2) summary

cd01488
Location:57 → 354

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:362 → 447

E2_bind; E2 binding domain
XM_005632273.4 → XP_005632330.1 NEDD8-activating enzyme E1 catalytic subunit isoform X3

See identical proteins and their annotated locations for XP_005632330.1

UniProtKB/TrEMBL

A0A8C0S709, A0A8I3NBH3, A0A8I3NEL0, A0A8P0TKJ1

Conserved Domains (2) summary

cd01488
Location:50 → 347

Uba3_RUB; Ubiquitin activating enzyme (E1) subunit UBA3. UBA3 is part of the heterodimeric activating enzyme (E1), specific for the Rub family of ubiquitin-like proteins (Ubls). E1 enzymes are part of a conjugation cascade to attach Ub or Ubls, covalently to ...

pfam08825
Location:355 → 440

E2_bind; E2 binding domain